Skip to content

Research at St Andrews

Rafael Guimaraes da Silva

Person

  1. 2019
  2. Published

    An exceptionally potent inhibitor of human CD73

    Bowman, C. E., da Silva, R. G., Pham, A. & Young, S. W., 6 Aug 2019, In : Biochemistry. 58, 31, p. 3331-3334 4 p.

    Research output: Contribution to journalArticle

  3. Published

    Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine

    Thomson, C. M., Alphey, M. S., Fisher, G. & da Silva, R. G., 16 Jul 2019, In : Biochemistry. 58, 28, p. 3078-3086

    Research output: Contribution to journalArticle

  4. 2018
  5. Published

    Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase

    Fisher, G., Thomson, C. M., Stroek, R., Czekster, C. M., Hirschi, J. S. & da Silva, R. G., 24 Jul 2018, In : Biochemistry. 57, 29, p. 4357-4367

    Research output: Contribution to journalArticle

  6. Published

    Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase

    Alphey, M. S., Fisher, G., Ge, Y., Gould, E. R., Guerreiro Machado, T. F., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 11 May 2018, In : ACS Catalysis. 8, 6, p. 5601-5610 10 p.

    Research output: Contribution to journalArticle

  7. Published

    Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation

    McAllister, L., Butler, C., Mente, S., O'Neil, S. V., Fonseca, K., Piro, J., Cianfrogna, J., Foley, T., Gilbert, A., Harris, A., Helal, C. J., Johnson, D. S., Montgomery, J. I., Nason, D. M., Noell, S., Pandit, J., Rogers, B. N., Samad, T. A., Shaffer, C. L., da Silva, R. G. & 3 others, Uccello, D. P., Webb, D. & Brodney, M. A., 12 Apr 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 3008–3026

    Research output: Contribution to journalArticle

  8. Published

    Linear Eyring plots conceal a change in rate-limiting step in an enzyme reaction

    Machado, T. F. G., Gloster, T. & da Silva, R. G., 11 Dec 2018, In : Biochemistry. 57, 49, p. 6757-6761

    Research output: Contribution to journalArticle

  9. 2017
  10. Published

    Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase

    Stroek, R., Ge, Y., Talbot, P. D., Glok, M. K., Bernas, K. E., Thomson, C. M., Gould, E. R., Alphey, M. S., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 7 Feb 2017, In : Biochemistry. 56, 5, p. 793-803 11 p.

    Research output: Contribution to journalArticle

  11. 2014
  12. Published

    A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity

    Silva, R. G., Geoghegan, K. F., Qiu, X. & Aulabaugh, A., 2014, In : Analytical Biochemistry. 450, 1, p. 63-69

    Research output: Contribution to journalArticle

  13. 2013
  14. Published

    Selective mitochondrial staining with small fluorescent probes: importance, design, synthesis, challenges and trends for new markers

    Neto, B. AD., Correa, J. R. & Silva, R. G., 2013, In : RSC Advances. 3, p. 5291-5301

    Research output: Contribution to journalArticle

  15. Published

    The Biginelli reaction with an imidazolium-tagged recyclable iron catalyst: kinetics, mechanism, and antitumoral activity

    Ramos, L. M., Guido, B. C., Nobrega, C. C., Correa, J. R., Silva, R. G., de Oliveira, H. CB., Gomes, A. F., Gozzo, F. C. & Neto, B. AD., 2013, In : Chemistry - A European Journal. 19, p. 4156-4168

    Research output: Contribution to journalArticle

  16. 2012
  17. Published

    Constrained bonding environment in the Michaelis complex of Trypanosoma cruzi uridine phosphorylase

    Silva, R. G., Kipp, D. R. & Schramm, V. L., 2012, In : Biochemistry. 51, p. 6715-6717

    Research output: Contribution to journalArticle

  18. Published

    Synthesis, properties and highly selective mitochondria staining with novel, stable and superior benzothiadiazole fluorescent probes

    Neto, B. AD., Carvalho, P. HPR., Santos, D. CBD., Gatto, C. C., Ramos, L. M., de Vasconcelos, N. M., Correa, J. R., Costa, M. B., de Oliveira, H. CB. & Silva, R. G., 2012, In : RSC Advances. 2, p. 1524-1532

    Research output: Contribution to journalArticle

  19. 2011
  20. Published

    Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase

    Silva, R. G., Hirschi, J. S., Ghanem, M., Murkin, A. S. & Schramm, V. L., 2011, In : Biochemistry. 50, p. 2701-2709

    Research output: Contribution to journalArticle

  21. Published
  22. Published

    Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease

    Kipp, D. R., Silva, R. G. & Schramm, V. L., 2011, In : Journal of the American Chemical Society. 133, p. 19358-19361

    Research output: Contribution to journalArticle

  23. Published

    Transition-state analysis of Trypanosoma cruzi uridine phosphorylase-catalyzed arsenolysis of uridine

    Silva, R. G., Vetticatt, M. J., Merino, E. F., Cassera, M. B. & Schramm, V. L., 2011, In : Journal of the American Chemical Society. 133, p. 9923-9931

    Research output: Contribution to journalArticle

  24. Published

    Uridine phosphorylase from Trypanosoma cruzi: kinetic and chemical mechanisms

    Silva, R. G. & Schramm, V. L., 2011, In : Biochemistry. 50, p. 9158-9166

    Research output: Contribution to journalArticle

  25. 2010
  26. Published

    Purine nucleoside phosphorylase activity and expression are upregulated in sites affected by periodontal disease

