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A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

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Author(s)

Samantha E. Russell, Juan María González Carballo, Claudia Orellana-Tavra, David Fairen-Jimenez, Russell E. Morris

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Abstract

Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.

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Original languageEnglish
Pages (from-to)3915-3920
Number of pages6
JournalDalton Transactions
Volume46
Issue number12
Early online date28 Mar 2017
DOIs
Publication statusPublished - 28 Mar 2017

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