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A consecutive process for C–C and C–N bond formation with high enantio-and diastereocontrol: direct reductive amination of chiral ketones using hydrogenation catalysts

Research output: Contribution to journalArticle

DOI

Open Access Status

  • Embargoed (until 10/05/20)

Author(s)

Sophie H. Gilbert, Virginie Viseur, Matthew L. Clarke

School/Research organisations

Abstract

High diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis.
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Details

Original languageEnglish
Pages (from-to)6409-6412
Number of pages4
JournalChemical Communications
Volume55
Issue number45
Early online date10 May 2019
DOIs
Publication statusPublished - 7 Jun 2019

    Research areas

  • Asymmetric hydrogenation, Reductive amination, Homogeneous catalysis

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