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A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

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Christopher S. Bailey, Joseph S. Zarins-Tutt, Matthias Agbo, Hong Gao, Alberto Diego-Taboada, Maoluo Gan, Refaat B. Hamed Farghal, Emily Abraham, Grahame Mackenzie, P. Andrew Evans, Rebecca J. M. Goss

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Abstract

The photoprotection and isolation of marinomycin A using sporopollenin exine capsules (SpECs) derived from the spores of the plant Lycopodium clavatum is described. The marinomycins have a particularly short half-life in natural light, which severely impacts their potential biological utility given that they display potent antibiotic and anticancer activity. The SpEC encapsulation of the marinomycin A dramatically increases the half-life of the polyene macrodiolide to the direct exposure to UV radiation by several orders of magnitude, thereby making this a potentially useful strategy for other light sensitive bioactive agents. In addition, we report that the SpECs can also be used to selectively extract culture broths that contain the marinomycins, which provides a significantly higher recovery than with conventional XAD resins and provides concomitant photoprotection.
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Original languageEnglish
Pages (from-to)7549-7553
Number of pages5
JournalChemical Science
Volume10
Issue number32
Early online date21 May 2019
DOIs
Publication statusPublished - 28 Aug 2019

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