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Research at St Andrews

Glen Alfred Cottrell

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Glen Alfred Cottrell
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United Kingdom

Email: gac@st-andrews.ac.uk

Direct phone: +44 (0)1334 46

Research overview

Novel ligand-gated ion channels in nerve cells.


Nerve cells communicate by releasing chemical messengers, often referred to as neurotransmitters. Some neurotransmitters exert fast effects (via ligand-gated ion channels) others slow effects (via enzyme coupled receptors). We have recently discovered fast actions of two transmitters hithertoo only thought to produce slow effects: a neuropeptide, FMRFamide, and dopamine. The channels directly gated by these substances are being studied in detail. The peptide gated channel (now cloned) is unique in showing a high selectivity for Na ions and also in being antagonised by another endogenous, related, peptide.

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