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A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage

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Clark D Russell, Ed Whittaker, Dominic P Dee, Eilidh Farquhar, Alba Saenz de Villaverde, Morgan H Evans, Ian F Laurenson, Claire L Mackintosh, Muge Cevik

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Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.


Original languageEnglish
Article numberciaa391
Number of pages4
JournalClinical Infectious Diseases
VolumeAdvance Article
Early online date8 Apr 2020
Publication statusE-pub ahead of print - 8 Apr 2020

    Research areas

  • Hospital-acquired pneumonia, Gram-negative bacteria, Doxycycline, Gentamicin, Antimicrobial stewardship

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