Skip to content

Research at St Andrews

A one-pot synthesis of symmetrical and unsymmetrical dipeptide ureas

Research output: Contribution to journalArticlepeer-review

Author(s)

Antoine Abou Fayad, Cristina Pubill Ulldemolins, Sunil Vishnuprasadji Sharma, David Day, Rebecca Jane Miriam Goss

School/Research organisations

Abstract

We describe a flexible and high yielding synthesis of 1,3-disubstituted ureas, that allows for the construction of both symmetrical and unsymmetrical dipeptide ureas, including easy access to 13C labelled ureas, from amino acids and carbon dioxide at atmospheric pressure.

Close

Details

Original languageEnglish
Pages (from-to)5603-5609
Number of pages8
JournalEuropean Journal of Organic Chemistry
Volume25
Early online date30 Jul 2015
DOIs
Publication statusPublished - Sep 2015

    Research areas

  • Peptides, Dipeptide, Urea, Isotopic labelling

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. SynBio-SynChem approaches to diversifying the pacidamycins through the exploitation of an observed Pictet-Spengler reaction

    Cartmell, C., Abou Fayad, A., Lynch, R., Sharma, S., Hauck, N., Gust, B. & Goss, R. J. M., 15 Feb 2021, In: ChemBioChem. 22, 4, p. 712-716 6 p.

    Research output: Contribution to journalArticlepeer-review

  2. Synthesis and conformational analysis of fluorinated uridine analogues provide insight into a neighbouring-group participation mechanism

    Michailidou, F., Lebl, T., Slawin, A. M. Z., Sharma, S. V., Brown, M. & Goss, R., 25 Nov 2020, In: Molecules. 25, 23, 13 p., 5513.

    Research output: Contribution to journalArticlepeer-review

  3. Natural products incorporating pyrimidine nucleosides

    Michailidou, F., Burnett, D. A., Sharma, S. V., Van Lanen, S. & Goss, R., 20 Feb 2020, Reference module in chemistry, molecular sciences and chemical engineering. Elsevier Inc.

    Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

  4. A marine viral halogenase that iodinates diverse substrates

    Gkotsi, D. S., Ludewig, H., Sharma, S. V., Connolly, J. A., Dhaliwal, J., Wang, Y., Unsworth, W. P., Taylor, R. J. K., McLachlan, M. M. W., Shanahan, S., Naismith, J. H. & Goss, R. J. M., 14 Oct 2019, In: Nature Chemistry. 11, 12, p. 1091–1097 7 p.

    Research output: Contribution to journalArticlepeer-review

  5. Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions

    Renault, Y. J. G., Lynch, R., Marelli, E., Sharma, S. V., Pubill Ulldemolins, C., Sharp, J., Cartmell, C., Cárdenas, P. & Goss, R. J. M., 8 Oct 2019, In: Chemical Communications. Advance Article, 4 p.

    Research output: Contribution to journalReview articlepeer-review

Related by journal

  1. Kinetic and Structure-Activity Studies of the Triazolium Ion- catalyzed Intramolecular Stetter Reaction

    Smith, A. D., Young, C. M. & O'Donoghue, A., 5 May 2021, (Accepted/In press) In: European Journal of Organic Chemistry.

    Research output: Contribution to journalArticlepeer-review

  2. Planar and rigid pyrazine based TADF emitter for deep blue bright organic light emitting diodes

    Rajamalli, P., Chen, D., Madayanad Suresh, S., Tsuchiya, Y., Adachi, C. & Zysman-Colman, E., 28 Apr 2021, In: European Journal of Organic Chemistry. 2021, 16, p. 2285-2293 10 p.

    Research output: Contribution to journalArticlepeer-review

  3. Synthesis, radiosynthesis and in vitro studies on novel hypoxia PET tracers incorporating [18F]FDR

    Zanda, M., Musolino, M., Fleming, I. N., Schweiger, L. F., O’Hagan, D. & Dall’Angelo, S., 22 Feb 2021, In: European Journal of Organic Chemistry. Early View

    Research output: Contribution to journalArticlepeer-review

  4. Phospholane-phosphite ligands for Rh catalyzed enantioselective conjugate addition: unusually reactive catalysts for challenging couplings

    Gilbert, S. H., Fuentes, J. A., Cordes, D. B., Slawin, A. M. Z. & Clarke, M. L., 25 May 2020, In: European Journal of Organic Chemistry. 2020, 20, p. 3071-3076

    Research output: Contribution to journalArticlepeer-review

  5. Structure‐based design, synthesis and biological evaluation of bis‐tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase

    Zacharova, M., Tulloch, L., Gould, E., Fraser, A., King, E., Menzies, S., Smith, T. K. & Florence, G. J., 1 Sep 2019, In: European Journal of Organic Chemistry. 2019, 31-32, p. 5434-5440 8 p.

    Research output: Contribution to journalArticlepeer-review

ID: 197715351

Top