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A biocatalytic approach towards the stereoselective synthesis of protected inositols

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Abstract

A biocatalytic flow system utilising Trypanosoma brucei L-myo-inositol 1-phosphate synthase has been developed to prepare significant quantities of L-myo-inositol 1-phosphate. Using this highly valuable biochemical, we have demonstrated its utility as a viable starting material in a drastically improved and shortened synthesis of a key intermediate in the synthesis of the biologically important myo-inositol derivatives. This biotransformation allows rapid and stereospecific inositol derivatives to be synthesized, on a larger scale than ever before.
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Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalReaction Chemistry and Engineering
Volume2
Issue number1
Early online date12 Dec 2016
DOIs
Publication statusPublished - 1 Feb 2017

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