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Research at St Andrews

Tracey Gloster

Person

  1. 2018
  2. Published

    Linear Eyring plots conceal a change in rate-limiting step in an enzyme reaction

    Machado, T. F. G., Gloster, T. & da Silva, R. G., 11 Dec 2018, In : Biochemistry. 57, 49, p. 6757-6761

    Research output: Contribution to journalArticle

  3. Published

    Metabolic inhibitors of O-GlcNAc transferase (OGT) that act in vivo implicate decreased O-GlcNAc levels in leptin-mediated nutrient sensing

    Liu, T., Zandberg, W. F., Gloster, T. M., Deng, L., Murray, K. D., Shan, X. & Vocadlo, D. J., 25 Jun 2018, In : Angewandte Chemie International Edition. 57, 26, p. 7644-7648

    Research output: Contribution to journalArticle

  4. E-pub ahead of print

    New irreversible α-ʟ-iduronidase inhibitors and activity-based probes

    Artola, M., Kuo, C-L., McMahon, S. A., Oehler, V., Hansen, T., van der Lienden, M., He, X., van den Elst, H., Florea, B. I., Kermode, A. R., van der Marel, G. A., Gloster, T. M., Codée, J. D. C., Overkleeft, H. S. & Aerts, J. M. F. G., 26 Nov 2018, In : Chemistry - A European Journal. Early View, 9 p.

    Research output: Contribution to journalArticle

  5. Published

    Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level

    Ren, W., Pengelly, R. J., Farren-Dai, M., Abadi, S. S. K., Oehler, V., Akintola, O., Draper, J., Meanwell, M., Chakladar, S., Swiderek, K., Moliner, V., Britton, R., Gloster, T. & Bennet, A., 13 Aug 2018, In : Nature Communications. 9, 12 p., 3243.

    Research output: Contribution to journalArticle

  6. 2017
  7. Published

    The enzymatic degradation of heparan sulfate

    Griffin, L. S. & Gloster, T. M., 1 Aug 2017, In : Protein & Peptide Letters. 24, 8, p. 710-722

    Research output: Contribution to journalReview article

  8. 2016
  9. Published

    Mechanism of the human nucleocytoplasmic hexosaminidase D

    Alteen, M. G., Oehler, V., Nemčovičová, I., Wilson, I. B. H., Vacadlo, D. J. & Gloster, T. M., 17 May 2016, In : Biochemistry. 55, 19, p. 2753-2747

    Research output: Contribution to journalArticle

  10. Published

    Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl-carbasugars

    Adamson, C., Pengelly, R. J., Kazem Abadi, S. S., Chakladar, S., Draper, J., Britton, R., Gloster, T. M. & Bennet, A. J., 21 Nov 2016, In : Angewandte Chemie International Edition. 55, 48, p. 14978-14982

    Research output: Contribution to journalArticle

  11. 2014
  12. Published

    Advances in understanding glycosyltransferases from a structural perspective

    Gloster, T. M., Oct 2014, In : Current Opinion in Structural Biology. 28, p. 131-141 11 p.

    Research output: Contribution to journalArticle

  13. 2013
  14. Published

    Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds

    He, X., Pierce, O., Haselhorst, T., Kolarich, D., Packer, N. H., Gloster, T., Vocadlo, D. J., Qian, Y., Brooks, D. & Kermode, A. R., Dec 2013, In : Plant Biotechnology Journal. 11, 9, p. 1034–1043

    Research output: Contribution to journalArticle

  15. Published

    The development of selective inhibitors of NagZ: increased susceptibility of Gram-negative bacteria to β-lactams

    Stubbs, K. A., Bacik, J-P., Perley-Robertson, G. E., Whitworth, G. E., Gloster, T. M., Vocadlo, D. J. & Mark, B. L., Oct 2013, In : ChemBioChem. 14, 15, p. 1973-1981

    Research output: Contribution to journalArticle

  16. 2012
  17. Published

    Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

    Gloster, T. M. & Vocadlo, D. J., Aug 2012, In : Nature Chemical Biology. 8, 8, p. 683-694 12 p.

