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Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis

Research output: Contribution to journalArticlepeer-review

Author(s)

M. J. Killip, D. F. Young, B. L. Precious, S. Goodbourn, R. E. Randall

School/Research organisations

Abstract

Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-beta promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade.

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Details

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalJournal of General Virology
Volume93
Issue number2
DOIs
Publication statusPublished - Feb 2012

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