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A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men

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Author(s)

Adora M. W. Yau, John McLaughlin, Ronald J. Maughan, William Gilmore, Jason J. Ashworth, Gethin H. Evans

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Abstract

Gastric emptying rate in humans is subject to large individual variability, but previous research on the influence of genetics is scarce. Variation in the glucagon-like peptide-1 receptor (GLP1R) gene is a plausible candidate gene to partially explain the high variance. This study aimed to investigate the influence of genetic variation in the GLP1R gene on gastric emptying rate of a glucose solution in humans. Forty eight healthy Caucasian males took part in this investigation. Gastric emptying rate of a 6% glucose solution was assessed using the 13C breath test method and a venous blood sample was obtained from each participant. Participants were genotyped for twenty-seven Tag single nucleotide polymorphisms (SNPs) in the GLP1R locus using Sequenom MassARRAY iPLEX GOLD analysis and MALDI-TOF mass spectrometry. The time at which maximal emptying rate occurred (Tlag) was faster in participants with the CC genotype than in TT and TC genotypes for SNP rs742764: (Median (quartiles) CC, 35 (30-36) min vs. TT, 43 (39-46) min and TC, 41 (39-45) min; P <0.01). Tlag was also slower in participants with the AA genotype compared to the TT and TA genotypes for SNP rs2254336: (AA, 43 (39-49) min vs. TT, 36 (34-41) min and TA, 39 (35-42) min; P <0.05). Analysis by phenotype also showed differences in half-emptying time (T½) and Tlag for SNPs rs9283907, rs2268657 and rs2254336. Several neighbouring Tag SNPs within the GLP1R gene were found to be associated with gastric emptying rate, and should be further investigated.
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Details

Original languageEnglish
Article number1331
JournalFrontiers in Physiology
Volume9
DOIs
Publication statusPublished - 25 Sep 2018

    Research areas

  • GLP-1 receptor, Single nucleotide polymorphism, Gastric emptying rate, GLP-1, Gastrointestinal motility

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