    Batista Jr, E. L., Deves, C., Ayub, L., da Silva, R. G., Filho, LCC., Basso, L. A. & Santos, D. S., 2010, In : Journal of Periodontal Research. 45, p. 664–671

    Research output: Contribution to journalArticle

  27. 2008
  28. Published
  29. 2007
  30. Published

    Kinetic and chemical mechanisms of shikimate dehydrogenase from Mycobacterium tuberculosis

    Fonseca, I. O., Silva, R. G., Fernandes, C., de Souza, O. N., Basso, L. A. & Santos, D. S., 2007, In : Archives of Biochemistry and Biophysics. 457, p. 123-133

    Research output: Contribution to journalArticle

  31. Published

    Purine Nucleoside Phosphorylase: A Potential Target for the Development of Drugs to Treat T-Cell- and Apicomplexan Parasite-Mediated Diseases

    Silva, R. G., Nunes, J. E. S., Canduri, F., Borges, J. C., Gava, L. M., Moreno, F. B., Basso, L. A. & Santos, D. S., 2007, In : Current Drug Targets. 8, p. 413-422

    Research output: Contribution to journalArticle

  32. 2006
  33. Published

    Beta-Ketoacyl-Acyl Carrier Protein (ACP) Reductase: Kinetic and Chemical Mechanisms

    Silva, R. G., de Carvalho, L. P. S., Blanchard, J. S., Santos, D. S. & Basso, L. A., 2006, In : Biochemistry. 45, p. 13064-13073

    Research output: Contribution to journalArticle

  34. Published

    Functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv: Purification and characterization

    Fonseca, I. O., Magalhaes, M. L. B., Oliveira, J. S., Silva, R. G., Mendes, M. A., Palma, M. S., Santos, D. S. & Basso, L. A., 2006, In : Protein Expression and Purification. 46, p. 429-437

    Research output: Contribution to journalArticle

  35. 2005
  36. Published

    Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine

    Silva, R. G., Pereira, J. H., Canduri, F., de Azevedo, WF., Basso, LA. & Santos, DS., 2005, In : Archives of Biochemistry and Biophysics. 442, p. 49-58

    Research output: Contribution to journalArticle

  37. Published

    Structure of human PNP complexed with ligands

    Canduri, F., Silva, R. G., dos Santos, D. M., Palma, MS., Basso, LA., Santos, DS. & de Azevedo, WF., 2005, In : Acta Crystallographica. Section D, Biological crystallography. 61, p. 856-862

    Research output: Contribution to journalArticle

  38. 2004
  39. Published

    Purine Nucleoside Phosphorylase Activity in Rat Cerebrospinal Fluid

    Silva, R. G., Santos, DS., Basso, LA., Oses, JP., Wofchuk, S., Portela, LVC. & Souza, DO., 2004, In : Neurochemical Research. 29, p. 1831-1835

    Research output: Contribution to journalArticle

  40. Published

    Structures of human purine nucleoside phosphorylase complexed with inosine and ddI

    Canduri, F., dos Santos, DM., Silva, R. G., Mendes, MA., Basso, LA., MS, P., de Azevedo, WF. & Santos, DS., 2004, In : Biochemical and Biophysical Research Communications. 313, p. 907-914

    Research output: Contribution to journalArticle

  41. 2003
  42. Published

    Cloning, overexpression, and purification of functional human purine nucleoside phosphorylase

    Silva, R. G., de Carvalho, LPS., Oliveira, JS., Pinto, CA., Mendes, MA., Palma, MS., Basso, LA. & Santos, DS., 2003, In : Protein Expression and Purification. 27, p. 158-164

    Research output: Contribution to journalArticle

  43. Published

    Crystal structure of human PNP complexed with guanine

    de Azevedo, WF., Canduri, F., dos Santos, D., Pereira, J., Dias, MVB., Silva, R. G., Mendes, MA., Basso, LA., Palma, MS. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 312, p. 767-772

    Research output: Contribution to journalArticle

  44. Published

    Crystal structure of human purine nucleoside phosphorylase at 2.3 A resolution

    de Azevedo, WF., Canduri, F., dos Santos, DM., Silva, R. G., Oliveira, JS., de Carvalho, LPS., Basso, LA., Mendes, MA., Palma, MS. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 308, p. 545-552

    Research output: Contribution to journalArticle

  45. Published

    Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir

    dos Santos, DM., Canduri, F., Pereira, JH., Dias, MVB., Silva, R. G., Mendes, MA., Palma, MS., Basso, LA., de Azevedo, WF. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 308, p. 553-559

    Research output: Contribution to journalArticle

  46. Published

    Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase

    de Azevedo, WF., dos Santos, G., dos Santos, DM., Olivieri, JR., Canduri, F., Silva, R. G., Basso, LA., Renard, G., Fonseca, IO., Mendes, MA., Palma, MS. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 309, p. 923-928

    Research output: Contribution to journalArticle

  47. Published

    Structural basis for inhibition of human PNP by immucillin-H

    de Azevedo, WF., Canduri, F., dos Santos, DM., Pereira, JH., Dias, MVB., Silva, R. G., Mendes, MA., Basso, LA., Palma, MS. & Santos, DS., 2003, In : Biochemical and Biophysical Research Communications. 309, p. 917–922

    Research output: Contribution to journalArticle

Top