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3T MRI investigation of cardiac left ventricular structure and function in a UK population: he Tayside screening for the prevention of cardiac events (TASCFORCE) study

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Author(s)

Stephen J. Gandy, Matthew Lambert, Jill Belch, Ian Cavin, Elena Crowe, Roberta Littleford, Jennifer A MacFarlane, Shona Z Matthew, Patricia Martin, R. Stephen Nicholas, Allan Struthers, Frank Sullivan, Shelley A. Waugh, Richard D. White, Jonathan R. Weir-McCall, J. Graeme Houston

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Abstract

Purpose: To scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.

Materials and Methods: A population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady-state free precession (SSFP) LV data in the short-axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.

Results: Mean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2 , end systolic volume index (ESVI) = 22 ± 7 ml/m2 , stroke volume index (SVI) = 49 ± 8 ml/m2 , and LV mass index (LVMI) = 55 ± 12 g/m2 . The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2 , ESVI 21v25 ml/m2 , SVI 46v52 ml/m2 , LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: -2.9 ± 1.3 ml/m2 , females: -3.1 ± 0.8 ml/m2 ; ESVI males: -1.3 ± 0.7 ml/m2 , females: -1.7 ± 0.5 ml/m2 ; SVI males: -1.7 ± 0.9 ml/m2 , females: -1.4 ± 0.6 ml/m2 ; LVMI males: -1.6 ± 1.1 g/m2 , females: -0.2 ± 0.6 g/m2 but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.

Conclusion: LV reference ranges are provided in this population-based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population-based MR research studies that involve the use of 3.0T MRI scanners.

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Original languageEnglish
Pages (from-to)1186-1196
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume44
Issue number5
Early online date3 May 2016
DOIs
Publication statusPublished - Nov 2016

    Research areas

  • Cardiac, MRI, 3.0T, Left ventricle, Population

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