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A Simple and Convenient Method for the Synthesis of N,N-Diaryl Tertiary Amines

Research output: Contribution to journalArticlepeer-review

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Author(s)

Francis S. Wekesa, Neha Phadke, Claire Jahier, David B. Cordes, Michael Findlater

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Abstract

Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants.

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Original languageEnglish
Pages (from-to)1046-1051
Number of pages6
JournalSynthesis
Volume46
Issue number8
DOIs
Publication statusPublished - Apr 2014

    Research areas

  • tertiary amines, DIPEA, alkylation, benzyl halides, ARYL CHLORIDES, ALKYL-HALIDES, SECONDARY-AMINES, N-ALKYLATION, REDUCTION, AMINATION, AMIDES, CATALYSTS, EFFICIENT, COMPLEX

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