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A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men

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A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men. / Yau, Adora M. W.; McLaughlin, John; Maughan, Ronald J.; Gilmore, William; Ashworth, Jason J.; Evans, Gethin H.

In: Frontiers in Physiology, Vol. 9, 1331, 25.09.2018.

Research output: Contribution to journalArticlepeer-review

Harvard

Yau, AMW, McLaughlin, J, Maughan, RJ, Gilmore, W, Ashworth, JJ & Evans, GH 2018, 'A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men', Frontiers in Physiology, vol. 9, 1331. https://doi.org/10.3389/fphys.2018.01331

APA

Yau, A. M. W., McLaughlin, J., Maughan, R. J., Gilmore, W., Ashworth, J. J., & Evans, G. H. (2018). A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men. Frontiers in Physiology, 9, [1331]. https://doi.org/10.3389/fphys.2018.01331

Vancouver

Yau AMW, McLaughlin J, Maughan RJ, Gilmore W, Ashworth JJ, Evans GH. A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men. Frontiers in Physiology. 2018 Sep 25;9. 1331. https://doi.org/10.3389/fphys.2018.01331

Author

Yau, Adora M. W. ; McLaughlin, John ; Maughan, Ronald J. ; Gilmore, William ; Ashworth, Jason J. ; Evans, Gethin H. / A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men. In: Frontiers in Physiology. 2018 ; Vol. 9.

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@article{a6f9d4c7e7814c4cb637b29e6868c468,
title = "A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men",
abstract = "Gastric emptying rate in humans is subject to large individual variability, but previous research on the influence of genetics is scarce. Variation in the glucagon-like peptide-1 receptor (GLP1R) gene is a plausible candidate gene to partially explain the high variance. This study aimed to investigate the influence of genetic variation in the GLP1R gene on gastric emptying rate of a glucose solution in humans. Forty eight healthy Caucasian males took part in this investigation. Gastric emptying rate of a 6% glucose solution was assessed using the 13C breath test method and a venous blood sample was obtained from each participant. Participants were genotyped for twenty-seven Tag single nucleotide polymorphisms (SNPs) in the GLP1R locus using Sequenom MassARRAY iPLEX GOLD analysis and MALDI-TOF mass spectrometry. The time at which maximal emptying rate occurred (Tlag) was faster in participants with the CC genotype than in TT and TC genotypes for SNP rs742764: (Median (quartiles) CC, 35 (30-36) min vs. TT, 43 (39-46) min and TC, 41 (39-45) min; P <0.01). Tlag was also slower in participants with the AA genotype compared to the TT and TA genotypes for SNP rs2254336: (AA, 43 (39-49) min vs. TT, 36 (34-41) min and TA, 39 (35-42) min; P <0.05). Analysis by phenotype also showed differences in half-emptying time (T½) and Tlag for SNPs rs9283907, rs2268657 and rs2254336. Several neighbouring Tag SNPs within the GLP1R gene were found to be associated with gastric emptying rate, and should be further investigated.",
keywords = "GLP-1 receptor, Single nucleotide polymorphism, Gastric emptying rate, GLP-1, Gastrointestinal motility",
author = "Yau, {Adora M. W.} and John McLaughlin and Maughan, {Ronald J.} and William Gilmore and Ashworth, {Jason J.} and Evans, {Gethin H.}",
note = "AY was supported by a Manchester Metropolitan University Ph.D. studentship.",
year = "2018",
month = sep,
day = "25",
doi = "10.3389/fphys.2018.01331",
language = "English",
volume = "9",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian Men

AU - Yau, Adora M. W.

AU - McLaughlin, John

AU - Maughan, Ronald J.

AU - Gilmore, William

AU - Ashworth, Jason J.

AU - Evans, Gethin H.

N1 - AY was supported by a Manchester Metropolitan University Ph.D. studentship.

PY - 2018/9/25

Y1 - 2018/9/25

N2 - Gastric emptying rate in humans is subject to large individual variability, but previous research on the influence of genetics is scarce. Variation in the glucagon-like peptide-1 receptor (GLP1R) gene is a plausible candidate gene to partially explain the high variance. This study aimed to investigate the influence of genetic variation in the GLP1R gene on gastric emptying rate of a glucose solution in humans. Forty eight healthy Caucasian males took part in this investigation. Gastric emptying rate of a 6% glucose solution was assessed using the 13C breath test method and a venous blood sample was obtained from each participant. Participants were genotyped for twenty-seven Tag single nucleotide polymorphisms (SNPs) in the GLP1R locus using Sequenom MassARRAY iPLEX GOLD analysis and MALDI-TOF mass spectrometry. The time at which maximal emptying rate occurred (Tlag) was faster in participants with the CC genotype than in TT and TC genotypes for SNP rs742764: (Median (quartiles) CC, 35 (30-36) min vs. TT, 43 (39-46) min and TC, 41 (39-45) min; P <0.01). Tlag was also slower in participants with the AA genotype compared to the TT and TA genotypes for SNP rs2254336: (AA, 43 (39-49) min vs. TT, 36 (34-41) min and TA, 39 (35-42) min; P <0.05). Analysis by phenotype also showed differences in half-emptying time (T½) and Tlag for SNPs rs9283907, rs2268657 and rs2254336. Several neighbouring Tag SNPs within the GLP1R gene were found to be associated with gastric emptying rate, and should be further investigated.

AB - Gastric emptying rate in humans is subject to large individual variability, but previous research on the influence of genetics is scarce. Variation in the glucagon-like peptide-1 receptor (GLP1R) gene is a plausible candidate gene to partially explain the high variance. This study aimed to investigate the influence of genetic variation in the GLP1R gene on gastric emptying rate of a glucose solution in humans. Forty eight healthy Caucasian males took part in this investigation. Gastric emptying rate of a 6% glucose solution was assessed using the 13C breath test method and a venous blood sample was obtained from each participant. Participants were genotyped for twenty-seven Tag single nucleotide polymorphisms (SNPs) in the GLP1R locus using Sequenom MassARRAY iPLEX GOLD analysis and MALDI-TOF mass spectrometry. The time at which maximal emptying rate occurred (Tlag) was faster in participants with the CC genotype than in TT and TC genotypes for SNP rs742764: (Median (quartiles) CC, 35 (30-36) min vs. TT, 43 (39-46) min and TC, 41 (39-45) min; P <0.01). Tlag was also slower in participants with the AA genotype compared to the TT and TA genotypes for SNP rs2254336: (AA, 43 (39-49) min vs. TT, 36 (34-41) min and TA, 39 (35-42) min; P <0.05). Analysis by phenotype also showed differences in half-emptying time (T½) and Tlag for SNPs rs9283907, rs2268657 and rs2254336. Several neighbouring Tag SNPs within the GLP1R gene were found to be associated with gastric emptying rate, and should be further investigated.

KW - GLP-1 receptor

KW - Single nucleotide polymorphism

KW - Gastric emptying rate

KW - GLP-1

KW - Gastrointestinal motility

U2 - 10.3389/fphys.2018.01331

DO - 10.3389/fphys.2018.01331

M3 - Article

VL - 9

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 1331

ER -

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