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Research at St Andrews

Journal of Medicinal Chemistry, 0022-2623

Journal

  1. 2018
  2. Published

    Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation

    McAllister, L., Butler, C., Mente, S., O'Neil, S. V., Fonseca, K., Piro, J., Cianfrogna, J., Foley, T., Gilbert, A., Harris, A., Helal, C. J., Johnson, D. S., Montgomery, J. I., Nason, D. M., Noell, S., Pandit, J., Rogers, B. N., Samad, T. A., Shaffer, C. L., da Silva, R. G. & 3 others, Uccello, D. P., Webb, D. & Brodney, M. A., 12 Apr 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 3008–3026

    Research output: Contribution to journalArticle

  3. 2017
  4. E-pub ahead of print

    Emergence of small molecule non-RGD-mimetic inhibitors for RGD integrins

    Miller, L. M., Pritchard, J. M., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 30 Jan 2017, In : Journal of Medicinal Chemistry. 60, 8, p. 3241-3251

    Research output: Contribution to journalArticle

  5. Published

    Rational design of autotaxin inhibitors by structural evolution of endogenous modulators

    Keune, W-J., Potjewyd, F., Heidebrecht, T., Salgado-Polo, F., Macdonald, S. J. F., Chelvarajan, L., Abdel Latif, A., Soman, S., Morris, A. J., Watson, A. J. B., Jamieson, C. & Perrakis, A., 9 Mar 2017, In : Journal of Medicinal Chemistry. 60, 5, p. 2006-2017 12 p.

    Research output: Contribution to journalArticle

  6. Published

    Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode

    Miller, L. M., Keune, W-J., Castagna, D., Young, L. C., Duffy, E. L., Potjewyd, F., Salgado-Polo, F., Garcia, P. E., Semaan, D., Pritchard, J. M., Perrakis, A., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 722-748 27 p.

    Research output: Contribution to journalArticle

  7. 2014
  8. Published

    Establishment of a structure-activity relationship of the 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness

    Seixas, J. D., Luengo-Arratta, S. A., Diaz, R., Saldivia, M., Rojas-Barros, D. I., Manzano, P., Gonzalez, S., Berlanga, M., Smith, T. K., Navarro, M. & Pollastri, M. P., 12 Jun 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4834-4848 15 p.

    Research output: Contribution to journalArticle

  9. Published

    N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

    Bautista-Aguilera, O. M., Samadi, A., Chioua, M., Nikolic, K., Filipic, S., Agbaba, D., Soriano, E., De Andrés, L., Rodríguez-Franco, M. I., Alcaro, S., Ramsay, R. R., Ortuso, F., Yañez, M. & Marco-Contelles, J., 26 Dec 2014, In : Journal of Medicinal Chemistry. 57, 24, p. 10455-10463 9 p.

    Research output: Contribution to journalArticle

  10. 2013
  11. Published

    A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro

    Zhou, L., Stewart, G., Rideau, E., Westwood, N. J. & Smith, T. K., 14 Feb 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 796–806 11 p.

    Research output: Contribution to journalArticle

  12. Published

    Development and characterization of glutamyl-protected N-hydroxyguanidines as reno-active nitric oxide donor drugs with therapeutic potential in acute renal failure

    Zhang, Q., Milliken, P., Kulczynska, A., Slawin, A. M. Z., Gordon, A., Kirkby, N. S., Webb, D. J., Botting, N. P. & Megson, I. L., 11 Jul 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5321-5334 14 p.

    Research output: Contribution to journalArticle

  13. 2012
  14. Published

    Allosteric inhibition of cobalt binding to albumin by fatty acids: Implications for the detection of myocardial ischemia

    Lu, J., Stewart, A. J., Sadler, P. J., Pinheiro, T. J. T. & Blindauer, C. A., 10 May 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4425-4430 6 p.

    Research output: Contribution to journalArticle

  15. Published

    Exploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase

    Bhatt, B., Boehm, R., Kerry, P. S., Dyason, J. C., Russell, R. J. M., Thomson, R. J. & von Itzstein, M., 25 Oct 2012, In : Journal of Medicinal Chemistry. 55, 20, p. 8963-8968 6 p.

    Research output: Contribution to journalArticle

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