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Research at St Andrews

validating choline metabolism as a drug target in the fight against T Brucei

Project: Standard

  1. 2019
  2. Published

    Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei

    Dickie, E. A., Young, S. A. & Smith, T. K., Apr 2019, In: Parasitology. 146, 5, p. 604-616 13 p.

    Research output: Contribution to journalArticlepeer-review

  3. 2018
  4. Published

    The hydrophobic region of the Leishmania peroxin 14: requirements for association with a glycosome mimetic membrane

    Cyr, N., Smith, T. K., Boisselier, É., Leroux, L-P., Kottarampatel, A. H., Davidsen, A., Salesse, C. & Jardim, A., 31 Jan 2018, In: Biochemical Journal. 475, 2, p. 511-529 19 p.

    Research output: Contribution to journalArticlepeer-review

  5. 2013
  6. Published

    A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro

    Zhou, L., Stewart, G., Rideau, E., Westwood, N. J. & Smith, T. K., 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 796–806 11 p.

    Research output: Contribution to journalArticlepeer-review

  7. 2012
  8. Published

    Functional analysis of Leishmania cyclopropane fatty acid synthetase

    Oyola, S. O., Evans, K. J., Smith, T. K., Smith, B. A., Hilley, J. D., Mottram, J. C., Kaye, P. M. & Smith, D. F., 10 Dec 2012, In: PLoS One. 7, 12, 15 p., e51300.

    Research output: Contribution to journalArticlepeer-review

  9. Published

    ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major

    Williams, R. A. M., Smith, T. K., Cull, B., Mottram, J. C. & Coombs, G. H., 17 May 2012, In: PLoS Pathogens. 8, 5, 14 p., e1002695.

    Research output: Contribution to journalArticlepeer-review

  10. 2011
  11. Published

    Depletion of Mitochondrial Acyl Carrier Protein in Bloodstream-Form Trypanosoma brucei Causes a Kinetoplast Segregation Defect

    Clayton, A. M., Guler, J. L., Povelones, M. L., Gluenz, E., Gull, K., Smith, T. K., Jensen, R. E. & Englund, P. T., Mar 2011, In: Eukaryotic Cell. 10, 3, p. 286-292 7 p.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    Synthesis and stereochemical assignment of (+)-chamuvarinin

    Florence, G. J., Morris, J. C., Murray, R. G., Osler, J., Vanga, R. R. & Smith, T. K., 4 Feb 2011, In: Organic Letters. 13, 3, p. 514-517 4 p.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Phospholipases A1

    Richmond, G. S. & Smith, T. K., Jan 2011, In: International Journal of Molecular Sciences. 12, 1, p. 588-612 25 p.

    Research output: Contribution to journalReview articlepeer-review

  14. Published

    Symmetrical choline-derived dications display strong anti-kinetoplastid activity

    Ibrahim, H. M. S., Al-Salabi, M. I., El Sabbagh, N., Quashie, N. B., Alkhaldi, A. A. M., Escale, R., Smith, T. K., Vial, H. J. & de Koning, H. P., Jan 2011, In: Journal of Antimicrobial Chemotherapy. 66, 1, p. 111-125 15 p.

    Research output: Contribution to journalArticlepeer-review

  15. Published
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