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Research at St Andrews

Alan J. Stewart

Person

  1. Forthcoming

    The X files: ''The mystery of X chromosome instability in Alzheimer's disease''

    Bajic, V. P., Essak, M., Zivkovic, L., Stewart, A. J., Zafirovic, S., Bajic, V., Gojobori, T., Isenovic, E. & Spremo-Potparevic, B., 13 Dec 2019, (Accepted/In press) In : Frontiers in Genetics.

    Research output: Contribution to journalReview article

  2. Forthcoming

    Coagulatory defects in type-1 and type-2 diabetes

    Sobczak, A. I. S. & Stewart, A. J., 12 Dec 2019, (Accepted/In press) In : International Journal of Molecular Sciences.

    Research output: Contribution to journalReview article

  3. Forthcoming

    Reduced plasma magnesium levels in type-1 diabetes associate with prothrombotic changes in fibrin clotting and fibrinolysis

    Sobczak, A. I. S., Phoenix, F. A., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., 11 Nov 2019, (Accepted/In press) In : Thrombosis and Haemostasis.

    Research output: Contribution to journalArticle

  4. Published

    A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

    Coverdale, J. P. C., Barnett, J. P., Adamu, A. H., Griffiths, E. J., Stewart, A. J. & Blindauer, C. A., 1 Nov 2019, In : Metallomics. 11, 11, p. 1805-1819 15 p.

    Research output: Contribution to journalArticle

  5. Published

    Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

    Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 28 Aug 2019, In : biorxiv. 38 p.

    Research output: Contribution to journalArticle

  6. Published

    Changes in plasma free fatty acids associated with type-2 diabetes

    Sobczak, A. I. S., Blindauer, C. A. & Stewart, A. J., 28 Aug 2019, In : Nutrients. 11, 9, 42 p., 2022.

    Research output: Contribution to journalReview article

  7. Published

    Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature

    Wort, J. L., Ackermann, K., Giannoulis, A., Stewart, A. J., Norman, D. G. & Bode, B. E., 19 Aug 2019, In : Angewandte Chemie - International Edition. 58, 34, p. 11681-11685 5 p.

    Research output: Contribution to journalArticle

  8. Published

    Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature

    Wort, J., Ackermann, K., Giannoulis, A., Stewart, A. J., Norman, D. & Bode, B. E., 19 Aug 2019, In : Angewandte Chemie. 131, 34, p. 11807-11811 6 p.

    Research output: Contribution to journalArticle

  9. Published
  10. Published

    Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes

    Sobczak, A. I. S., Stefanowicz, F., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., Feb 2019, In : BioMetals. 32, 1, p. 123-138 16 p.

    Research output: Contribution to journalArticle

  11. Published

    On the origin of proteins in human drusen: the meet, greet and stick hypothesis

    Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J. & Lengyel, I., May 2019, In : Progress in Retinal and Eye Research. 70, p. 55-84 30 p.

    Research output: Contribution to journalArticle

  12. Published

    Crosstalk between zinc and fatty acids in plasma

    Coverdale, J. P. C., Khazaipoul, S., Arya, S., Stewart, A. J. & Blindauer, C. A., Apr 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 4, p. 532-542 11 p.

    Research output: Contribution to journalReview article

  13. Published

    Influence of zinc on glycosaminoglycan neutralisation during coagulation

    Sobczak, A. I. S., Pitt, S. J. & Stewart, A. J., Sep 2018, In : Metallomics. 10, 9, p. 1180-1190 11 p.

    Research output: Contribution to journalReview article

  14. Published

    Ischemia-modified albumin: crosstalk between fatty acid and cobalt binding

    Coverdale, J. P. C., Katundu, K. G. H., Sobczak, A. I. S., Arya, S., Blindauer, C. A. & Stewart, A. J., Aug 2018, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 135, p. 147-157 11 p.

    Research output: Contribution to journalReview article

  15. Published

    Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein

    Martin, E. M., Kondrat, F. D. L., Stewart, A. J., Scrivens, J. H., Sadler, P. J. & Blindauer, C. A., 5 Jun 2018, In : Scientific Reports. 8, 13 p., 8646.

