Skip to content

Research at St Andrews

A note on simulating null distributions for G matrix comparisons

Research output: Contribution to journalArticle

DOI

Open Access Status

  • Embargoed (until 22/10/20)

Author(s)

Michael B. Morrissey, Sandra Hangartner, Keyne Monro

School/Research organisations

Abstract

Genetic variances and covariances, summarised in G matrices, are key determinants of the course of adaptive evolution. Consequently, understanding how G matrices vary among populations is critical to answering a variety of questions in evolutionary biology. A method has recently been proposed for generating null distributions of statistics pertaining to differences in G matrices among populations. The general approach facilitated by this method is likely to prove to be very important in studies of the evolution of G. We have identified an issue in the method that will cause it to create null distributions of differences in G matrices that are likely to be far too narrow. The issue arises from the fact that the method as currently used generates null distributions of statistics pertaining to differences in G matrices across populations by simulating breeding value vectors based on G matrices estimated from data, randomising these vectors across populations, and then calculating null values of statistics from G matrices that are calculated directly from the variances and covariances among randomised vectors. This calculation treats breeding values as quantities that are directly measurable, instead of predicted from G matrices that are themselves estimated from patterns of covariance among kin. The existing method thus neglects a major source of uncertainty in Gmatrices, which renders it anticonservative. We first suggest a correction to the method. We then apply the original and modified methods to a very simple instructive scenario. Finally, we demonstrate the use of both methods in the analysis of a real data set.
Close

Details

Original languageEnglish
JournalEvolution
VolumeEarly View
Early online date22 Oct 2019
DOIs
Publication statusE-pub ahead of print - 22 Oct 2019

    Research areas

  • Differentiation, G matrix, Null distribution, Quantitiatve genetics, Tensor analysis

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The role of selection and evolution in changing parturition date in a red deer population

    Bonnet, T., Morrissey, M. B., Morris, A., Morris, S., Clutton-Brock, T. H., Pemberton, J. M. & Kruuk, L. E. B., 5 Nov 2019, In : PLoS Biology. 17, 11, 23 p., e3000493.

    Research output: Contribution to journalArticle

  2. No evidence that warmer temperatures are associated with selection for smaller body sizes

    Siepielski, A. M., Morrissey, M. B., Carlson, S. M., Francis, C. D., Kingsolver, J. G., Whitney, K. D. & Kruuk, L. E. B., 24 Jul 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1907, 10 p., 20191332.

    Research output: Contribution to journalArticle

  3. Natural selection for body shape in resource polymorphic Icelandic Arctic charr

    Franklin, O. D., Skúlason, S., Morrissey, M. B. & Ferguson, M. M., 16 Aug 2018, In : Journal of Evolutionary Biology. Early View, 15 p.

    Research output: Contribution to journalArticle

  4. Quantification and decomposition of environment-selection relationships

    Hunter, D. C., Pemberton, J., Pilkington, J. & Morrissey, M. B., Apr 2018, In : Evolution. 72, 4, p. 851-866

    Research output: Contribution to journalArticle

  5. Fixed-effect variance and the estimation of repeatabilities and heritabilities: issues and solutions

    de Villemereuil, P., Morrissey, M. B., Nakagawa, S. & Schielzeth, H., Apr 2018, In : Journal of Evolutionary Biology. 31, 4, p. 621-632

    Research output: Contribution to journalArticle

Related by journal

  1. Evolution (Journal)

    Michael Blair Morrissey (Member of editorial board)
    1 Jan 2018

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  2. Evolution (Journal)

    Michael Blair Morrissey (Member of editorial board)
    1 Jan 20181 Jan 2021

    Activity: Publication peer-review and editorial work typesEditor of research journal

  3. Evolution (Journal)

    Thomas Robert Meagher (Editor)
    2006 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

Related by journal

  1. Sexual selection in complex communities: integrating interspecific reproductive interference in structured populations

    McDonald, G., Gardner, A. & Pizzari, T., 2 Apr 2019, In : Evolution. Early View, 12 p.

    Research output: Contribution to journalArticle

  2. Social runaway: fisherian elaboration (or reduction) of socially selected traits via indirect genetic effects

    Bailey, N. W. & Kölliker, M., 17 Jul 2019, In : Evolution. Early View, 15 p.

    Research output: Contribution to journalArticle

  3. No effect of intraspecific relatedness on public goods cooperation in a complex community

    O'Brien, S., Hesse, E., Luján, A., Hodgson, D., Gardner, A. & Buckling, A., 29 Apr 2018, In : Evolution. Early View, 9 p.

    Research output: Contribution to journalArticle

  4. Quantification and decomposition of environment-selection relationships

    Hunter, D. C., Pemberton, J., Pilkington, J. & Morrissey, M. B., Apr 2018, In : Evolution. 72, 4, p. 851-866

    Research output: Contribution to journalArticle

ID: 261241882

Top