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Research at St Andrews

Samantha J. Pitt

Person

  1. Review article › Research › Peer-reviewed
  2. Published

    Exploring the biophysical evidence that mammalian two pore channels are NAADP-activated calcium-permeable channels

    Pitt, S. J., Reilly O'Donnell, B. & Sitsapesan, R., 1 Aug 2016, In : The Journal of Physiology. 594, 15, p. 4171-4179 9 p.

    Research output: Contribution to journalReview article

  3. Published

    Glycosaminoglycan neutralization in coagulation control

    Sobczak, A. I. S., Pitt, S. J. & Stewart, A. J., Jun 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 6, p. 1258-1270 14 p.

    Research output: Contribution to journalReview article

  4. Published

    Influence of zinc on glycosaminoglycan neutralisation during coagulation

    Sobczak, A. I. S., Pitt, S. J. & Stewart, A. J., Sep 2018, In : Metallomics. 10, 9, p. 1180-1190 11 p.

    Research output: Contribution to journalReview article

  5. Abstract › Research › Peer-reviewed
  6. Published

    Functional characterization of ATP2C2, a risk factor for language disorders

    Martinelli, A., Diaz, R., Feliciotti, I., Pitt, S. & Paracchini, S., 2019, In : European Neuropsychopharmacology. 29, p. 1194-1195 2 p.

    Research output: Contribution to journalAbstract

  7. Published

    TPC1 is a proton permeable channel that can be independently activated by cytosolic calcium or NAADP

    Pitt, S. J., Lam, A., Galione, A. & Sitsapesan, R., 28 Jan 2014, In : Biophysical Journal. 106, 2, p. 642A-642A 1 p.

    Research output: Contribution to journalAbstract

  8. Letter › Research › Peer-reviewed
  9. Published

    Response to Qian and Colvin: zinc-mediated regulation of the cardiac ryanodine receptor occurs via multiple binding sites

    Woodier, J., Rainbow, R. D., Stewart, A. J. & Pitt, S. J., 19 Feb 2016, In : Journal of Biological Chemistry. 291, 8, p. 4267

    Research output: Contribution to journalLetter

  10. Article › Research › Peer-reviewed
  11. Published

    17ß-Estradiol protects against the effects of a high fat diet on cardiac glucose, lipid and nitric oxide metabolism in rats

    Zafirovic, S., Obradovic, M., Sudar-Milovanovic, E., Jovanovic, A., Stanimirovic, J., Stewart, A. J., Pitt, S. J. & Isenovic, E. R., 5 May 2017, In : Molecular and Cellular Endocrinology. 446, p. 12-20 9 p.

    Research output: Contribution to journalArticle

  12. Published

    In vivo effects of 17β-estradiol on cardiac Na+/K+-ATPase expression and activity in rat heart

    Obradovic, M., Stewart, A. J., Pitt, S. J., Labudovic-Borovic, M., Sudar, E., Petrovic, V., Zafirovic, S., Maravic-Stojkovic, V., Vasic, V. & Isenovic, E. R., 5 May 2014, In : Molecular and Cellular Endocrinology. 388, 1-2, p. 58-68

    Research output: Contribution to journalArticle

  13. Published

    A family of Type VI secretion system effector proteins that form ion-selective pores

    Mariano, G., Trunk, K., Williams, D. J., Monlezun, L., Strah, H., Pitt, S. J. & Coulthurst, S. J., 2 Dec 2019, In : Nature Communications. 10, p. 1-15 15 p., 5484.

    Research output: Contribution to journalArticle

  14. Published

    A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats

    Stanimirovic, J., Obradovic, M., Jovanovic, A., Sudar-Milovanovic, E., Zafirovic, S., Pitt, S. J., Stewart, A. J. & Isenovic, E. R., 1 Apr 2016, In : Nitric Oxide. 54, p. 51-59 9 p.