    Research output: Contribution to journalArticle

  16. Published

    Glycosaminoglycan neutralization in coagulation control

    Sobczak, A. I. S., Pitt, S. J. & Stewart, A. J., Jun 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 6, p. 1258-1270 14 p.

    Research output: Contribution to journalReview article

  17. Published

    Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration

    Arya, S., Emri, E., Synowsky, S. A., Shirran, S. L., Barzegar-Befroei, N., Peto, T., Botting, C. H., Lengyel, I. & Stewart, A. J., Jul 2018, In : Experimental Eye Research. 172, p. 21-29 9 p.

    Research output: Contribution to journalArticle

  18. Published

    Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase

    Wen, H., Tang, B., Stewart, A. J., Tao, Y., Shao, Y., Cui, Y., Yue, H., Pei, J., Liu, Z., Mei, L., Yu, R. & Jiang, L., 14 Feb 2018, In : Journal of Agricultural and Food Chemistry. 66, 6, p. 1401-1407 7 p.

    Research output: Contribution to journalArticle

  19. Published

    PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization

    Stewart, A. J., Leong, D. T. K. & Farquharson, C., Jan 2018, In : FASEB Journal. 32, 1, p. 20-25 6 p.

    Research output: Contribution to journalArticle

  20. Published

    Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage

    Reilly-O'Donnell, B., Robertson, G. B., Karumbi, A., McIntyre, C., Bal, W., Nishi, M., Takeshima, H., Stewart, A. J. & Pitt, S. J., 11 Aug 2017, In : Journal of Biological Chemistry. 292, 32, p. 13361-13373 13 p.

    Research output: Contribution to journalArticle

  21. Published

    Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high fat diet

    Jovanovic, A., Obradovic, M., Sudar-Milovanovic, E., Stewart, A. J., Pitt, S. J., Alvantic, D., Aleksic, E. & Isenovic, E. R., Dec 2017, In : Molecular and Cellular Biochemistry. 436, 1-2, p. 49-58 10 p.

    Research output: Contribution to journalArticle

  22. Published

    17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats

    Zafirovic, S., Obradovic, M., Sudar-Milovanovic, E., Jovanovic, A., Stanimirovic, J., Stewart, A. J., Pitt, S. J. & Isenovic, E. R., 5 May 2017, In : Molecular and Cellular Endocrinology. 446, p. 12-20 9 p.

    Research output: Contribution to journalArticle

  23. Published

    Influence of a high-fat diet on cardiac iNOS in female rats

    Jovanovic, A., Sudar-Milovanovic, E., Obradovic, M., Pitt, S. J., Stewart, A. J., Zafirovic, S., Stanimirovic, J., Radak, D. & Isenovic, E. R., 2017, In : Current Vascular Pharmacology. 15, 5, p. 491-500 10 p.

    Research output: Contribution to journalArticle

  24. Published

    Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins

    Handing, K. B., Shabalin, I. G., Kassaar, O., Khazaipoul, S., Blindauer, C. A., Stewart, A. J., Chruszcz, M. & Minor, W., 1 Nov 2016, In : Chemical Science. 7, 11, p. 6635-6648 14 p.

    Research output: Contribution to journalArticle

  25. Published

    Response to Qian and Colvin: zinc-mediated regulation of the cardiac ryanodine receptor occurs via multiple binding sites

    Woodier, J., Rainbow, R. D., Stewart, A. J. & Pitt, S. J., 19 Feb 2016, In : Journal of Biological Chemistry. 291, 8, p. 4267

    Research output: Contribution to journalLetter

  26. Published

    A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats

    Stanimirovic, J., Obradovic, M., Jovanovic, A., Sudar-Milovanovic, E., Zafirovic, S., Pitt, S. J., Stewart, A. J. & Isenovic, E. R., 1 Apr 2016, In : Nitric Oxide. 54, p. 51-59 9 p.

    Research output: Contribution to journalArticle

  27. Published

    Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth

    Arastoo, M., Hacker, C., Popovics, P., Lucocq, J. M. & Stewart, A. J., Feb 2016, In : Histochemistry and Cell Biology. 145, 2, p. 163-173

    Research output: Contribution to journalArticle

  28. Published

    Zinc controls RyR2 activity during excitation-contraction coupling

    Stewart, A. J. & Pitt, S. J., Sep 2015, In : Channels. 9, 5, p. 223-225

    Research output: Contribution to journalArticle

  29. Published

    Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin: implications for cardiovascular disease

    Blindauer, C. A., Khazaipoul, S., Yu, R. & Stewart, A. J., 2016, In : Current Topics in Medicinal Chemistry. 16, 27, p. 3021-3032 12 p.

