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A Luminescent Amine-Functionalized Metal-Organic Framework Conjugated with Folic Acid as a Targeted Biocompatible pH-Responsive Nanocarrier for Apoptosis Induction in Breast Cancer Cells

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Author(s)

Reza Abazari, Farangis Ataei, Ali Morsali, Alexandra M. Z. Slawin, Cameron L. Carpenter-Warren

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Abstract

Folic acid amine-functionalized metal-organic framework (FOLA@NH2-Eu:TMU-62) with luminescent properties loaded with 5-fluorouracil (5-Fu), as an anticancer medication, was used to construct a new cancer targeted drug delivery system in the present study. The 5-Fu release from this targeted carrier along with MTT assay and trypan blue dye exclusion test results also exhibited pH-controlled characteristics of the given carrier in acidic environments, which is very suitable for targeting solid tumors. Then, the inhibitory action of 5-Fu-loaded FOLA@NH2-Eu:TMU-62 for Michigan Cancer Foundation-7 (MCF7) cell migration was explored according to scratch wound healing assays. Based on the results, the FOLA@NH2-Eu:TMU-62 carrier was not toxic for MCF-10A normal cells, but it was significantly toxic for MCF-7 breast cancer ones, revealing that the FOLA@NH2-Eu:TMU-62 carrier could be utilized in accurate cancer treatments through apoptotic pathways with higher reactive oxygen species compared with 5-Fu alone. This cancer-targeted design of FOLA@NH2-Eu:TMU-62 could thus pave the way for synergistic effects of targeting as well as organized release capabilities.

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Details

Original languageEnglish
Pages (from-to)45442-45454
Number of pages13
JournalACS Applied Materials & Interfaces
Volume11
Issue number49
Early online date13 Nov 2019
DOIs
Publication statusPublished - 11 Dec 2019

    Research areas

  • metal-organic framework, targeted design, pH-responsive nanocarrier, breast cancer cells, wound healing, ONE-POT SYNTHESIS, DRUG-DELIVERY, IN-VITRO, NANOPARTICLES, THERAPY, DESIGN

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