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Research at St Andrews

Rafael Guimaraes da Silva

Person

  1. Published

    An exceptionally potent inhibitor of human CD73

    Bowman, C. E., da Silva, R. G., Pham, A. & Young, S. W., 6 Aug 2019, In : Biochemistry. 58, 31, p. 3331-3334 4 p.

    Research output: Contribution to journalArticle

  2. Published

    Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine

    Thomson, C. M., Alphey, M. S., Fisher, G. & da Silva, R. G., 16 Jul 2019, In : Biochemistry. 58, 28, p. 3078-3086

    Research output: Contribution to journalArticle

  3. Published

    Linear Eyring plots conceal a change in rate-limiting step in an enzyme reaction

    Machado, T. F. G., Gloster, T. & da Silva, R. G., 11 Dec 2018, In : Biochemistry. 57, 49, p. 6757-6761

    Research output: Contribution to journalArticle

  4. Published

    Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase

    Fisher, G., Thomson, C. M., Stroek, R., Czekster, C. M., Hirschi, J. S. & da Silva, R. G., 24 Jul 2018, In : Biochemistry. 57, 29, p. 4357-4367

    Research output: Contribution to journalArticle

  5. Published

    Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase

    Alphey, M. S., Fisher, G., Ge, Y., Gould, E. R., Guerreiro Machado, T. F., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 11 May 2018, In : ACS Catalysis. 8, 6, p. 5601-5610 10 p.

    Research output: Contribution to journalArticle

  6. Published

    Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation

    McAllister, L., Butler, C., Mente, S., O'Neil, S. V., Fonseca, K., Piro, J., Cianfrogna, J., Foley, T., Gilbert, A., Harris, A., Helal, C. J., Johnson, D. S., Montgomery, J. I., Nason, D. M., Noell, S., Pandit, J., Rogers, B. N., Samad, T. A., Shaffer, C. L., da Silva, R. G. & 3 others, Uccello, D. P., Webb, D. & Brodney, M. A., 12 Apr 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 3008–3026

    Research output: Contribution to journalArticle

  7. Published

    Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase

    Stroek, R., Ge, Y., Talbot, P. D., Glok, M. K., Bernas, K. E., Thomson, C. M., Gould, E. R., Alphey, M. S., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 7 Feb 2017, In : Biochemistry. 56, 5, p. 793-803 11 p.

    Research output: Contribution to journalArticle

  8. Published

    Structural basis for inhibition of human PNP by immucillin-H

    de Azevedo, WF., Canduri, F., dos Santos, DM., Pereira, JH., Dias, MVB., Silva, R. G., Mendes, MA., Basso, LA., Palma, MS. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 309, p. 917–922

    Research output: Contribution to journalArticle

  9. Published

    Crystal structure of human PNP complexed with guanine

    de Azevedo, WF., Canduri, F., dos Santos, D., Pereira, J., Dias, MVB., Silva, R. G., Mendes, MA., Basso, LA., Palma, MS. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 312, p. 767-772

    Research output: Contribution to journalArticle

  10. Published

    Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase

    de Azevedo, WF., dos Santos, G., dos Santos, DM., Olivieri, JR., Canduri, F., Silva, R. G., Basso, LA., Renard, G., Fonseca, IO., Mendes, MA., Palma, MS. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 309, p. 923-928

    Research output: Contribution to journalArticle

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