    Research output: Contribution to journalArticle

  30. Published

    Intracellular zinc modulates cardiac ryanodine receptor-mediated calcium release

    Woodier, J., Rainbow, R. D., Stewart, A. J. & Pitt, S. J., 10 Jul 2015, In : Journal of Biological Chemistry. 290, 28, p. 17599-17610 12 p.

    Research output: Contribution to journalArticle

  31. Published

    The reduced Co2+-binding ability of ischaemia-modified albumin is unlikely to be because of oxidative modification of the N-terminus

    Stewart, A. J. & Blindauer, C. A., Dec 2015, In : Liver International. 35, 12, p. 2622-2623 2 p.

    Research output: Contribution to journalLetter

  32. Published

    Examining a new role for zinc in regulating calcium release in cardiac muscle

    Pitt, S. J. & Stewart, A. J., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 359-363

    Research output: Contribution to journalArticle

  33. Published
  34. Published

    In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart

    Obradovic, M., Stewart, A. J., Pitt, S. J., Labudovic-Borovic, M., Sudar, E., Petrovic, V., Zafirovic, S., Maravic-Stojkovic, V., Vasic, V. & Isenovic, E. R., 5 May 2014, In : Molecular and Cellular Endocrinology. 388, 1-2, p. 58-68

    Research output: Contribution to journalArticle

  35. Published

    Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation

    Kassaar, O., McMahon, S. A., Thompson, R., Botting, C. H., Naismith, J. H. & Stewart, A. J., 20 Mar 2014, In : Blood. 123, 12, p. 1948-1955 8 p.

    Research output: Contribution to journalArticle

  36. Published

    A canonical EF-loop directs Ca2+-sensitivity in phospholipase C-η2

    Popovics, P., Lu, J., Kamil, L. N., Morgan, K., Millar, R. P., Schmid, R., Blindauer, C. A. & Stewart, A. J., 1 Mar 2014, In : Journal of Cellular Biochemistry. 115, 3, p. 557–565 9 p.

    Research output: Contribution to journalArticle

  37. Published

    Effects of obesity and estradiol on Na+/K+-ATPase and their relevance to cardiovascular disease

    Obradovic, M., Bjelogrlic, P., Rizzo, M., Katsiki, N., Haidara, M., Stewart, A. J., Jovanovic, A. & Isenovic, E. R., 1 Sep 2013, In : Journal of Endocrinology. 218, p. R13-R23 11 p.

    Research output: Contribution to journalArticle

  38. Published

    Allosteric modulation of zinc speciation by fatty acids

    Barnett, J. P., Blindauer, C. A., Kassaar, O., Khazaipoul, S., Martin, E. M., Sadler, P. J. & Stewart, A. J., Dec 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 12, p. 5456-5464 9 p.

    Research output: Contribution to journalArticle

  39. Published

    Albumin research in the 21st century

    Peters Jr, T. & Stewart, A. J., Dec 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 12, p. 5351-5353 3 p.

    Research output: Contribution to journalEditorial

  40. Published

    Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth

    Popovics, P., Gray, A., Arastoo, M., Finelli, D. K., Tan, A. J. L. & Stewart, A. J., Mar 2013, In : Journal of Neurochemistry. 124, 5, p. 632-644 13 p.

    Research output: Contribution to journalArticle

  41. Published

    The formation and Zn2+-dependence of histidine-rich glycoprotein-containing immune complexes.

    Kassaar, O., Powis, S. J. & Stewart, A. J., Dec 2012, Advances in Medicine and Biology. Berhardt, L. V. (ed.). Nova Science Publishers, Vol. 58. p. 153-166 14 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  42. Published

    Structural and immunologic characterization of bovine, horse, and rabbit serum albumins

    Majorek, K. A., Porebski, P. J., Dayal, A., Zimmerman, M. D., Jablonska, K., Stewart, A. J., Chruszcz, M. & Minor, W., 1 Oct 2012, In : Molecular Immunology. 52, 3-4, p. 174-182 9 p.

