We present a biologically-inspired method for object detection which is capable of online and one-shot learning of object appearance. We use a computationally efficient model of V1 keypoints to select object parts with the highest information content and model their surroundings by a simple binary descriptor based on responses of cortical cells. We feed these features into a dynamical neural network which binds compatible features together by employing a Bayesian criterion and a set of previously observed object views. We demonstrate the feasibility of our algorithm for cognitive robotic scenarios by evaluating detection performance on a dataset of common household items.