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A synthetic replicator drives a propagating reaction-diffusion front

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A synthetic replicator drives a propagating reaction-diffusion front. / Bottero, Ilaria; Huck, Juergen; Kosikova, Tamara; Philp, Douglas.

In: Journal of the American Chemical Society, Vol. 138, No. 21, 01.06.2016, p. 6723-6726.

Research output: Contribution to journalArticlepeer-review

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Bottero, I, Huck, J, Kosikova, T & Philp, D 2016, 'A synthetic replicator drives a propagating reaction-diffusion front', Journal of the American Chemical Society, vol. 138, no. 21, pp. 6723-6726. https://doi.org/10.1021/jacs.6b03372

APA

Bottero, I., Huck, J., Kosikova, T., & Philp, D. (2016). A synthetic replicator drives a propagating reaction-diffusion front. Journal of the American Chemical Society, 138(21), 6723-6726. https://doi.org/10.1021/jacs.6b03372

Vancouver

Bottero I, Huck J, Kosikova T, Philp D. A synthetic replicator drives a propagating reaction-diffusion front. Journal of the American Chemical Society. 2016 Jun 1;138(21):6723-6726. https://doi.org/10.1021/jacs.6b03372

Author

Bottero, Ilaria ; Huck, Juergen ; Kosikova, Tamara ; Philp, Douglas. / A synthetic replicator drives a propagating reaction-diffusion front. In: Journal of the American Chemical Society. 2016 ; Vol. 138, No. 21. pp. 6723-6726.

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@article{24814e8285d74f71bddf3b4a8e18a808,
title = "A synthetic replicator drives a propagating reaction-diffusion front",
abstract = "A simple synthetic autocatalytic replicator is capable of establishing and driving the propagation of a reaction-diffusion front within a 50 µL syringe. This replicator templates its own synthesis through a 1,3-dipolar cycloaddition reaction between a nitrone component, equipped with a 9-ethynylanthracene optical tag, and a maleimide. Kinetic studies using NMR and UV-Vis spectroscopies confirm that the replicator forms ef-ficiently and with high diastereoselectivity and this rep-lication process brings about a dramatic change in opti-cal properties of the sample – a change in the color of the fluorescence in the sample from yellow to blue. The addition of a small amount of the pre-formed replicator at a specific location within a microsyringe, filled with the reaction building blocks, results in the initiation and propagation of a reaction-diffusion front. The realization of a replicator capable of initiating a reaction-diffusion front provides a platform for the examination of inter-connected replicating networks under non-equilibrium conditions involving diffusion processes.",
author = "Ilaria Bottero and Juergen Huck and Tamara Kosikova and Douglas Philp",
note = "The authors thank EPSRC for postgraduate studentship awards to JH (EP/ E017851/1) and TK (EP/K503162/1).",
year = "2016",
month = jun,
day = "1",
doi = "10.1021/jacs.6b03372",
language = "English",
volume = "138",
pages = "6723--6726",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "AMER CHEMICAL SOC",
number = "21",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A synthetic replicator drives a propagating reaction-diffusion front

AU - Bottero, Ilaria

AU - Huck, Juergen

AU - Kosikova, Tamara

AU - Philp, Douglas

N1 - The authors thank EPSRC for postgraduate studentship awards to JH (EP/ E017851/1) and TK (EP/K503162/1).

PY - 2016/6/1

Y1 - 2016/6/1

N2 - A simple synthetic autocatalytic replicator is capable of establishing and driving the propagation of a reaction-diffusion front within a 50 µL syringe. This replicator templates its own synthesis through a 1,3-dipolar cycloaddition reaction between a nitrone component, equipped with a 9-ethynylanthracene optical tag, and a maleimide. Kinetic studies using NMR and UV-Vis spectroscopies confirm that the replicator forms ef-ficiently and with high diastereoselectivity and this rep-lication process brings about a dramatic change in opti-cal properties of the sample – a change in the color of the fluorescence in the sample from yellow to blue. The addition of a small amount of the pre-formed replicator at a specific location within a microsyringe, filled with the reaction building blocks, results in the initiation and propagation of a reaction-diffusion front. The realization of a replicator capable of initiating a reaction-diffusion front provides a platform for the examination of inter-connected replicating networks under non-equilibrium conditions involving diffusion processes.

AB - A simple synthetic autocatalytic replicator is capable of establishing and driving the propagation of a reaction-diffusion front within a 50 µL syringe. This replicator templates its own synthesis through a 1,3-dipolar cycloaddition reaction between a nitrone component, equipped with a 9-ethynylanthracene optical tag, and a maleimide. Kinetic studies using NMR and UV-Vis spectroscopies confirm that the replicator forms ef-ficiently and with high diastereoselectivity and this rep-lication process brings about a dramatic change in opti-cal properties of the sample – a change in the color of the fluorescence in the sample from yellow to blue. The addition of a small amount of the pre-formed replicator at a specific location within a microsyringe, filled with the reaction building blocks, results in the initiation and propagation of a reaction-diffusion front. The realization of a replicator capable of initiating a reaction-diffusion front provides a platform for the examination of inter-connected replicating networks under non-equilibrium conditions involving diffusion processes.

U2 - 10.1021/jacs.6b03372

DO - 10.1021/jacs.6b03372

M3 - Article

VL - 138

SP - 6723

EP - 6726

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 21

ER -

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