Skip to content

Research at St Andrews

A randomised, controlled, observer-masked trial of corneal cross-linking for progressive keratoconus in children: the KERALINK protocol

Research output: Contribution to journalArticle

Author(s)

Kashfia Chowdhury, Caroline Dore, Jennifer M. Burr, Catey Bunce, Mathew Raynor, Matthew Edwards, Daniel F. P. Larkin

School/Research organisations

Abstract

Introduction: The KERALINK trial tests the hypothesis that corneal cross-linking (CXL) treatment reduces the progression of keratoconus in comparison to standard care in patients under 17 years old. KERALINK is a randomised controlled, observer-masked, multicentre trial in progressive keratoconus comparing epithelium-off CXL with standard care, including spectacles or contact lenses as necessary for best-corrected acuity.

Methods and analysis: A total of 30 participants will be randomised per group. Eligible participants aged 10-16 years with progressive keratoconus in one or both eyes will be recruited. Following randomisation, participants will be followed up 3-monthly for 18 months. The effect on progression will be determined by K-2 on corneal topography. The primary outcome measure is between-group difference in K-2 at 18 months adjusted for K-2 at baseline examination. Secondary outcomes are the effect of CXL on (1) keratoconus progression, (2) time to keratoconus progression, (3) visual acuity, (4) refraction, (5) apical corneal thickness and (6) adverse events. Patient-reported effects will be explored by questionnaires.

Ethics and dissemination Research Ethics Committee Approval was obtained on 30 June 2016 (ref: 14/LO/1937). Current protocol: V.5.0 (08/11/2017). Study findings will be published in peer-reviewed journals.

Close

Details

Original languageEnglish
Article numbere028761
Number of pages6
JournalBMJ Open
Volume9
Issue number9
DOIs
Publication statusPublished - 12 Sep 2019

    Research areas

  • Cornea, Keratoconus, Progression, Cross linking, Topography

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Five-year outcomes of a randomized trial of treatments for varicose veins

    Brittenden, J., Cooper, D., Dimitrova, M., Scotland, G., Cotton, S. C., Elders, A., MacLennan, G., Ramsay, C. R., Norrie, J., Burr, J. M., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Tassie, E., Francis, J. & 1 others, Campbell, M. K., 5 Sep 2019, In : New England Journal of Medicine. 381, p. 912-922

    Research output: Contribution to journalArticle

  2. Clear lens extraction for the management of primary angle closure glaucoma: surgical technique and refractive outcomes in the EAGLE cohort

    Day, A. C., Cooper, D., Burr, J., Foster, P. J., Friedman, D. S., Gazzard, G., Che-Hamzah, J., Aung, T., Ramsay, C. R. & Azuara-Blanco, A., Dec 2018, In : British Journal of Ophthalmology. 102, 12, p. 1658-1662 5 p.

    Research output: Contribution to journalArticle

  3. Incidence of idiopathic intracranial hypertension in Fife

    Goudie, C., Burr, J. & Blaikie, A., 5 Nov 2018, In : Scottish Medical Journal. OnlineFirst

    Research output: Contribution to journalArticle

  4. Barriers to and enablers of diabetic retinopathy screening attendance: a systematic review of published and grey literature

    Graham-Rowe, E., Lorencatto, F., Lawrenson, J. G., Burr, J. M., Grimshaw, J. M., Ivers, N. M., Presseau, J., Vale, L., Peto, T., Bunce, C. & Francis, J. J., Oct 2018, In : Diabetic Medicine. 35, 10, p. 1308-1319

    Research output: Contribution to journalArticle

  5. Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma - study protocol

    King, A. J., Fernie, G., Azuara-Blanco, A., Burr, J. M., Garway-Heath, T., Sparrow, J. M., Vale, L., Hudson, J., MacLennan, G., McDonald, A., Barton, K. & Norrie, J., 1 Jul 2018, In : British Journal of Ophthalmology. 102, 7, p. 922-928 7 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Communication skills training for the radiotherapy team to manage cancer patients’ emotional concerns: a systematic review

    van Beusekom, M. M., Cameron, J., Bedi, C., Banks, E. & Humphris, G. M., 20 Apr 2019, In : BMJ Open. 9, 11 p., e025420.

    Research output: Contribution to journalReview article

  2. Participatory governance over research in an academic research network: the case of Diabetes Action Canada

    Willison, D. J., Trowbridge, J., Greiver, M., Keshavjee, K., Mumford, D. & Sullivan, F., Apr 2019, In : BMJ Open. 9, 4, 9 p., e026828.

    Research output: Contribution to journalArticle

  3. Protocol for the development of the STrengthening the Reporting of Pharmacogenetic Studies (STROPS) guideline: checklist of items for reporting pharmacogenetic studies

    Richardson, M., Kirkham, J. J., Dwan, K. M., Sloan, D. J., Davies, G. & Jorgensen, A., 11 Jul 2019, In : BMJ Open. 9, 7, 5 p., e030212.

    Research output: Contribution to journalArticle

  4. Simvastatin as a neuroprotective treatment for Parkinson's disease (PD STAT): protocol for a double-blind, randomised, placebo-controlled futility study

    Carroll, C. B., Webb, D., Stevens, K. N., Vickery, J., Eyre, V., Ball, S., Wyse, R., Webber, M., Foggo, A., Zajicek, J., Whone, A. & Creanor, S., 7 Oct 2019, In : BMJ Open. 9, 10, 11 p., e029740.

    Research output: Contribution to journalArticle

ID: 264079894

Top