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Ancient homeobox gene loss and the evolution of chordate brain and pharynx development: deductions from amphioxus gene expression

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Ancient homeobox gene loss and the evolution of chordate brain and pharynx development : deductions from amphioxus gene expression. / Butts, Thomas; Holland, Peter W.H.; Ferrier, David Ellard Keith.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 277, No. 1699, 22.11.2010, p. 3381-3389.

Research output: Contribution to journalArticle

Harvard

Butts, T, Holland, PWH & Ferrier, DEK 2010, 'Ancient homeobox gene loss and the evolution of chordate brain and pharynx development: deductions from amphioxus gene expression' Proceedings of the Royal Society B: Biological Sciences, vol. 277, no. 1699, pp. 3381-3389. https://doi.org/10.1098/rspb.2010.0647

APA

Butts, T., Holland, P. W. H., & Ferrier, D. E. K. (2010). Ancient homeobox gene loss and the evolution of chordate brain and pharynx development: deductions from amphioxus gene expression. Proceedings of the Royal Society B: Biological Sciences, 277(1699), 3381-3389. https://doi.org/10.1098/rspb.2010.0647

Vancouver

Butts T, Holland PWH, Ferrier DEK. Ancient homeobox gene loss and the evolution of chordate brain and pharynx development: deductions from amphioxus gene expression. Proceedings of the Royal Society B: Biological Sciences. 2010 Nov 22;277(1699):3381-3389. https://doi.org/10.1098/rspb.2010.0647

Author

Butts, Thomas ; Holland, Peter W.H. ; Ferrier, David Ellard Keith. / Ancient homeobox gene loss and the evolution of chordate brain and pharynx development : deductions from amphioxus gene expression. In: Proceedings of the Royal Society B: Biological Sciences. 2010 ; Vol. 277, No. 1699. pp. 3381-3389.

Bibtex - Download

@article{8fcb57199ac743e0a52b9860b79b40db,
title = "Ancient homeobox gene loss and the evolution of chordate brain and pharynx development: deductions from amphioxus gene expression",
abstract = "Homeobox genes encode a large superclass of transcription factors with widespread roles in animal development. Within chordates there are over 100 homeobox genes in the invertebrate cephalochordate amphioxus and over 200 in humans. Set against this general trend of increasing gene number in vertebrate evolution, some ancient homeobox genes that were present in the last common ancestor of chordates have been lost from vertebrates. Here, we describe the embryonic expression of four amphioxus descendants of these genes—AmphiNedxa, AmphiNedxb, AmphiMsxlx and AmphiNKx7. All four genes are expressed with a striking asymmetry about the left–right axis in the pharyngeal region of neurula embryos, mirroring the pronounced asymmetry of amphioxus embryogenesis. AmphiMsxlx and AmphiNKx7 are also transiently expressed in an anterior neural tube region destined to become the cerebral vesicle. These findings suggest significant rewiring of developmental gene regulatory networks occurred during chordate evolution, coincident with homeobox gene loss. We propose that loss of otherwise widely conserved genes is possible when these genes function in a confined role in development that is subsequently lost or significantly modified during evolution. In the case of these homeobox genes, we propose that this has occurred in relation to the evolution of the chordate pharynx and brain.",
author = "Thomas Butts and Holland, {Peter W.H.} and Ferrier, {David Ellard Keith}",
year = "2010",
month = "11",
day = "22",
doi = "10.1098/rspb.2010.0647",
language = "English",
volume = "277",
pages = "3381--3389",
journal = "Proceedings of the Royal Society B: Biological Sciences",
issn = "0962-8452",
publisher = "Royal Society of London",
number = "1699",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Ancient homeobox gene loss and the evolution of chordate brain and pharynx development

T2 - Proceedings of the Royal Society B: Biological Sciences

AU - Butts, Thomas

AU - Holland, Peter W.H.

AU - Ferrier, David Ellard Keith

PY - 2010/11/22

Y1 - 2010/11/22

N2 - Homeobox genes encode a large superclass of transcription factors with widespread roles in animal development. Within chordates there are over 100 homeobox genes in the invertebrate cephalochordate amphioxus and over 200 in humans. Set against this general trend of increasing gene number in vertebrate evolution, some ancient homeobox genes that were present in the last common ancestor of chordates have been lost from vertebrates. Here, we describe the embryonic expression of four amphioxus descendants of these genes—AmphiNedxa, AmphiNedxb, AmphiMsxlx and AmphiNKx7. All four genes are expressed with a striking asymmetry about the left–right axis in the pharyngeal region of neurula embryos, mirroring the pronounced asymmetry of amphioxus embryogenesis. AmphiMsxlx and AmphiNKx7 are also transiently expressed in an anterior neural tube region destined to become the cerebral vesicle. These findings suggest significant rewiring of developmental gene regulatory networks occurred during chordate evolution, coincident with homeobox gene loss. We propose that loss of otherwise widely conserved genes is possible when these genes function in a confined role in development that is subsequently lost or significantly modified during evolution. In the case of these homeobox genes, we propose that this has occurred in relation to the evolution of the chordate pharynx and brain.

AB - Homeobox genes encode a large superclass of transcription factors with widespread roles in animal development. Within chordates there are over 100 homeobox genes in the invertebrate cephalochordate amphioxus and over 200 in humans. Set against this general trend of increasing gene number in vertebrate evolution, some ancient homeobox genes that were present in the last common ancestor of chordates have been lost from vertebrates. Here, we describe the embryonic expression of four amphioxus descendants of these genes—AmphiNedxa, AmphiNedxb, AmphiMsxlx and AmphiNKx7. All four genes are expressed with a striking asymmetry about the left–right axis in the pharyngeal region of neurula embryos, mirroring the pronounced asymmetry of amphioxus embryogenesis. AmphiMsxlx and AmphiNKx7 are also transiently expressed in an anterior neural tube region destined to become the cerebral vesicle. These findings suggest significant rewiring of developmental gene regulatory networks occurred during chordate evolution, coincident with homeobox gene loss. We propose that loss of otherwise widely conserved genes is possible when these genes function in a confined role in development that is subsequently lost or significantly modified during evolution. In the case of these homeobox genes, we propose that this has occurred in relation to the evolution of the chordate pharynx and brain.

U2 - 10.1098/rspb.2010.0647

DO - 10.1098/rspb.2010.0647

M3 - Article

VL - 277

SP - 3381

EP - 3389

JO - Proceedings of the Royal Society B: Biological Sciences

JF - Proceedings of the Royal Society B: Biological Sciences

SN - 0962-8452

IS - 1699

ER -

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ID: 4103492