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A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis

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Author(s)

David W. Manley, John C. Walton

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Abstract

A titania photoredox catalysis protocol was developed for the homocoupling of C-centered radicals derived from carboxylic acids. Intermolecular reactions were generally efficient and selective, furnishing the desired dimers in good yields under mild neutral conditions. Selective cross-coupling with two acids proved unsuccessful. An intramolecular adaptation enabled macrocycles to be prepared, albeit in modest yields.

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Original languageEnglish
Pages (from-to)5394-5397
Number of pages4
JournalOrganic Letters
Volume16
Issue number20
Early online date7 Oct 2014
DOIs
StatePublished - 17 Oct 2014

    Research areas

  • Coupling-reactions, Organic-synthesis, Natural-products, Tertiary-amines, Polymerizations, Photocatalysis, Alkylations

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