Skip to content

Research at St Andrews

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

Research output: Contribution to journalArticle

DOI

Author(s)

Daniela Carulli, Tommaso Pizzorusso, Jessica C. F. Kwok, Elena Putignano, Andrea Poli, Serhiy Forostyak, Melissa Renee Andrews, Sathyaseelan S. Deepa, Tibor T. Glant, James W. Fawcett

School/Research organisations

Abstract

Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity. However the structures in the extracellular matrix that restrict plasticity are unknown. There are many changes in the extracellular matrix as critical periods for plasticity close, including changes in chondroitin sulphate proteoglycan core protein levels, changes in glycosaminoglycan sulphation and the appearance of dense chondroitin sulphate proteoglycan-containing perineuronal nets around many neurons. We show that formation of perineuronal nets is triggered by neuronal production of cartilage link protein Crtl1 (Hapln1), which is up-regulated in the visual cortex as perineuronal nets form during development and after dark rearing. Mice lacking Crtl1 have attenuated perineuronal nets, but the overall levels of chondroitin sulphate proteoglycans and their pattern of glycan sulphation are unchanged. Crtl1 knockout animals retain juvenile levels of ocular dominance plasticity and their visual acuity remains sensitive to visual deprivation. In the sensory pathway, axons in knockout animals but not controls sprout into the party denervated cuneate nucleus. The organization of chondroitin sulphate proteoglycan into perineuronal nets is therefore the key event in the control of central nervous system plasticity by the extracellular matrix.

Close

Details

Original languageEnglish
Pages (from-to)2331-2347
Number of pages17
JournalBrain
Volume133
Issue number8
DOIs
Publication statusPublished - Aug 2010

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by journal

  1. A causal role for the anterior mid-cingulate cortex in negative affect and cognitive control

    Tolomeo, S., Christmas, D., Jentzsch, I., Johnston, B., Sprengelmeyer, R., Matthews, K. & Steele, J. D., Jun 2016, In : Brain. 139, 6, p. 1844-1854 11 p.

    Research output: Contribution to journalArticle

  2. Integrin activation or alpha9 expression allows retinal pigmented epithelial cell adhesion on Bruch's membrane in wet age-related macular degeneration

    Afshari, F. T., Kwok, J. C., Andrews, M. R., Blits, B., Martin, K. R., Faissner, A., Ffrench-Constant, C. & Fawcett, J. W., Feb 2010, In : Brain. 133, p. 448-464 17 p.

    Research output: Contribution to journalArticle

  3. A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats.

    Mukhida, K., Hong, M., Miles, G. B., Phillips, T., Baghbaderani, B. A., McLeod, M., Kobayashi, N., Sen, A., Behie, L. A., Brownstone, R. M. & Mendez, I., 2008, In : Brain. 131, p. 2106-2126

    Research output: Contribution to journalArticle

  4. The neurology of disgust

    Sprengelmeyer, R. H., Jul 2007, In : Brain. 130, 7, p. 1715-1717 3 p.

    Research output: Contribution to journalArticle

ID: 33875349

Top