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Research at St Andrews

Rafael Guimaraes da Silva

Person

  1. 2019
  2. Published

    An exceptionally potent inhibitor of human CD73

    Bowman, C. E., da Silva, R. G., Pham, A. & Young, S. W., 6 Aug 2019, In : Biochemistry. 58, 31, p. 3331-3334 4 p.

    Research output: Contribution to journalArticle

  3. Published

    Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine

    Thomson, C. M., Alphey, M. S., Fisher, G. & da Silva, R. G., 16 Jul 2019, In : Biochemistry. 58, 28, p. 3078-3086

    Research output: Contribution to journalArticle

  4. 2018
  5. Published

    Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase

    Fisher, G., Thomson, C. M., Stroek, R., Czekster, C. M., Hirschi, J. S. & da Silva, R. G., 24 Jul 2018, In : Biochemistry. 57, 29, p. 4357-4367

    Research output: Contribution to journalArticle

  6. Published

    Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase

    Alphey, M. S., Fisher, G., Ge, Y., Gould, E. R., Guerreiro Machado, T. F., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 11 May 2018, In : ACS Catalysis. 8, 6, p. 5601-5610 10 p.

    Research output: Contribution to journalArticle

  7. Published

    Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation

    McAllister, L., Butler, C., Mente, S., O'Neil, S. V., Fonseca, K., Piro, J., Cianfrogna, J., Foley, T., Gilbert, A., Harris, A., Helal, C. J., Johnson, D. S., Montgomery, J. I., Nason, D. M., Noell, S., Pandit, J., Rogers, B. N., Samad, T. A., Shaffer, C. L., da Silva, R. G. & 3 others, Uccello, D. P., Webb, D. & Brodney, M. A., 12 Apr 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 3008–3026

    Research output: Contribution to journalArticle

  8. Published

    Linear Eyring plots conceal a change in rate-limiting step in an enzyme reaction

    Machado, T. F. G., Gloster, T. & da Silva, R. G., 11 Dec 2018, In : Biochemistry. 57, 49, p. 6757-6761

    Research output: Contribution to journalArticle

  9. 2017
  10. Published

    Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase

    Stroek, R., Ge, Y., Talbot, P. D., Glok, M. K., Bernas, K. E., Thomson, C. M., Gould, E. R., Alphey, M. S., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 7 Feb 2017, In : Biochemistry. 56, 5, p. 793-803 11 p.

    Research output: Contribution to journalArticle

  11. 2014
  12. Published

    A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity

    Silva, R. G., Geoghegan, K. F., Qiu, X. & Aulabaugh, A., 2014, In : Analytical Biochemistry. 450, 1, p. 63-69

    Research output: Contribution to journalArticle

  13. 2013
  14. Published

    Selective mitochondrial staining with small fluorescent probes: importance, design, synthesis, challenges and trends for new markers

    Neto, B. AD., Correa, J. R. & Silva, R. G., 2013, In : RSC Advances. 3, p. 5291-5301

    Research output: Contribution to journalArticle

  15. Published

    The Biginelli reaction with an imidazolium-tagged recyclable iron catalyst: kinetics, mechanism, and antitumoral activity

    Ramos, L. M., Guido, B. C., Nobrega, C. C., Correa, J. R., Silva, R. G., de Oliveira, H. CB., Gomes, A. F., Gozzo, F. C. & Neto, B. AD., 2013, In : Chemistry - A European Journal. 19, p. 4156-4168

    Research output: Contribution to journalArticle

  16. 2012
  17. Published

    Constrained bonding environment in the Michaelis complex of Trypanosoma cruzi uridine phosphorylase

    Silva, R. G., Kipp, D. R. & Schramm, V. L., 2012, In : Biochemistry. 51, p. 6715-6717

    Research output: Contribution to journalArticle

  18. Published

    Synthesis, properties and highly selective mitochondria staining with novel, stable and superior benzothiadiazole fluorescent probes

    Neto, B. AD., Carvalho, P. HPR., Santos, D. CBD., Gatto, C. C., Ramos, L. M., de Vasconcelos, N. M., Correa, J. R., Costa, M. B., de Oliveira, H. CB. & Silva, R. G., 2012, In : RSC Advances. 2, p. 1524-1532

    Research output: Contribution to journalArticle

  19. 2011
  20. Published

    Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase

    Silva, R. G., Hirschi, J. S., Ghanem, M., Murkin, A. S. & Schramm, V. L., 2011, In : Biochemistry. 50, p. 2701-2709

    Research output: Contribution to journalArticle

  21. Published
  22. Published

    Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease

    Kipp, D. R., Silva, R. G. & Schramm, V. L., 2011, In : Journal of the American Chemical Society. 133, p. 19358-19361

    Research output: Contribution to journalArticle

  23. Published

    Transition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine

    Silva, R. G., Vetticatt, M. J., Merino, E. F., Cassera, M. B. & Schramm, V. L., 2011, In : Journal of the American Chemical Society. 133, p. 9923-9931

    Research output: Contribution to journalArticle

  24. Published

    Uridine phosphorylase from Trypanosoma cruzi: kinetic and chemical mechanisms

    Silva, R. G. & Schramm, V. L., 2011, In : Biochemistry. 50, p. 9158-9166

    Research output: Contribution to journalArticle

  25. 2010
  26. Published

    Purine nucleoside phosphorylase activity and expression are upregulated in sites affected by periodontal disease

    Batista Jr, E. L., Deves, C., Ayub, L., da Silva, R. G., Filho, LCC., Basso, L. A. & Santos, D. S., 2010, In : Journal of Periodontal Research. 45, p. 664–671

    Research output: Contribution to journalArticle

  27. 2008
  28. Published
  29. 2007
  30. Published

    Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis

    Fonseca, I. O., Silva, R. G., Fernandes, C., de Souza, O. N., Basso, L. A. & Santos, D. S., 2007, In : Archives of Biochemistry and Biophysics. 457, p. 123-133

    Research output: Contribution to journalArticle

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