    Research output: Contribution to journalReview article

  18. Published

    Development of inhibitors as research tools for carbohydrate-processing enzymes

    Gloster, T. M., Oct 2012, In : Biochemical Society Transactions. 40, p. 913-928 16 p.

    Research output: Contribution to journalArticle

  19. Published

    How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity

    Cuskin, F., Flint, J. E., Gloster, T. M., Morland, C., Basle, A., Henrissat, B., Coutinho, P. M., Strazzulli, A., Solovyova, A. S., Davies, G. J. & Gilbert, H. J., 18 Dec 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 51, p. 20889-20894 6 p.

    Research output: Contribution to journalArticle

  20. Published
  21. Published

    Production of alpha-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease

    He, X., Haselhorst, T., von Itzstein, M., Kolarich, D., Packer, N. H., Gloster, T. M., Vocadlo, D. J., Clarke, L. A., Qian, Y. & Kermode, A. R., Sep 2012, In : Nature Communications. 3, p. - 9 p., 1062.

    Research output: Contribution to journalArticle

  22. Published

    Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

    Thompson, A. J., Williams, R. J., Hakki, Z., Alonzi, D. S., Wennekes, T., Gloster, T. M., Songsrirote, K., Thomas-Oates, J. E., Wrodnigg, T. M., Spreitz, J., Stuetz, A. E., Butters, T. D., Williams, S. J. & Davies, G. J., 17 Jan 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 781-786 6 p.

    Research output: Contribution to journalArticle

  23. Published

    Structural snapshots of the reaction coordinate for O-GlcNAc transferase

    Lazarus, M. B., Jiang, J., Gloster, T. M., Zandberg, W. F., Whitworth, G. E., Vocadlo, D. J. & Walker, S., Dec 2012, In : Nature Chemical Biology. 8, 12, p. 966-968 3 p.

    Research output: Contribution to journalArticle

  24. 2011
  25. Published

    6 ''-Azido-6 ''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate

    Mayer, A., Gloster, T. M., Chou, W. K., Vocadlo, D. J. & Tanner, M. E., 15 Feb 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 4, p. 1199-1201 3 p.

    Research output: Contribution to journalArticle

  26. Published

    Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

    Gloster, T. M., Zandberg, W. F., Heinonen, J. E., Shen, D. L., Deng, L. & Vocadlo, D. J., Mar 2011, In : Nature Chemical Biology. 7, 3, p. 174-181 8 p.

    Research output: Contribution to journalArticle

  27. Published

    Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses

    He, Y., Bubb, A. K., Stubbs, K. A., Gloster, T. M. & Davies, G. J., Mar 2011, In : Amino Acids. 40, 3, p. 829-839 11 p.

    Research output: Contribution to journalArticle

  28. 2010
  29. Published

    Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

    Cardona, F., Goti, A., Parmeggiani, C., Parenti, P., Forcella, M., Fusi, P., Cipolla, L., Roberts, S. M., Davies, G. J. & Gloster, T. M., 2010, In : Chemical Communications. 46, 15, p. 2629-2631 3 p.

    Research output: Contribution to journalArticle

  30. Published

    Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis

    Macauley, M. S., Shan, X., Yuzwa, S. A., Gloster, T. M. & Vocadlo, D. J., 24 Sep 2010, In : Chemistry and Biology. 17, 9, p. 949-958 10 p.

    Research output: Contribution to journalArticle

  31. Published

    Glycosidase inhibition: assessing mimicry of the transition state

    Gloster, T. M. & Davies, G. J., 2010, In : Organic & Biomolecular Chemistry. 8, 2, p. 305-320 16 p.

