Skip to content

Research at St Andrews

A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma

Research output: Contribution to journalArticle

Standard

A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma. / Gremel, Gabriela; Djureinovic, Dijana; Niinivirta, Marjut; Laird, Alexander; Ljungqvist, Oscar; Johannesson, Henrik; Bergman, Julia; Edqvist, Perk-Henrik; Navani, Sanjay; Khan, Naila; Patil, Tushar; Sivertsson, Åsa; Uhlén, Mathias; Harrison, David James; Ullenhag, Gustav J.; Stewart, Grant D.; Pontén, Fredrik.

In: BMC Cancer, Vol. 17, 9, 04.01.2017.

Research output: Contribution to journalArticle

Harvard

Gremel, G, Djureinovic, D, Niinivirta, M, Laird, A, Ljungqvist, O, Johannesson, H, Bergman, J, Edqvist, P-H, Navani, S, Khan, N, Patil, T, Sivertsson, Å, Uhlén, M, Harrison, DJ, Ullenhag, GJ, Stewart, GD & Pontén, F 2017, 'A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma' BMC Cancer, vol. 17, 9. https://doi.org/10.1186/s12885-016-3030-6

APA

Gremel, G., Djureinovic, D., Niinivirta, M., Laird, A., Ljungqvist, O., Johannesson, H., ... Pontén, F. (2017). A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma. BMC Cancer, 17, [9]. https://doi.org/10.1186/s12885-016-3030-6

Vancouver

Gremel G, Djureinovic D, Niinivirta M, Laird A, Ljungqvist O, Johannesson H et al. A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma. BMC Cancer. 2017 Jan 4;17. 9. https://doi.org/10.1186/s12885-016-3030-6

Author

Gremel, Gabriela ; Djureinovic, Dijana ; Niinivirta, Marjut ; Laird, Alexander ; Ljungqvist, Oscar ; Johannesson, Henrik ; Bergman, Julia ; Edqvist, Perk-Henrik ; Navani, Sanjay ; Khan, Naila ; Patil, Tushar ; Sivertsson, Åsa ; Uhlén, Mathias ; Harrison, David James ; Ullenhag, Gustav J. ; Stewart, Grant D. ; Pontén, Fredrik. / A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma. In: BMC Cancer. 2017 ; Vol. 17.

Bibtex - Download

@article{292a06f2b6704b85b7bcbc5a4b3661ee,
title = "A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma",
abstract = "BackgroundThere is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).MethodsHuman Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a candidate. Patient tissue representing various cancer types was constructed into a tissue microarray (n = 940) and immunohistochemistry used to investigate the specificity of CUBN expression in RCC as compared to other cancers. Two independent RCC cohorts (n = 181; n = 114) were analyzed to further establish the sensitivity of CUBN as RCC-specific marker and to explore if the fraction of RCCs lacking CUBN expression could predict differences in patient survival.ResultsCUBN was identified as highly RCC-specific protein with 58{\%} of all primary RCCs staining positive for CUBN using immunohistochemistry. In venous tumor thrombi and metastatic lesions, the frequency of CUBN expression was increasingly lost. Clear cell RCC (ccRCC) patients with CUBN positive tumors had a significantly better prognosis compared to patients with CUBN negative tumors, independent of T-stage, Fuhrman grade and nodal status (HR 0.382, CI 0.203–0.719, P = 0.003).ConclusionsCUBN expression is highly specific to RCC and loss of the protein is significantly and independently associated with poor prognosis. CUBN expression in ccRCC provides a promising positive prognostic indicator for patients with ccRCC. The high specificity of CUBN expression in RCC also suggests a role as a new diagnostic marker in clinical cancer differential diagnostics to confirm or rule out RCC.",
keywords = "Cubilin, Renal cell carcinoma, Independent prognostic biomarker, Immunohistochemistry",
author = "Gabriela Gremel and Dijana Djureinovic and Marjut Niinivirta and Alexander Laird and Oscar Ljungqvist and Henrik Johannesson and Julia Bergman and Perk-Henrik Edqvist and Sanjay Navani and Naila Khan and Tushar Patil and {\AA}sa Sivertsson and Mathias Uhl{\'e}n and Harrison, {David James} and Ullenhag, {Gustav J.} and Stewart, {Grant D.} and Fredrik Pont{\'e}n",
note = "This work was supported by the Swedish Cancer Society and the Knut and Alice Wallenberg Foundation. The work of DJH and GDS was funded by the Chief Scientist Office (grant number ETM37), Renal Cancer Research Fund and Kidney Cancer Scotland.",
year = "2017",
month = "1",
day = "4",
doi = "10.1186/s12885-016-3030-6",
language = "English",
volume = "17",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma

AU - Gremel, Gabriela

AU - Djureinovic, Dijana

AU - Niinivirta, Marjut

AU - Laird, Alexander

AU - Ljungqvist, Oscar

AU - Johannesson, Henrik

AU - Bergman, Julia

AU - Edqvist, Perk-Henrik

AU - Navani, Sanjay

AU - Khan, Naila

AU - Patil, Tushar

AU - Sivertsson, Åsa

AU - Uhlén, Mathias

AU - Harrison, David James

AU - Ullenhag, Gustav J.

