Skip to content

Research at St Andrews

Acute risk factors in fatal opioid overdoses as a result of hypoxia and cardiotoxicity. A systematic review and critical appraisal

Research output: Research - peer-reviewReview article

Abstract

Background: The rates of fatal opioid overdoses (FOO) have increased rapidly over the last 10 years. The actual phenomenon occurs as a result of a toxic opioid effect on the cardiorespiratory system.
Aims: The systematic review aimed to identify the acute risk factors in fatal opioid overdose (FOO) as a result of hypoxia and cardiotoxicity. Methods: A systematic review was undertaken. The selection of papers has utilised rigorous criteria of inclusion/exclusion, controlled for heterogeneity.
Results: A total of thirteen articles met the inclusion criteria. Ten of the thirteen studies included were retrospective and the other three studies employed different designs namely longitudinal cohort, case control and case cohort. Factors that were modestly described with increased acute risk of FOO due to hypoxia and cardiotoxicity include multiple sedative use (opioids and alcohol), reduced tolerance and presence of an acute painful condition.
Conclusion: This systematic review has highlighted the lack of information on acute risk factors of FOO due to hypoxia and cardiotoxicity. Future studies need to explore possible mechanisms underlying cardiotoxicity such as reported changes in arterial stiffness in opioid dependent populations and the unexplored potential effects on endothelial function.
Close

Details

Original languageEnglish
Pages (from-to)33-42
JournalHeroin Addiction and Related Clinical Problems
Volume18
Issue number4
StatePublished - Aug 2016

    Research areas

  • Fatal opioid overdose, Hypoxia, Cardiotoxicity, Acute risk factor

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Engagement in the Overdose RIsk InfOrmatioN (ORION) e-Health tool for opioid overdose prevention and self-efficacy: a preliminary study

    Carrà, G., Crocamo, C., Humphris, G. M., Tabacchi, T., Francesco, B., Neufeind, J., Scherbaum, N. & Baldacchino, A. M. 1 Dec 2017 In : Cyberpsychology, Behavior, and Social Networking. 20, 12, p. 762-768

    Research output: Research - peer-reviewArticle

  2. Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change

    Humphris, G. M., Carra, G., Frisher, M., Neufeind, J., Cecil, J. E., Scherbaum, N., Crome, I. & Baldacchino, A. M. Oct 2017 In : Heroin Addiction and Related Clinical Problems. 19, 5, p. 35-44 10 p.

    Research output: Research - peer-reviewArticle

  3. Neuropsychological functioning and chronic methadone use: a systematic review and meta-analysis

    Baldacchino, A., Armanyous, M., Balfour, D. J. K., Humphris, G. & Matthews, K. Feb 2017 In : Neuroscience and Biobehavioral Reviews. 73, p. 23-38

    Research output: Research - peer-reviewReview article

  4. Decision support in addiction: the development of an e-health tool to assess and prevent risk of fatal overdose. The ORION project

    Baldacchino, A., Crocamo, C., Humphris, G., Neufeind, J., Frisher, M. & Carrà, G. 1 Sep 2016 In : Computer Methods and Programs in Biomedicine. 133, p. 207-216 10 p.

    Research output: Research - peer-reviewArticle

Related by journal

  1. Engagement in an e-Health Tool (ORION) predicts opioid-dependent patient likelihood of behavioural change

    Humphris, G. M., Carra, G., Frisher, M., Neufeind, J., Cecil, J. E., Scherbaum, N., Crome, I. & Baldacchino, A. M. Oct 2017 In : Heroin Addiction and Related Clinical Problems. 19, 5, p. 35-44 10 p.

    Research output: Research - peer-reviewArticle

  2. Staff regard towards working with patients who have co-morbid depression and substance misuse disorders

    Nutt, R. A., Gilchrist, G., Marsa Sambola, F. & Baldacchino, A. M. Apr 2017 In : Heroin Addiction and Related Clinical Problems. 19, 2, p. 5-16

    Research output: Research - peer-reviewArticle

ID: 241581311