    Research output: Contribution to journalReview article

  32. Published

    Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

    Macauley, M. S., He, Y., Gloster, T. M., Stubbs, K. A., Davies, G. J. & Vocadlo, D. J., 24 Sep 2010, In : Chemistry and Biology. 17, 9, p. 937-948 12 p.

    Research output: Contribution to journalArticle

  33. Published

    Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes

    Gloster, T. M. & Vocadlo, D. J., Jan 2010, In : Current Signal Transduction Therapy. 5, 1, p. 74-91 18 p.

    Research output: Contribution to journalReview article

  34. Published

    Signature Active Site Architectures Illuminate the Molecular Basis for Ligand Specificity in Family 35 Carbohydrate Binding Module

    Correia, M. A. S., Abbott, D. W., Gloster, T. M., Fernandes, V. O., Prates, J. A. M., Montanier, C., Dumon, C., Williamson, M. P., Tunnicliffe, R. B., Liu, Z., Flint, J. E., Davies, G. J., Henrissat, B., Coutinho, P. M., Fontes, C. M. G. A. & Gilbert, H. J., 27 Jul 2010, In : Biochemistry. 49, 29, p. 6193-6205 13 p.

    Research output: Contribution to journalArticle

  35. 2009
  36. Published

    Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function

    Montanier, C., van Bueren, A. L., Dumon, C., Flint, J. E., Correia, M. A., Prates, J. A., Firbank, S. J., Lewis, R. J., Grondin, G. G., Ghinet, M. G., Gloster, T. M., Herve, C., Knox, J. P., Talbot, B. G., Turkenburg, J. P., Kerovuo, J., Brzezinski, R., Fontes, C. M. G. A., Davies, G. J., Boraston, A. B. & 1 others, Gilbert, H. J., 3 Mar 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3065-3070 6 p.

    Research output: Contribution to journalArticle

  37. Published

    Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

    Aguilar-Moncayo, M., Gloster, T. M., Turkenburg, J. P., Isabel Garcia-Moreno, M., Ortiz Mellet, C., Davies, G. J. & Garcia Fernandez, J. M., 2009, In : Organic & Biomolecular Chemistry. 7, 13, p. 2738-2747 10 p.

    Research output: Contribution to journalArticle

  38. Published

    Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase

    He, Y., Martinez-Fleites, C., Bubb, A., Gloster, T. M. & Davies, G. J., 31 Mar 2009, In : Carbohyrdate Research. 344, 5, p. 627-631 5 p.

    Research output: Contribution to journalArticle

  39. Published

    Total Syntheses of Casuarine and Its 6-O-alpha-Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families

    Cardona, F., Parmeggiani, C., Faggi, E., Bonaccini, C., Gratteri, P., Sim, L., Gloster, T. M., Roberts, S., Davies, G. J., Rose, D. R. & Goti, A., 2009, In : Chemistry - A European Journal. 15, 7, p. 1627-1636 10 p.

    Research output: Contribution to journalArticle

  40. 2008
  41. Published

    Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut Flora

    Gloster, T. M., Turkenburg, J. P., Potts, J. R., Henrissat, B. & Davies, G. J., 20 Oct 2008, In : Chemistry and Biology. 15, 10, p. 1058-1067 10 p.

    Research output: Contribution to journalArticle

  42. Published

    Molecular Basis for beta-Glucosidase Inhibition by Ring-Modified Calystegine Analogues

    Aguilar, M., Gloster, T. M., Garcia-Moreno, M. I., Mellet, C. O., Davies, G. J., Llebaria, A., Casas, J., Egido-Gabas, M. & Fernandez, J. M. G., 3 Nov 2008, In : ChemBioChem. 9, 16, p. 2612-2618 7 p.

