Systems Pathology and Cancer
Cancer is a remarkably heterogenous disease and the increasing complexity of molecular changes during tumour evolution highlights the importance of identifying events that drive this process. The Reynolds lab is interested in identifying those molecular changes which drive tumour formation with particular emphasis on 1) novel proteins in the Hippo signaling pathway and 2) resistance mechanisms to therapeutic drugs in cancer. We are employing biochemistry, molecular biology and cell biology approaches to investigate the nature and context of these factors and how they impact upon carcinogenesis. An understanding of their biology may also contribute to the development of better strategies to identify aggressive tumours early, before the development of metastasis. Another interest is exploring models of physiological tissue settings and disease pathologies where the Hippo pathway plays a role.
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