    Research output: Contribution to journalArticle

  15. Published

    Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

    Kapsalis, C., Wang, B., El Mkami, H., Pitt, S. J., Schnell, J., Smith, T. K., Lippiat, J., Bode, B. E. & Pliotas, C., 10 Oct 2019, In : Nature Communications. 10, 14 p., 4619.

    Research output: Contribution to journalArticle

  16. Published

    Ca2+-dependent phosphorylation of RyR2 can uncouple channel gating from direct cytosolic Ca2+ regulation

    Carter, S., Pitt, S. J., Colyer, J. & Sitsapesan, R., 2011, In : Journal of Membrane Biology. 240, 1, p. 21-33

    Research output: Contribution to journalArticle

  17. Published

    Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high fat diet

    Jovanovic, A., Obradovic, M., Sudar-Milovanovic, E., Stewart, A. J., Pitt, S. J., Alvantic, D., Aleksic, E. & Isenovic, E. R., Dec 2017, In : Molecular and Cellular Biochemistry. 436, 1-2, p. 49-58 10 p.

    Research output: Contribution to journalArticle

  18. Published

    Charade of the SR K+-channel: two ion-channels, TRIC-A and TRIC-B, masquerade as a single K+-channel

    Pitt, S. J., Park, K-H., Nishi, M., Urashima, T., Aoki, S., Yamazaki, D., Ma, J., Takeshima, H. & Sitsapesan, R., 2010, In : Biophysical Journal. 99, 2, p. 417-426

    Research output: Contribution to journalArticle

  19. Published

    Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage

    Reilly-O'Donnell, B., Robertson, G. B., Karumbi, A., McIntyre, C., Bal, W., Nishi, M., Takeshima, H., Stewart, A. J. & Pitt, S. J., 11 Aug 2017, In : Journal of Biological Chemistry. 292, 32, p. 13361-13373 13 p.

    Research output: Contribution to journalArticle

  20. Published

    Examining a new role for zinc in regulating calcium release in cardiac muscle

    Pitt, S. J. & Stewart, A. J., 1 Jun 2015, In : Biochemical Society Transactions. 43, 3, p. 359-363

    Research output: Contribution to journalArticle

  21. Published

    FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6

    Galfre, E., Pitt, S. J., Venturi, E., Sitsapesan, M., Zaccai, N. R., Tsaneva-Atanasova, K., O'Neill, S. & Sitsapesan, R., 21 Feb 2012, In : PLoS ONE. 7, 2, e31956.

    Research output: Contribution to journalArticle

  22. Published

    FKBP12.6 activates RyR1: investigating the amino acid residues critical for channel modulation

    Venturi, E., Galfre, E., O'Brien, F., Pitt, S. J., Bellamy, S., Sessions, R. B. & Sitsapesan, R., 18 Feb 2014, In : Biophysical Journal. 106, 4, p. 824-833 10 p.

    Research output: Contribution to journalArticle

  23. Published

    From eggs to hearts: what is the link between cyclic ADP-ribose and ryanodine receptors?

    Venturi, E., Pitt, S. J., Galfre, E. & Sitsapesan, R., 2012, In : Cardiovascular Therapeutics. 30, 2, p. 109-16

    Research output: Contribution to journalArticle

  24. Published

    High intracellular chloride slows the decay of glycinergic currents

    Pitt, S. J., Sivilotti, L. G. & Beato, M. B., Nov 2008, In : The Journal of Neuroscience. 28, 45, p. 11454-11467

    Research output: Contribution to journalArticle

  25. Published

    Influence of a high-fat diet on cardiac iNOS in female rats

    Jovanovic, A., Sudar-Milovanovic, E., Obradovic, M., Pitt, S. J., Stewart, A. J., Zafirovic, S., Stanimirovic, J., Radak, D. & Isenovic, E. R., 2017, In : Current Vascular Pharmacology. 15, 5, p. 491-500 10 p.

