Skip to content

Research at St Andrews

A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila

Research output: Contribution to journalArticle

Author(s)

H. Babski, T. Jovanic, C. Surel, S. Yoshikawa, M. F. Zwart, J. Valmier, J. B. Thomas, J. Enriquez, P. Carroll, A. Garcès

School/Research organisations

Abstract

Interneurons (INs) coordinate motoneuron activity to generate appropriate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In Drosophila larvae several IN subtypes have been morphologically described and their function well documented. However, the general lack of molecular characterization of those INs prevents the identification of evolutionary counterparts in other animals, limiting our understanding of the principles underlying neuronal circuit organization and function. Here we characterize a restricted subset of neurons in the nerve cord expressing the Maf transcription factor Traffic Jam (TJ). We found that TJ+ neurons are highly diverse and selective activation of these different subtypes disrupts larval body posture and induces specific locomotor behaviors. Finally, we show that a small subset of TJ+ GABAergic INs, singled out by the expression of a unique transcription factors code, controls larval crawling speed.
Close

Details

Original languageEnglish
Article number4796
Number of pages17
JournalNature Communications
Volume10
DOIs
Publication statusPublished - 22 Oct 2019

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae

    Kohsaka, H., Zwart, M. F., Fushiki, A., Fetter, R. D., Truman, J. W., Cardona, A. & Nose, A., 14 Jun 2019, In : Nature Communications. 10, 11 p., 2654.

    Research output: Contribution to journalArticle

  2. Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

    Oswald, M. C., Brooks, P. S., Zwart, M. F., Mukherjee, A., West, R. J., Giachello, C. N., Morarach, K., Baines, R. A., Sweeney, S. T. & Landgraf, M., 17 Dec 2018, In : eLife. 7, 27 p., e39393.

    Research output: Contribution to journalArticle

  3. The serotonergic system tracks the outcomes of actions to mediate short-term motor learning

    Kawashima, T., Zwart, M. F., Yang, C-T., Mensh, B. & Ahrens, M., 3 Nov 2016, In : Cell. 167, 4, p. 933-946 e20.

    Research output: Contribution to journalArticle

  4. Quantitative neuroanatomy for connectomics in Drosophila

    Schneider-Mizell, C., Gerhard, S., Longair, M., Kazimiers, T., Li, F., Zwart, M. F., Champion, A., Midgley, F., Fetter, R., Saalfeld, S. & Cardona, A., 30 Sep 2016, In : eLife. 5, 36 p., e12059.

    Research output: Contribution to journalArticle

  5. Selective inhibition mediates the sequential recruitment of motor pools: Correction

    Zwart, M. F., Pulver, S., Truman, J., Fushiki, A., Cardona, A. & Landgraf, M., 17 Aug 2016, In : Neuron. 91, 4, p. 944

    Research output: Contribution to journalArticle

Related by journal

  1. Nature Communications (Journal)

    Andy Gardner (Reviewer)
    Feb 2018

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Related by journal

  1. A family of Type VI secretion system effector proteins that form ion-selective pores

    Mariano, G., Trunk, K., Williams, D. J., Monlezun, L., Strah, H., Pitt, S. J. & Coulthurst, S. J., 2 Dec 2019, In : Nature Communications. 10, p. 1-15 15 p., 5484.

    Research output: Contribution to journalArticle

  2. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

    Arnold, N. D., Pickworth, J. A., West, L. E., Dawson, S., Carvalho, J. A., Casbolt, H., Braithwaite, A. T., Iremonger, J., Renshall, L., Germaschewski, V., McCourt, M., Bland-Ward, P., Kowash, H., Hameed, A. G., Rothman, A. M. K., Frid, M. G., Roger Thompson, A. A., Evans, H. R., Southwood, M., Morrell, N. W. & 7 others, Crossman, D. C., Whyte, M. K. B., Stenmark, K. R., Newman, C. M., Kiely, D. G., Francis, S. E. & Lawrie, A., 15 Nov 2019, In : Nature Communications. 10, 18 p., 5183.

    Research output: Contribution to journalArticle

  3. Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets

    Kapsalis, C., Wang, B., El Mkami, H., Pitt, S. J., Schnell, J., Smith, T. K., Lippiat, J., Bode, B. E. & Pliotas, C., 10 Oct 2019, In : Nature Communications. 10, 14 p., 4619.

    Research output: Contribution to journalArticle

  4. An oxalate cathode for lithium ion batteries with combined cationic and polyanionic redox

    Yao, W., Armstrong, A. R., Zhou, X., Sougrati, M-T., Kidkhunthod, P., Tunmee, S., Sun, C., Sattayaporn, S., Lightfoot, P., Ji, B., Jiang, C., Wu, N., Tang, Y. & Cheng, H-M., 2 Aug 2019, In : Nature Communications. 10, 9 p., 3483.

    Research output: Contribution to journalArticle

ID: 262577022

Top