    Research output: Contribution to journalArticle

  43. 2007
  44. Published

    Characterization and three-dimensional structures of two distinct bacterial xyloglucanases from families GH5 and GH12

    Gloster, T. M., Ibatullin, F. M., Macauley, K., Eklof, J. M., Roberts, S., Turkenburg, J. P., Bjornvad, M. E., Jorgensen, P. L., Danielsen, S., Johansen, K. S., Borchert, T. V., Wilson, K. S., Brumer, H. & Davies, G. J., 29 Jun 2007, In : Journal of Biological Chemistry. 282, 26, p. 19177-19189 13 p.

    Research output: Contribution to journalArticle

  45. Published

    D-glucosylated derivatives of isofagomine and noeuromycin and their potential as inhibitors of beta-glycoside hydrolases

    Meloncelli, P. J., Gloster, T. M., Money, V. A., Tarling, C. A., Davies, G. J., Withers, S. G. & Stick, R. V., 2007, In : Australian Journal of Chemistry. 60, 8, p. 549-565 17 p.

    Research output: Contribution to journalArticle

  46. Published

    Glycosidase inhibition: An assessment of the binding of 18 putative transition-state mimics

    Gloster, T. M., Meloncelli, P., Stick, R. V., Zechel, D., Vasella, A. & Davies, G. J., 28 Feb 2007, In : Journal of the American Chemical Society. 129, 8, p. 2345-2354 10 p.

    Research output: Contribution to journalArticle

  47. Published

    Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors

    Gibson, R. P., Gloster, T. M., Roberts, S., Warren, R. A. J., Storch de Gracia, I., Garcia, A., Chiara, J. L. & Davies, G. J., 2007, In : Angewandte Chemie International Edition. 46, 22, p. 4115-4119 5 p.

    Research output: Contribution to journalArticle

  48. Published

    Structural basis for cyclophellitol inhibition of a beta-glucosidase

    Gloster, T. M., Madsen, R. & Davies, G. J., 2007, In : Organic & Biomolecular Chemistry. 5, 3, p. 444-446 3 p.

    Research output: Contribution to journalArticle

  49. Published

    Structure of a carbohydrate esterase from Bacillus anthracis

    Oberbarnscheidt, L., Taylor, E. J., Davies, G. J. & Gloster, T. M., Jan 2007, In : Proteins: Structure, Function and Bioinformatics. 66, 1, p. 250-252 3 p.

    Research output: Contribution to journalArticle

  50. 2006
  51. Published

    Dissection of conformationally restricted inhibitors binding to a beta-glucosidase

    Gloster, T. M., Madsen, R. & Davies, G. J., May 2006, In : ChemBioChem. 7, 5, p. 738-742 5 p.

    Research output: Contribution to journalArticle

  52. Published

    Structural, kinetic, and thermodynamic analysis of glucoimidazole-derived glycosidase inhibitors

    Gloster, T. M., Roberts, S., Perugino, G., Rossi, M., Moracci, M., Panday, N., Terinek, M., Vasella, A. & Davies, G. J., 3 Oct 2006, In : Biochemistry. 45, 39, p. 11879-11884 6 p.

    Research output: Contribution to journalArticle

  53. Published

    Structure and activity of two metal ion-dependent acetylxylan esterases involved in plant cell wall degradation reveals a close similarity to peptidoglycan deacetylases

    Taylor, E. J., Gloster, T. M., Turkenburg, J. P., Vincent, F., Brzozowski, A. M., Dupont, C., Shareck, F., Centeno, M. S. J., Prates, J. A. M., Puchart, V., Ferreira, L. M. A., Fontes, C. M. G. A., Biely, P. & Davies, G. J., 21 Apr 2006, In : Journal of Biological Chemistry. 281, 16, p. 10968-10975 8 p.

    Research output: Contribution to journalArticle

  54. 2005
  55. Published

    Insights into the structural determinants of cohesin dockerin specificity revealed by the crystal structure of the type II cohesin from Clostridium thermocellum SdbA

    Carvalho, A. L., Pires, V. M. R., Gloster, T. M., Turkenburg, J. P., Prates, J. A. M., Ferreira, L. M. A., Romao, M. J., Davies, G. J., Fontes, C. M. G. A. & Gilbert, H. J., 24 Jun 2005, In : Journal of Molecular Biology. 349, 5, p. 909-915 7 p.

