Skip to content

Research at St Andrews

A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Author(s)

Ewan M Harrison, Lucy A Weinert, Matthew T G Holden, John J Welch, Katherine Wilson, Fiona J E Morgan, Simon R Harris, Anette Loeffler, Amanda K Boag, Sharon J Peacock, Gavin K Paterson, Andrew S Waller, Julian Parkhill, Mark A Holmes

School/Research organisations

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a global human health problem causing infections in both hospitals and the community. Companion animals, such as cats, dogs, and horses, are also frequently colonized by MRSA and can become infected. We sequenced the genomes of 46 multilocus sequence type (ST) 22 MRSA isolates from cats and dogs in the United Kingdom and compared these to an extensive population framework of human isolates from the same lineage. Phylogenomic analyses showed that all companion animal isolates were interspersed throughout the epidemic MRSA-15 (EMRSA-15) pandemic clade and clustered with human isolates from the United Kingdom, with human isolates basal to those from companion animals, suggesting a human source for isolates infecting companion animals. A number of isolates from the same veterinary hospital clustered together, suggesting that as in human hospitals, EMRSA-15 isolates are readily transmitted in the veterinary hospital setting. Genome-wide association analysis did not identify any host-specific single nucleotide polymorphisms (SNPs) or virulence factors. However, isolates from companion animals were significantly less likely to harbor a plasmid encoding erythromycin resistance. When this plasmid was present in animal-associated isolates, it was more likely to contain mutations mediating resistance to clindamycin. This finding is consistent with the low levels of erythromycin and high levels of clindamycin used in veterinary medicine in the United Kingdom. This study furthers the "one health" view of infectious diseases that the pathogen pool of human and animal populations are intrinsically linked and provides evidence that antibiotic usage in animal medicine is shaping the population of a major human pathogen.
Close

Details

Original languageEnglish
Article numbere00985-13
Number of pages10
JournalmBio
Volume5
Issue number3
DOIs
Publication statusPublished - 13 May 2014

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus

    Harrison, E. M., Ba, X., Coll, F., Blane, B., Restif, O., Carvell, H., Köser, C. U., Jamrozy, D., Reuter, S., Lovering, A., Gleadall, N., Bellis, K. L., Uhlemann, A. C., Lowy, F. D., Massey, R. C., Grilo, I. R., Sobral, R., Larsen, J., Rhod Larsen, A., Vingsbo Lundberg, C. & 5 othersParkhill, J., Paterson, G. K., Holden, M. T. G., Peacock, S. J. & Holmes, M. A., 24 Jun 2019, In : Nature Microbiology. 15 p.

    Research output: Contribution to journalArticle

  2. Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

    Davies, M. R., McIntyre, L., Mutreja, A., Lacey, J. A., Lees, J. A., Towers, R. J., Duchêne, S., Smeesters, P. R., Frost, H. R., Price, D. J., Holden, M. T. G., David, S., Giffard, P. M., Worthing, K. A., Seale, A. C., Berkley, J. A., Harris, S. R., Rivera-Hernandez, T., Berking, O., Cork, A. J. & 18 othersTorres, R. S. L. A., Lithgow, T., Strugnell, R. A., Bergmann, R., Nitsche-Schmitz, P., Chhatwal, G. S., Bentley, S. D., Fraser, J. D., Moreland, N. J., Carapetis, J. R., Steer, A. C., Parkhill, J., Saul, A., Williamson, D. A., Currie, B. J., Tong, S. Y. C., Dougan, G. & Walker, M. J., Jun 2019, In : Nature Genetics. 51, 6, p. 1035-1043

    Research output: Contribution to journalArticle

  3. Antimicrobial resistance in atopic dermatitis: need for an urgent rethink

    Harkins, C. P., Holden, M. T. G. & Irvine, A. D., Mar 2019, In : Annals of Allergy Asthma & Immunology. 122, 3, p. 236-240 5 p.

    Research output: Contribution to journalArticle

  4. Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States

    Mohamed, N., Timofeyeva, Y., Jamrozy, D., Rojas, E., Hao, L., Silmon de Monerri, N. C., Hawkins, J., Singh, G., Cai, B., Liberator, P., Sebastian, S., Donald, R. G. K., Scully, I. L., Jones, C. H., Creech, C. B., Thomsen, I., Parkhill, J., Peacock, S. J., Jansen, K. U., Holden, M. T. G. & 1 othersAnderson, A. S., 14 Jan 2019, In : PLoS ONE. 14, 1, 33 p., e0208356.

    Research output: Contribution to journalArticle

Related by journal

  1. Mobile-genetic-element-encoded hypertolerance to copper protects Staphylococcus aureus from killing by host phagocytes

    Zapotoczna, M., Riboldi, G. P., Moustafa, A. M., Dickson, E., Narechania, A., Morrissey, J. A., Planet, P. J., Holden, M. T. G., Waldron, K. J. & Geoghegan, J. A., 16 Oct 2018, In : mBio. 9, 5, 15 p., e00550-18.

    Research output: Contribution to journalArticle

  2. The Phytophthora infestans haustorium is a site for secretion of diverse classes of infection-associated proteins

    Wang, S., Welsh, L., Thorpe, P., Whisson, S. C., Boevink, P. C. & Birch, P. R. J., 28 Aug 2018, In : mBio. 9, 4, 14 p., e01216-18.

    Research output: Contribution to journalArticle

  3. Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases

    Björnsdóttir, S., Harris, S. R., Svansson, V., Gunnarsson, E., Sigurðardóttir, Ó. G., Gammeljord, K., Steward, K. F., Newton, J. R., Robinson, C., Charbonneau, A. R. L., Parkhill, J., Holden, M. T. G. & Waller, A. S., 1 Aug 2017, In : mBio. 8, 4, 13 p., e00826-17.

    Research output: Contribution to journalArticle

  4. Whole-genome sequencing for routine pathogen surveillance in public health: a population snapshot of invasive Staphylococcus aureus in Europe

    Aanensen, D. M., Feil, E. J., Holden, M. T. G., Dordel, J., Yeats, C. A., Fedosejev, A., Goater, R., Castillo-Ramírez, S., Corander, J., Colijn, C., Chlebowicz, M. A., Schouls, L., Heck, M., Pluister, G., Ruimy, R., Kahlmeter, G., Åhman, J., Matuschek, E., Friedrich, A. W., Parkhill, J. & 4 othersBentley, S. D., Spratt, B. G., Grundmann, H. & European Staphylococcal Reference Laboratory Working Group, 5 May 2016, In : mBio. 7, 3, p. 1-15 15 p., e00444-16.

    Research output: Contribution to journalArticle

  5. Emergence of a new highly successful acapsular Group A Streptococcus clade of the genotype emm89 in the United Kingdom

    Turner, C. E., Abbott, J., Lamagni, T., Holden, M., David, S., Jones, M. D., Game, L., Efstratiou, A. & Sriskandan, S., Jul 2015, In : mBio. 6, 4, 11 p., e00622-15.

    Research output: Contribution to journalArticle

ID: 119787530