Skip to content

Research at St Andrews

A roadmap for integrating neuroscience into addiction treatment: a consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine

Research output: Contribution to journalReview article

Author(s)

Antonio Verdejo-Garcia, Valentina Lorenzetti, Victoria Manning, Hugh Piercy, Raimondo Bruno, Rob Hester, David Pennington, Serenella Tolomeo, Shalini Arunogiri, Marsha E. Bates, Henrietta Bowden-Jones, Salvatore Campanella, Stacey B. Daughters, Christos Kouimtsidis, Dan I. Lubman, Dieter J. Meyerhoff, Annaketurah Ralph, Tara Rezapour, Hosna Tavakoli, Mehran Zare-Bidoky & 6 more Anna Zilverstand, Douglas Steele, Scott J. Moeller, Martin Paulus, Alexander Mario Baldacchino, Hamed Ekhtiari

School/Research organisations

Abstract

Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice. We recently launched the Neuroscience Interest Group within the International Society of Addiction Medicine (ISAM-NIG) to promote initiatives to bridge this gap. This article summarizes the ISAM-NIG key priorities and strategies to achieve implementation of addiction neuroscience knowledge and tools for the assessment and treatment of substance use disorders. We cover two assessment areas: cognitive assessment and neuroimaging, and two interventional areas: cognitive training/remediation and neuromodulation, where we identify key challenges and proposed solutions. We reason that incorporating cognitive assessment into clinical settings requires the identification of constructs that predict meaningful clinical outcomes. Other requirements are the development of measures that are easily-administered, reliable, and ecologically-valid. Translation of neuroimaging techniques requires the development of diagnostic and prognostic biomarkers and testing the cost-effectiveness of these biomarkers in individualized prediction algorithms for relapse prevention and treatment selection. Integration of cognitive assessments with neuroimaging can provide multilevel targets including neural, cognitive, and behavioral outcomes for neuroscience-informed interventions. Application of neuroscience-informed interventions including cognitive training/remediation and neuromodulation requires clear pathways to design treatments based on multilevel targets, additional evidence from randomized trials and subsequent clinical implementation, including evaluation of cost-effectiveness. We propose to address these challenges by promoting international collaboration between researchers and clinicians, developing harmonized protocols and data management systems, and prioritizing multi-site research that focuses on improving clinical outcomes.
Close

Details

Original languageEnglish
Article number877
Pages (from-to)1-23
Number of pages23
JournalFrontiers in Psychiatry
Volume10
DOIs
Publication statusPublished - 23 Dec 2019

    Research areas

  • Neuroscience, Addiction medicine, Treatment, Substance use disorder, fMRI, Neuomodulation, Neurophysiological assessment, Cognitive rehabilitation

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Effects of opioid dependence on visuospatial memory and its associations with depression and anxiety

    Tolomeo, S., Davey, F., Steele, J. D. & Baldacchino, A. M., 23 Oct 2019, In : Frontiers in Psychiatry. 10, p. 1-8 8 p., 743.

    Research output: Contribution to journalArticle

  2. Cognitive consequences of opioid use

    Baldacchino, A. M., Steele, D., Davey, F. & Tolomeo, S., 21 Mar 2019, Cognition and Addiction: A Researcher’s Guide from Mechanisms towards Interventions: Section 2: COGNITIVE RISK FACTORS AND CONSEQUENCES OF SUBSTANCE AND BEHAVIORAL ADDICTIONS. Verdejo-Garcia, A. (ed.). 35 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  3. Chronic tobacco smoking and neuropsychological impairments: a systematic review and meta-analysis

    Conti, A. A., McLean, L., Tolomeo, S., Steele, D. & Baldacchino, A. M., Jan 2019, In : Neuroscience and Biobehavioral Reviews. 96, p. 143-154 12 p.

    Research output: Contribution to journalReview article

  4. COVID-19 and substance use disorders: Recommendations to a comprehensive healthcare response. An International Society of Addiction Medicine (ISAM) Practice and Policy Interest Group position paper

    Farhoudian, A., Baldacchino, A. M., Clark, N., Gerra, G., Ekhtiari, H., Dom, G., Mokri, A., Sadeghi, M., Nematollahi, P., Demasi, M., Schütz, C. G., Hashemian, S. M., Tabarsi, P., Galea-Singer, S., Carrà, G., Clausen, T., Kouimtsidis, C., Tolomeo, S., Radfar, S. R. & Razaghi, E. M., 12 Apr 2020, In : Basic and Clinical Neuroscience. Special Issue on COVID-19, p. 129-146 17 p.

    Research output: Contribution to journalReview article

Related by journal

  1. Craving in opioid use disorder: from neurobiology to clinical practice

    Kakko, J., Alho, H., Baldacchino, A. M., Molina, R., Nava, F. A. & Shaya, G., 30 Aug 2019, In : Frontiers in Psychiatry. 10, 12 p., 592.

    Research output: Contribution to journalReview article

  2. Effects of opioid dependence on visuospatial memory and its associations with depression and anxiety

    Tolomeo, S., Davey, F., Steele, J. D. & Baldacchino, A. M., 23 Oct 2019, In : Frontiers in Psychiatry. 10, p. 1-8 8 p., 743.

    Research output: Contribution to journalArticle

  3. Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation

    Young, A., Campbell, E. C., Lynch, S. J., Suckling, J. & Powis, S. J., 13 May 2011, In : Frontiers in Psychiatry. 2, 8 p., 27.

    Research output: Contribution to journalArticle

ID: 265381646

Top