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A method for comparing the impact on carcinogenicity of tobacco products: a case study on heated tobacco versus cigarettes

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A method for comparing the impact on carcinogenicity of tobacco products : a case study on heated tobacco versus cigarettes. / Slob, Wout; Soeteman-Hernández, Lya G; Wieneke , Bil; Staal, Yvonne C M; Stephens, William E; Talhout, Reinskje.

In: Risk Analysis, Vol. Early View, 01.05.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Slob, W, Soeteman-Hernández, LG, Wieneke , B, Staal, YCM, Stephens, WE & Talhout, R 2020, 'A method for comparing the impact on carcinogenicity of tobacco products: a case study on heated tobacco versus cigarettes', Risk Analysis, vol. Early View. https://doi.org/10.1111/risa.13482

APA

Slob, W., Soeteman-Hernández, L. G., Wieneke , B., Staal, Y. C. M., Stephens, W. E., & Talhout, R. (2020). A method for comparing the impact on carcinogenicity of tobacco products: a case study on heated tobacco versus cigarettes. Risk Analysis, Early View. https://doi.org/10.1111/risa.13482

Vancouver

Slob W, Soeteman-Hernández LG, Wieneke B, Staal YCM, Stephens WE, Talhout R. A method for comparing the impact on carcinogenicity of tobacco products: a case study on heated tobacco versus cigarettes. Risk Analysis. 2020 May 1;Early View. https://doi.org/10.1111/risa.13482

Author

Slob, Wout ; Soeteman-Hernández, Lya G ; Wieneke , Bil ; Staal, Yvonne C M ; Stephens, William E ; Talhout, Reinskje. / A method for comparing the impact on carcinogenicity of tobacco products : a case study on heated tobacco versus cigarettes. In: Risk Analysis. 2020 ; Vol. Early View.

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@article{be021287ec214381bfef82258b72af76,
title = "A method for comparing the impact on carcinogenicity of tobacco products: a case study on heated tobacco versus cigarettes",
abstract = "Comparing the harmful health effects related to two different tobacco products by applying common risk assessment methods to each individual compound is problematic. We developed a method that circumvents some of these problems by focusing on the change in cumulative exposure (CCE) of the compounds emitted by the two products considered. The method consists of six steps. The first three steps encompass dose‐response analysis of cancer data, resulting in relative potency factors with confidence intervals. The fourth step evaluates emission data, resulting in confidence intervals for the expected emission of each compound. The fifth step calculates the change in CCE, probabilistically, resulting in an uncertainty range for the CCE. The sixth step estimates the associated health impact by combining the CCE with relevant dose‐response information. As an illustrative case study, we applied the method to eight carcinogens occurring both in the emissions of heated tobacco products (HTPs), a novel class of tobacco products, and tobacco smoke. The CCE was estimated to be 10‐ to 25‐fold lower when using HTPs instead of cigarettes. Such a change indicates a substantially smaller reduction in expected life span, based on available dose‐response information in smokers. However, this is a preliminary conclusion, as only eight carcinogens were considered so far. Furthermore, an unfavorable health impact related to HTPs remains as compared to complete abstinence. Our method results in useful information that may help policy makers in better understanding the potential health impact of new tobacco and related products. A similar approach can be used to compare the carcinogenicity of other mixtures.",
keywords = "Tobacco products, Carcinogenicity, Heated tobacco, Cumulative exposure, Relative potency",
author = "Wout Slob and Soeteman-Hern{\'a}ndez, {Lya G} and Bil Wieneke and Staal, {Yvonne C M} and Stephens, {William E} and Reinskje Talhout",
note = "This work was funded by the Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, The Netherlands.",
year = "2020",
month = may,
day = "1",
doi = "10.1111/risa.13482",
language = "English",
volume = "Early View",
journal = "Risk Analysis",
issn = "1539-6924",
publisher = "Wiley-Blackwell",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A method for comparing the impact on carcinogenicity of tobacco products

T2 - a case study on heated tobacco versus cigarettes

AU - Slob, Wout

AU - Soeteman-Hernández, Lya G

AU - Wieneke , Bil

AU - Staal, Yvonne C M

AU - Stephens, William E

AU - Talhout, Reinskje

N1 - This work was funded by the Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, The Netherlands.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Comparing the harmful health effects related to two different tobacco products by applying common risk assessment methods to each individual compound is problematic. We developed a method that circumvents some of these problems by focusing on the change in cumulative exposure (CCE) of the compounds emitted by the two products considered. The method consists of six steps. The first three steps encompass dose‐response analysis of cancer data, resulting in relative potency factors with confidence intervals. The fourth step evaluates emission data, resulting in confidence intervals for the expected emission of each compound. The fifth step calculates the change in CCE, probabilistically, resulting in an uncertainty range for the CCE. The sixth step estimates the associated health impact by combining the CCE with relevant dose‐response information. As an illustrative case study, we applied the method to eight carcinogens occurring both in the emissions of heated tobacco products (HTPs), a novel class of tobacco products, and tobacco smoke. The CCE was estimated to be 10‐ to 25‐fold lower when using HTPs instead of cigarettes. Such a change indicates a substantially smaller reduction in expected life span, based on available dose‐response information in smokers. However, this is a preliminary conclusion, as only eight carcinogens were considered so far. Furthermore, an unfavorable health impact related to HTPs remains as compared to complete abstinence. Our method results in useful information that may help policy makers in better understanding the potential health impact of new tobacco and related products. A similar approach can be used to compare the carcinogenicity of other mixtures.

AB - Comparing the harmful health effects related to two different tobacco products by applying common risk assessment methods to each individual compound is problematic. We developed a method that circumvents some of these problems by focusing on the change in cumulative exposure (CCE) of the compounds emitted by the two products considered. The method consists of six steps. The first three steps encompass dose‐response analysis of cancer data, resulting in relative potency factors with confidence intervals. The fourth step evaluates emission data, resulting in confidence intervals for the expected emission of each compound. The fifth step calculates the change in CCE, probabilistically, resulting in an uncertainty range for the CCE. The sixth step estimates the associated health impact by combining the CCE with relevant dose‐response information. As an illustrative case study, we applied the method to eight carcinogens occurring both in the emissions of heated tobacco products (HTPs), a novel class of tobacco products, and tobacco smoke. The CCE was estimated to be 10‐ to 25‐fold lower when using HTPs instead of cigarettes. Such a change indicates a substantially smaller reduction in expected life span, based on available dose‐response information in smokers. However, this is a preliminary conclusion, as only eight carcinogens were considered so far. Furthermore, an unfavorable health impact related to HTPs remains as compared to complete abstinence. Our method results in useful information that may help policy makers in better understanding the potential health impact of new tobacco and related products. A similar approach can be used to compare the carcinogenicity of other mixtures.

KW - Tobacco products

KW - Carcinogenicity

KW - Heated tobacco

KW - Cumulative exposure

KW - Relative potency

U2 - 10.1111/risa.13482

DO - 10.1111/risa.13482

M3 - Article

VL - Early View

JO - Risk Analysis

JF - Risk Analysis

SN - 1539-6924

ER -

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