    Research output: Contribution to journalArticle

  43. Published

    Allosteric inhibition of cobalt binding to albumin by fatty acids: Implications for the detection of myocardial ischemia

    Lu, J., Stewart, A. J., Sadler, P. J., Pinheiro, T. J. T. & Blindauer, C. A., 10 May 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4425-4430 6 p.

    Research output: Contribution to journalArticle

  44. Published

    Phospholipase C-η activity may contribute to Alzheimer’s disease-associated calciumopathy.

    Popovics, P. & Stewart, A. J., Jun 2012, In : Journal of Alzheimer's Disease. 30, p. 737-744 8 p.

    Research output: Contribution to journalArticle

  45. Published

    A molecular mechanism for modulating plasma Zn speciation by fatty acids

    Lu, J., Stewart, A. J., Sleep, D., Sadler, P. J., Pinheiro, T. J. T. & Blindauer, C. A., 25 Jan 2012, In : Journal of the American Chemical Society. 134, 3, p. 1454-1457 4 p.

    Research output: Contribution to journalArticle

  46. Published

    Putative roles for phospholipase C-η enzymes in neuronal Ca2+ signal modulation.

    Popovics, P. & Stewart, A. J., 1 Feb 2012, In : Biochemical Society Transactions. 40, p. 282-286 5 p.

    Research output: Contribution to journalArticle

  47. Published

    Phospholipase C-η2 is activated by elevated intracellular Ca2+ levels.

    Popovics, P., Beswick, W., Guild, S., Cramb, G., Morgan, K., Millar, R. P. & Stewart, A. J., 1 Nov 2011, In : Cellular Signalling. 23, 11, p. 1777-1784 8 p.

    Research output: Contribution to journalArticle

  48. Published

    Regulation of pituitary inhibin/activin subunits and follistatin gene expression by gonadotropin-releasing hormone in female rats.

    Popovics, P., Rekasi, Z., Stewart, A. J. & Kovacs, M., 1 Jul 2011, In : Journal of Endocrinology. 210, p. 71-79 9 p.

    Research output: Contribution to journalArticle

  49. Published
  50. Published

    Design of mutated forms of human serum albumin with altered metal binding characteristics for pharmacological or cell culture uses.

    Berezenko, S., Sadler, P. J., Stewart, A. J., Blindauer, C. A. & Bunyan, K. E., 5 Feb 2004, IPC No. C07K 14/765 (2006.01), Patent No. WO/2004/011499

    Research output: Patent

  51. Published

    A role for inositol monophosphatase 1 (IMPA1) in salinity adaptation in the euryhaline eel (Anguilla anguilla)

    Kalujnaia, S., McVee, J., Kasciukovic, T., Stewart, A. J. & Cramb, G., Oct 2010, In : FASEB Journal. 24, p. 3981-3991 11 p.

    Research output: Contribution to journalArticle

  52. Published

    Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: Implications for luteolysis

    Dickinson, R. E., Stewart, A. J., Myers, M., Millar, R. P. & Duncan, W. C., Jun 2009, In : Endocrinology. 150, 6, p. 2873-2881 9 p.

    Research output: Contribution to journalArticle

  53. Published

    Role of Tyr84 in controlling the reactivity of Cys34 of human albumin

    Stewart, A. J., Blindauer, C., Berezenko, S., Sleep, D., Tooth, D. & Sadler, P. J., 21 Dec 2004, In : FEBS Journal. 272, 2, p. 353-362 10 p.

    Research output: Contribution to journalArticle

  54. Published

    Plasma fatty acid levels may regulate the Zn2+-dependent activities of histidine-rich glycoprotein.

    Stewart, A. J., Blindauer, CA. & Sadler, PJ., 2009, In : Biochimie. 91, p. 1518-1522 5 p.

    Research output: Contribution to journalArticle

  55. Published

    Structure, properties, and engineering of the major zinc binding site on human albumin

    Blindauer, CA., Harvey, I., Bunyan, KE., Stewart, A. J., Sleep, D., Harrison, D. J., Berezenko, S. & Sadler, PJ., 21 Aug 2009, In : Journal of Biological Chemistry. 284, p. 23116-23124 9 p.

