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Annelid Distal-less/Dlx duplications reveal varied post-duplication fates

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Annelid Distal-less/Dlx duplications reveal varied post-duplication fates. / McDougall, Carmel; Korchagina, Natalia; Tobin, Johnathan; Ferrier, David Ellard Keith.

In: BMC Evolutionary Biology, Vol. 11, 16.08.2011, p. 241.

Research output: Contribution to journalArticle

Harvard

McDougall, C, Korchagina, N, Tobin, J & Ferrier, DEK 2011, 'Annelid Distal-less/Dlx duplications reveal varied post-duplication fates', BMC Evolutionary Biology, vol. 11, pp. 241. https://doi.org/10.1186/1471-2148-11-241

APA

McDougall, C., Korchagina, N., Tobin, J., & Ferrier, D. E. K. (2011). Annelid Distal-less/Dlx duplications reveal varied post-duplication fates. BMC Evolutionary Biology, 11, 241. https://doi.org/10.1186/1471-2148-11-241

Vancouver

McDougall C, Korchagina N, Tobin J, Ferrier DEK. Annelid Distal-less/Dlx duplications reveal varied post-duplication fates. BMC Evolutionary Biology. 2011 Aug 16;11:241. https://doi.org/10.1186/1471-2148-11-241

Author

McDougall, Carmel ; Korchagina, Natalia ; Tobin, Johnathan ; Ferrier, David Ellard Keith. / Annelid Distal-less/Dlx duplications reveal varied post-duplication fates. In: BMC Evolutionary Biology. 2011 ; Vol. 11. pp. 241.

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@article{fc9f2495f5174a77816ae8a6282bee4c,
title = "Annelid Distal-less/Dlx duplications reveal varied post-duplication fates",
abstract = "Background:Dlx (Distal-less) genes have various developmental roles and are widespread throughout the animal kingdom, usually occurring as single copy genes in non-chordates and as multiple copies in most chordate genomes. While the genomic arrangement and function of these genes is well known in vertebrates and arthropods, information about Dlx genes in other organisms is scarce. We investigate the presence of Dlx genes in several annelid species and examine Dlx gene expression in the polychaete Pomatoceros lamarckii.Results:Two Dlx genes are present in P. lamarckii, Capitella teleta and Helobdella robusta. The C. teleta Dlx genes are closely linked in an inverted tail-to-tail orientation, reminiscent of the arrangement of vertebrate Dlx pairs, and gene conversion appears to have had a role in their evolution. The H. robusta Dlx genes, however, are not on the same genomic scaffold and display divergent sequences, while, if the P. lamarckii genes are linked in a tail-to-tail orientation they are a minimum of 41 kilobases apart and show no sign of gene conversion. No expression in P. lamarckii appendage development has been observed, which conflicts with the supposed conserved role of these genes in animal appendage development. These Dlx duplications do not appear to be annelid-wide, as the polychaete Platynereis dumerilii likely possesses only one Dlx gene.Conclusions:On the basis of the currently accepted annelid phylogeny, we hypothesise that one Dlx duplication occurred in the annelid lineage after the divergence of P. dumerilii from the other lineages and these duplicates then had varied evolutionary fates in different species. We also propose that the ancestral role of Dlx genes is not related to appendage development.",
author = "Carmel McDougall and Natalia Korchagina and Johnathan Tobin and Ferrier, {David Ellard Keith}",
note = "Additional files can be viewed at http://www.biomedcentral.com/1471-2148/11/241/additional/ {"}Work in the authors’ laboratory is supported by the BBSRC and the School of Biology, University of St Andrews{"}",
year = "2011",
month = "8",
day = "16",
doi = "10.1186/1471-2148-11-241",
language = "English",
volume = "11",
pages = "241",
journal = "BMC Evolutionary Biology",
issn = "1471-2148",
publisher = "BioMed Central",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Annelid Distal-less/Dlx duplications reveal varied post-duplication fates

AU - McDougall, Carmel

AU - Korchagina, Natalia

AU - Tobin, Johnathan

AU - Ferrier, David Ellard Keith

N1 - Additional files can be viewed at http://www.biomedcentral.com/1471-2148/11/241/additional/ "Work in the authors’ laboratory is supported by the BBSRC and the School of Biology, University of St Andrews"

PY - 2011/8/16

Y1 - 2011/8/16

N2 - Background:Dlx (Distal-less) genes have various developmental roles and are widespread throughout the animal kingdom, usually occurring as single copy genes in non-chordates and as multiple copies in most chordate genomes. While the genomic arrangement and function of these genes is well known in vertebrates and arthropods, information about Dlx genes in other organisms is scarce. We investigate the presence of Dlx genes in several annelid species and examine Dlx gene expression in the polychaete Pomatoceros lamarckii.Results:Two Dlx genes are present in P. lamarckii, Capitella teleta and Helobdella robusta. The C. teleta Dlx genes are closely linked in an inverted tail-to-tail orientation, reminiscent of the arrangement of vertebrate Dlx pairs, and gene conversion appears to have had a role in their evolution. The H. robusta Dlx genes, however, are not on the same genomic scaffold and display divergent sequences, while, if the P. lamarckii genes are linked in a tail-to-tail orientation they are a minimum of 41 kilobases apart and show no sign of gene conversion. No expression in P. lamarckii appendage development has been observed, which conflicts with the supposed conserved role of these genes in animal appendage development. These Dlx duplications do not appear to be annelid-wide, as the polychaete Platynereis dumerilii likely possesses only one Dlx gene.Conclusions:On the basis of the currently accepted annelid phylogeny, we hypothesise that one Dlx duplication occurred in the annelid lineage after the divergence of P. dumerilii from the other lineages and these duplicates then had varied evolutionary fates in different species. We also propose that the ancestral role of Dlx genes is not related to appendage development.

AB - Background:Dlx (Distal-less) genes have various developmental roles and are widespread throughout the animal kingdom, usually occurring as single copy genes in non-chordates and as multiple copies in most chordate genomes. While the genomic arrangement and function of these genes is well known in vertebrates and arthropods, information about Dlx genes in other organisms is scarce. We investigate the presence of Dlx genes in several annelid species and examine Dlx gene expression in the polychaete Pomatoceros lamarckii.Results:Two Dlx genes are present in P. lamarckii, Capitella teleta and Helobdella robusta. The C. teleta Dlx genes are closely linked in an inverted tail-to-tail orientation, reminiscent of the arrangement of vertebrate Dlx pairs, and gene conversion appears to have had a role in their evolution. The H. robusta Dlx genes, however, are not on the same genomic scaffold and display divergent sequences, while, if the P. lamarckii genes are linked in a tail-to-tail orientation they are a minimum of 41 kilobases apart and show no sign of gene conversion. No expression in P. lamarckii appendage development has been observed, which conflicts with the supposed conserved role of these genes in animal appendage development. These Dlx duplications do not appear to be annelid-wide, as the polychaete Platynereis dumerilii likely possesses only one Dlx gene.Conclusions:On the basis of the currently accepted annelid phylogeny, we hypothesise that one Dlx duplication occurred in the annelid lineage after the divergence of P. dumerilii from the other lineages and these duplicates then had varied evolutionary fates in different species. We also propose that the ancestral role of Dlx genes is not related to appendage development.

U2 - 10.1186/1471-2148-11-241

DO - 10.1186/1471-2148-11-241

M3 - Article

VL - 11

SP - 241

JO - BMC Evolutionary Biology

JF - BMC Evolutionary Biology

SN - 1471-2148

ER -

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