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A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas

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We describe a flexible and high yielding synthesis of 1,3-disubstituted ureas, that allows for the construction of both symmetrical and unsymmetrical dipeptide ureas, including easy access to 13C labelled ureas, from amino acids and carbon dioxide at atmospheric pressure.



Original languageEnglish
Pages (from-to)5603-5609
Number of pages8
JournalEuropean Journal of Organic Chemistry
Early online date30 Jul 2015
StatePublished - Sep 2015

    Research areas

  • Peptides, Dipeptide, Urea, Isotopic labelling

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