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A molecular mechanism for modulating plasma Zn speciation by fatty acids

Research output: Contribution to journalArticle

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Author(s)

Jin Lu, Alan J. Stewart, Darrell Sleep, Peter J. Sadler, Teresa J. T. Pinheiro, Claudia A. Blindauer

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Abstract

Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to an high-affinity inter-domain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.
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Original languageEnglish
Pages (from-to)1454-1457
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number3
Early online date4 Jan 2012
DOIs
Publication statusPublished - 25 Jan 2012

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