    Research output: Contribution to journalArticle

  26. Published

    Intracellular zinc modulates cardiac ryanodine receptor-mediated calcium release

    Woodier, J., Rainbow, R. D., Stewart, A. J. & Pitt, S. J., 10 Jul 2015, In : Journal of Biological Chemistry. 290, 28, p. 17599-17610 12 p.

    Research output: Contribution to journalArticle

  27. Published

    Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis.

    Vial, C., Pitt, S. J., Roberts, J. A., Rolf, M. G., Mahaut-Smith, M. P. & Evans, R. J., 2003, In : Blood. 102, 10, p. 3646-51

    Research output: Contribution to journalArticle

  28. Published

    Mitsugumin 23 forms a massive bowl-shaped assembly and cation-conducting channel.

    Venturi, E., Mio, K., Nishi, M., Ogura, T., Moriya, T., Pitt, S. J., Okuda, K., Kakizawa, S., Sitsapesan, R., Sato, C. & Takeshima, H., 2011, In : Biochemistry. 50, 13, p. 2623-32

    Research output: Contribution to journalArticle

  29. Published

    Modulation of the Neisseria gonorrhoeae drug efflux conduit MtrE

    Tamburrino, G., Llabrés, S., Vickery, O., Pitt, S. J. & Zachariae, U., 6 Dec 2017, In : Scientific Reports. 7, 10 p., 17091.

    Research output: Contribution to journalArticle

  30. Published

    Potentiation of P2Y receptors by physiological elevations of extracellular K+ via a mechanism independent of Ca2+ influx.

    Pitt, S. J., Martinez-Pinna, J., Barnard, E. A. & Mahaut-Smith, M. P., 2005, In : Molecular Pharmacology. 67, 5, p. 1705-13

    Research output: Contribution to journalArticle

  31. Published

    Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+

    Pitt, S. J., Lam, A. K. M., Rietdorf, K., Galione, A. & Sitsapesan, R., 20 May 2014, In : Science Signaling. 7, 326, ra46.

    Research output: Contribution to journalArticle

  32. Forthcoming

    Reduced plasma magnesium levels in type-1 diabetes associate with prothrombotic changes in fibrin clotting and fibrinolysis

    Sobczak, A. I. S., Phoenix, F. A., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., 11 Nov 2019, (Accepted/In press) In : Thrombosis and Haemostasis.

    Research output: Contribution to journalArticle

  33. Published

    TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

    Pitt, S. J., Funnell, T. M., Sitsapesan, M., Venturi, E., Rietdorf, K., Ruas, M., Ganesan, A., Gosain, R., Churchill, G. C., Zhu, M. X., Parrington, J., Galione, A. & Sitsapesan, R., 5 Nov 2010, In : Journal of Biological Chemistry. 285, 45, p. 35039-35046

    Research output: Contribution to journalArticle

  34. Published

    TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model

    Venturi, E., Matyjaszkiewicz, A., Pitt, S. J., Tsaneva-Atanasova, K., Nishi, M., Yamazaki, D., Takeshima, H. & Sitsapesan, R., Aug 2013, In : Pflügers Archiv: European Journal of Physiology. 465, 8, p. 1135-1148

    Research output: Contribution to journalArticle

  35. Published

    Total plasma magnesium, zinc, copper and selenium concentrations in type-I and type-II diabetes

    Sobczak, A. I. S., Stefanowicz, F., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., Feb 2019, In : BioMetals. 32, 1, p. 123-138 16 p.

    Research output: Contribution to journalArticle

  36. Published

    Zinc controls RyR2 activity during excitation-contraction coupling

    Stewart, A. J. & Pitt, S. J., Sep 2015, In : Channels. 9, 5, p. 223-225

    Research output: Contribution to journalArticle

  37. Article › Research › Not peer-reviewed
  38. Published

    Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

    Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 28 Aug 2019, In : biorxiv. 38 p.

    Research output: Contribution to journalArticle

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