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Adherence to cardiovascular medication: a review of systematic reviews

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Adherence to cardiovascular medication : a review of systematic reviews. / Leslie, K.H.; McCowan, C.; Pell, J.P.

In: Journal of Public Health, 29.05.2018.

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Leslie, KH, McCowan, C & Pell, JP 2018, 'Adherence to cardiovascular medication: a review of systematic reviews', Journal of Public Health. https://doi.org/10.1093/pubmed/fdy088

APA

Leslie, K. H., McCowan, C., & Pell, J. P. (2018). Adherence to cardiovascular medication: a review of systematic reviews. Journal of Public Health, [fdy088]. https://doi.org/10.1093/pubmed/fdy088

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Leslie KH, McCowan C, Pell JP. Adherence to cardiovascular medication: a review of systematic reviews. Journal of Public Health. 2018 May 29. fdy088. https://doi.org/10.1093/pubmed/fdy088

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Leslie, K.H. ; McCowan, C. ; Pell, J.P. / Adherence to cardiovascular medication : a review of systematic reviews. In: Journal of Public Health. 2018.

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@article{9cb6aa5f2b064260bbce5720109319f2,
title = "Adherence to cardiovascular medication: a review of systematic reviews",
abstract = "Background: Use of cardiovascular medication has increased over time, especially for primary and secondary prevention, with polypharmacy common. Methods: Review of published systematic reviews of the factors and outcomes associated with adherence to cardiovascular medication using MEDLINE, Embase, CINAHL and PsycINFO databases. Quality was assessed using the AMSTAR tool. Results: Of 789 systematic reviews identified, 45 met the inclusion criteria and passed the quality assessment; 34 focused on factors associated with adherence, and 11 on outcomes. High heterogeneity, both between and within reviews, precluded meta-analysis and so a pooled estimate of adherence levels could not be derived. Adherence was associated with disease factors, therapy factors, healthcare factors, patient factors and social factors, though with some inconsistencies. In total, 91% of reviews addressing outcomes reported that low adherence was associated with poorer clinical and economic endpoints. Conclusions: Factors from across five key domains relate to non-adherence to cardiovascular medications, and may contribute to poorer clinical outcomes. Interventions to improve adherence should be developed to address modifiable factors and targeted at those at highest risk of non-adherence. Adherence research is highly heterogeneous to-date and efforts to standardize this should be implemented to improve comparability.",
keywords = "Behaviour, Circulatory disease, Systematic review",
author = "K.H. Leslie and C. McCowan and J.P. Pell",
note = "Work supported by Medical Research Council (MRC) [MR/N013166/1 to K.H.L.]",
year = "2018",
month = may,
day = "29",
doi = "10.1093/pubmed/fdy088",
language = "English",
journal = "Journal of Public Health",
issn = "1741-3842",
publisher = "Oxford University Press",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Adherence to cardiovascular medication

T2 - a review of systematic reviews

AU - Leslie, K.H.

AU - McCowan, C.

AU - Pell, J.P.

N1 - Work supported by Medical Research Council (MRC) [MR/N013166/1 to K.H.L.]

PY - 2018/5/29

Y1 - 2018/5/29

N2 - Background: Use of cardiovascular medication has increased over time, especially for primary and secondary prevention, with polypharmacy common. Methods: Review of published systematic reviews of the factors and outcomes associated with adherence to cardiovascular medication using MEDLINE, Embase, CINAHL and PsycINFO databases. Quality was assessed using the AMSTAR tool. Results: Of 789 systematic reviews identified, 45 met the inclusion criteria and passed the quality assessment; 34 focused on factors associated with adherence, and 11 on outcomes. High heterogeneity, both between and within reviews, precluded meta-analysis and so a pooled estimate of adherence levels could not be derived. Adherence was associated with disease factors, therapy factors, healthcare factors, patient factors and social factors, though with some inconsistencies. In total, 91% of reviews addressing outcomes reported that low adherence was associated with poorer clinical and economic endpoints. Conclusions: Factors from across five key domains relate to non-adherence to cardiovascular medications, and may contribute to poorer clinical outcomes. Interventions to improve adherence should be developed to address modifiable factors and targeted at those at highest risk of non-adherence. Adherence research is highly heterogeneous to-date and efforts to standardize this should be implemented to improve comparability.

AB - Background: Use of cardiovascular medication has increased over time, especially for primary and secondary prevention, with polypharmacy common. Methods: Review of published systematic reviews of the factors and outcomes associated with adherence to cardiovascular medication using MEDLINE, Embase, CINAHL and PsycINFO databases. Quality was assessed using the AMSTAR tool. Results: Of 789 systematic reviews identified, 45 met the inclusion criteria and passed the quality assessment; 34 focused on factors associated with adherence, and 11 on outcomes. High heterogeneity, both between and within reviews, precluded meta-analysis and so a pooled estimate of adherence levels could not be derived. Adherence was associated with disease factors, therapy factors, healthcare factors, patient factors and social factors, though with some inconsistencies. In total, 91% of reviews addressing outcomes reported that low adherence was associated with poorer clinical and economic endpoints. Conclusions: Factors from across five key domains relate to non-adherence to cardiovascular medications, and may contribute to poorer clinical outcomes. Interventions to improve adherence should be developed to address modifiable factors and targeted at those at highest risk of non-adherence. Adherence research is highly heterogeneous to-date and efforts to standardize this should be implemented to improve comparability.

KW - Behaviour

KW - Circulatory disease

KW - Systematic review

U2 - 10.1093/pubmed/fdy088

DO - 10.1093/pubmed/fdy088

M3 - Review article

JO - Journal of Public Health

JF - Journal of Public Health

SN - 1741-3842

M1 - fdy088

ER -

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