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A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen

Research output: Contribution to journalArticle

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Author(s)

Gavin J. Harkness, Matthew Lee Clarke

School/Research organisations

Abstract

A highly enantioselective synthesis of (S)-Flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1'-biphenyl is shown. [PdCl2((S)-Xylyl-Phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
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Original languageEnglish
Pages (from-to)4859-4863
Number of pages5
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number32
Early online date31 Aug 2017
DOIs
StatePublished - 1 Sep 2017

    Research areas

  • Palladium, Asymmetric catalysis, Carbonylation, Hydroesterification, Hydroxycarbonylation

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