    Research output: Contribution to journalArticle

  56. Published

    Recent structural insights into the expanding world of carbohydrate-active enzymes

    Davies, G. J., Gloster, T. M. & Henrissat, B., Dec 2005, In : Current Opinion in Structural Biology. 15, 6, p. 637-645 9 p.

    Research output: Contribution to journalArticle

  57. 2004
  58. Published

    Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A

    Gloster, T. M., Williams, S. J., Roberts, S., Tarling, C. A., Wicki, J., Withers, S. G. & Davies, G. J., 2004, In : Chemical Communications. 16, p. 1794-1795 2 p.

    Research output: Contribution to journalArticle

  59. Published

    Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis

    Vincent, F., Gloster, T. M., Macdonald, J., Morland, C., Stick, R. V., Dias, F. M. V., Prates, J. A. M., Fontes, C. M. G. A., Gilbert, H. J. & Davies, G. J., 5 Nov 2004, In : ChemBioChem. 5, 11, p. 1596-1599 4 p.

    Research output: Contribution to journalArticle

  60. Published

    Structural and biochemical analysis of Cellvibrio japonicus xylanase 10C - How variation in substrate-binding cleft influences the catalytic profile of family GH-10 xylanases

    Pell, G., Szabo, L., Charnock, S. J., Xie, H. F., Gloster, T. M., Davies, G. J. & Gilbert, H. J., 19 Mar 2004, In : Journal of Biological Chemistry. 279, 12, p. 11777-11788 12 p.

    Research output: Contribution to journalArticle

  61. Published

    Structural studies of the beta-glycosidase from Sulfolobus solfataricus in complex with covalently and noncovalently bound inhibitors

    Gloster, T. M., Roberts, S., Ducros, V. M. A., Perugino, G., Rossi, M., Hoos, R., Moracci, M., Vasella, A. & Davies, G. J., 25 May 2004, In : Biochemistry. 43, 20, p. 6101-6109 9 p.

    Research output: Contribution to journalArticle

  62. Published

    Structural, thermodynamic, and kinetic analyses of tetrahydrooxazine-derived inhibitors bound to beta-glucosidases

    Gloster, T. M., Macdonald, J. M., Tarling, C. A., Stick, R. V., Withers, S. G. & Davies, G. J., 19 Nov 2004, In : Journal of Biological Chemistry. 279, 47, p. 49236-49242 7 p.

    Research output: Contribution to journalArticle

  63. Published

    The mechanisms by which family 10 glycoside hydrolases bind decorated substrates

    Pell, G., Taylor, E. J., Gloster, T. M., Turkenburg, J. P., Fontes, C. M. G. A., Ferreira, L. M. A., Nagy, T., Clark, S. J., Davies, G. J. & Gilbert, H. J., 5 Mar 2004, In : Journal of Biological Chemistry. 279, 10, p. 9597-9605 9 p.

    Research output: Contribution to journalArticle

  64. 2003
  65. Published

    A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer

    Gloster, T., Williams, S. J., Tarling, C. A., Roberts, S., Dupont, C., Jodoin, P., Shareck, F., Withers, S. G. & Davies, G. J., 2003, In : Chemical Communications. 8, p. 944-945 2 p.

    Research output: Contribution to journalArticle

  66. Published

    Iminosugar glycosidase inhibitors: Structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases

    Zechel, D. L., Boraston, A. B., Gloster, T., Boraston, C. M., Macdonald, J. M., Tilbrook, D. M. G., Stick, R. V. & Davies, G. J., 26 Nov 2003, In : Journal of the American Chemical Society. 125, 47, p. 14313-14323 11 p.

    Research output: Contribution to journalArticle

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