AU - Stewart, Grant D.

AU - Pontén, Fredrik

N1 - This work was supported by the Swedish Cancer Society and the Knut and Alice Wallenberg Foundation. The work of DJH and GDS was funded by the Chief Scientist Office (grant number ETM37), Renal Cancer Research Fund and Kidney Cancer Scotland.

PY - 2017/1/4

Y1 - 2017/1/4

N2 - BackgroundThere is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).MethodsHuman Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a candidate. Patient tissue representing various cancer types was constructed into a tissue microarray (n = 940) and immunohistochemistry used to investigate the specificity of CUBN expression in RCC as compared to other cancers. Two independent RCC cohorts (n = 181; n = 114) were analyzed to further establish the sensitivity of CUBN as RCC-specific marker and to explore if the fraction of RCCs lacking CUBN expression could predict differences in patient survival.ResultsCUBN was identified as highly RCC-specific protein with 58% of all primary RCCs staining positive for CUBN using immunohistochemistry. In venous tumor thrombi and metastatic lesions, the frequency of CUBN expression was increasingly lost. Clear cell RCC (ccRCC) patients with CUBN positive tumors had a significantly better prognosis compared to patients with CUBN negative tumors, independent of T-stage, Fuhrman grade and nodal status (HR 0.382, CI 0.203–0.719, P = 0.003).ConclusionsCUBN expression is highly specific to RCC and loss of the protein is significantly and independently associated with poor prognosis. CUBN expression in ccRCC provides a promising positive prognostic indicator for patients with ccRCC. The high specificity of CUBN expression in RCC also suggests a role as a new diagnostic marker in clinical cancer differential diagnostics to confirm or rule out RCC.

AB - BackgroundThere is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).MethodsHuman Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a candidate. Patient tissue representing various cancer types was constructed into a tissue microarray (n = 940) and immunohistochemistry used to investigate the specificity of CUBN expression in RCC as compared to other cancers. Two independent RCC cohorts (n = 181; n = 114) were analyzed to further establish the sensitivity of CUBN as RCC-specific marker and to explore if the fraction of RCCs lacking CUBN expression could predict differences in patient survival.ResultsCUBN was identified as highly RCC-specific protein with 58% of all primary RCCs staining positive for CUBN using immunohistochemistry. In venous tumor thrombi and metastatic lesions, the frequency of CUBN expression was increasingly lost. Clear cell RCC (ccRCC) patients with CUBN positive tumors had a significantly better prognosis compared to patients with CUBN negative tumors, independent of T-stage, Fuhrman grade and nodal status (HR 0.382, CI 0.203–0.719, P = 0.003).ConclusionsCUBN expression is highly specific to RCC and loss of the protein is significantly and independently associated with poor prognosis. CUBN expression in ccRCC provides a promising positive prognostic indicator for patients with ccRCC. The high specificity of CUBN expression in RCC also suggests a role as a new diagnostic marker in clinical cancer differential diagnostics to confirm or rule out RCC.

KW - Cubilin

KW - Renal cell carcinoma

KW - Independent prognostic biomarker

KW - Immunohistochemistry

U2 - 10.1186/s12885-016-3030-6

DO - 10.1186/s12885-016-3030-6

M3 - Article

VL - 17

JO - BMC Cancer

T2 - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

M1 - 9

ER -

Related by author

  1. Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031

    Sarr, A., Bré, J., Um, I. H., Chan, T. H., Mullen, P., Harrison, D. J. & Reynolds, P. A., 21 May 2019, In : Scientific Reports. 9, 13 p., 7643.

    Research output: Contribution to journalArticle

  2. Raman spectroscopy investigation of biochemical changes in tumor spheroids with aging and after treatment with staurosporine

    Jamieson, L. E., Harrison, D. J. & Campbell, C. J., May 2019, In : Journal of Biophotonics. 12, 5, e201800201.

    Research output: Contribution to journalArticle

  3. Automated tumour budding quantification by machine learning augments TNM staging in muscle-invasive bladder cancer prognosis

    Brieu, N., Gavriel, C., Nearchou, I. P., Harrison, D. J., Schmidt, G. & Caie, P. D., 26 Mar 2019, In : Scientific Reports. 9, 5174.

    Research output: Contribution to journalArticle

Related by journal

  1. Fear of cancer recurrence trajectory during radiation treatment and follow-up into survivorship of patients with breast cancer

    Yang, Y., Cameron, J., Bedi, C. & Humphris, G., 20 Oct 2018, In : BMC Cancer. 18, 9 p., 1002.

    Research output: Contribution to journalArticle

  2. Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients: a cluster preference randomized controlled trial

    Rogers, S. N., Lowe, D., Lowies, C., Yeo, S. T., Allmark, C., Mcavery, D., Humphris, G. M., Flavel, R., Semple, C., Thomas, S. J. & Kanatas, A., 18 Apr 2018, In : BMC Cancer. 18, 10 p., 444.

    Research output: Contribution to journalArticle

  3. Serum and blood based biomarkers for lung cancer screening: a systematic review

    Chu, G. C. W., Lazare, K. & Sullivan, F., 13 Feb 2018, In : BMC Cancer. 18, 6 p., 181.

    Research output: Contribution to journalReview article

ID: 248482316