    Research output: Contribution to journalArticle

  56. Published

    Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals.

    Stewart, A. J., Katz, AA., Millar, RP. & Morgan, K., Nov 2009, In : Neuroendocrinology. 90, 4, p. 416-432 17 p.

    Research output: Contribution to journalArticle

  57. Published

    Albumin as a zinc carrier: properties of its high-affinity zinc-binding site

    Lu, J., Stewart, A. J., Sadler, PJ., Pinheiro, TJT. & Blindauer, CA., Dec 2008, In : Biochemical Society Transactions. 36, 6, p. 1317-1321 5 p.

    Research output: Contribution to journalArticle

  58. Published

    Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo

    Morgan, K., Stewart, A. J., Miller, NA., Mullen, P., Muir, M., Dodds, M., Medda, F., Harrison, D. J., Langdon, S. & Millar, RP., 1 Aug 2008, In : Cancer Research. 68, 15, p. 6331-6340 10 p.

    Research output: Contribution to journalArticle

  59. Published

    Antiproliferative effects of GnRH agonists: prospects and problems for cancer therapy

    White, CD., Stewart, A. J., Lu, ZL., Millar, RP. & Morgan, K., Aug 2008, In : Neuroendocrinology. 88, 2, p. 67-79 13 p.

    Research output: Contribution to journalArticle

  60. Published

    Identification of a novel ligand binding residue Arg38(1.35) in the human gonadotropin-releasing hormone receptor

    Stewart, A. J., Sellar, R., Wilson, D. J., Millar, R. P. & Lu, Z-L., Jan 2008, In : Molecular Pharmacology. 73, 1, p. 75-81 7 p.

    Research output: Contribution to journalArticle

  61. Published

    Phospholipase C-η enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues

    Stewart, A. J., Morgan, K., Farquharson, C. & Millar, RP., Nov 2007, In : Neuroendocrinology. 86, 4, p. 243-248 6 p.

    Research output: Contribution to journalArticle

  62. Published

    The presence of PHOSPHO1 in matrix vesicles and its developmental expression prior to skeletal mineralization

    Stewart, A. J., Roberts, SJ., Seawright, E., Davey, MG., Fleming, RH. & Farquharson, C., Nov 2006, In : Bone. 39, 5, p. 1000-1007 8 p.

    Research output: Contribution to journalArticle

  63. Published

    Elevated expression of hypoxia inducible factor-2α in terminally differentiating growth plate chondrocytes

    Stewart, A. J., Houston, B. & Farquharson, C., Feb 2006, In : Journal of Cellular Physiology. 206, 2, p. 435-440 6 p.

    Research output: Contribution to journalArticle

  64. Published

    Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2

    Roberts, SJ., Stewart, A. J., Schmid, R., Blindauer, CA., Bond, SR., Sadler, PJ. & Farquharson, C., 31 Aug 2005, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1752, 1, p. 73-82 10 p.

    Research output: Contribution to journalArticle

  65. Published

    Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.

    Stewart, A. J., Mukherjee, J., Roberts, SJ., Lester, D. & Farquharson, C., Jan 2005, In : International Journal of Molecular Medicine. 15, p. 117-121

    Research output: Contribution to journalArticle

  66. Published

    Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities

    Roberts, SJ., Stewart, A. J., Sadler, PJ. & Farquharson, C., 15 Aug 2004, In : Biochemical Journal. 382, 1, p. 59-65 7 p.

    Research output: Contribution to journalArticle

  67. Published

    PHOSPHO1 - A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage

    Houston, B., Stewart, A. J. & Farquharson, C., Apr 2004, In : Bone. 34, 4, p. 629-637 9 p.

    Research output: Contribution to journalArticle

  68. Published

    Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily

    Stewart, A. J., Schmid, R., Blindauer, CA., Paisey, SJ. & Farquharson, C., Dec 2003, In : Protein Engineering. 16, 12, p. 889-895 7 p.

    Research output: Contribution to journalArticle

  69. Published

    Interdomain zinc site on human albumin

    Stewart, A. J., Blindauer, CA., Berezenko, S., Sleep, D. & Sadler, PJ., 1 Apr 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 7, p. 3701-3706 6 p.

    Research output: Contribution to journalArticle

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