Skip to content

Research at St Andrews

Anti-Müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations

Research output: Contribution to journalArticlepeer-review

Author(s)

K-A Phillips, I M Collins, R L Milne, S A McLachlan, M Friedlander, M Hickey, C Stern, J L Hopper, R Fisher, G Kannemeyer, S Picken, C D Smith, Thomas William Kelsey, R A Anderson

School/Research organisations

Abstract

Study question: Do women with BRCA1 and BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-müllerian hormone (AMH) concentration? Summary answer: Women with a germline mutation in BRCA1 have reduced ovarian reserve as measured by AMH. What is known already: The DNA repair enzymes encoded by BRCA1 and BRCA2 are implicated in reproductive aging. Circulating AMH is a biomarker of ovarian reserve and hence reproductive lifespan. Study design, size, duration: Cross-sectional study of AMH concentrations of 693 women at the time of enrolment into the Kathleen Cuningham Foundation Consortium for research into Familial Breast Cancer (kConFab) cohort study (recruitment from 19/08/1997 until 18/9/2012). AMH was measured on stored plasma samples between November 2014 and January 2015 using an electrochemiluminescence immunoassay platform. Participants/materials, setting, methods: Eligible women were from families segregating BRCA1 or BRCA2 mutations and had known mutation status. Participants were aged 25 to 45 years, had no personal history of cancer, retained both ovaries and were not pregnant or breastfeeding at the time of plasma storage. Circulating AMH was measured for 172 carriers and 216 non-carriers from families carrying BRCA1 mutations, and 147 carriers and 158 non-carriers from families carrying BRCA2 mutations. Associations between plasma AMH concentration and carrier status were tested by linear regression, adjusted for age at plasma storage, oral contraceptive use, body mass index and cigarette smoking. Main results and the role of chance: Mean AMH concentration was negatively associated with age (P < 0.001). Mutation carriers were younger at blood draw than non-carriers (P ≤ 0.031). BRCA1 mutation carriers had, on average, 25% (95% CI: 5% - 41%, P = 0.02) lower AMH concentrations than non-carriers and were more likely to have AMH concentrations in the lowest quartile for age (OR 1.84, 95% CI: 1.11-303, P=0.02). There was no evidence of an association between AMH concentration and BRCA2 mutation status (P = 0.94). Limitations, reasons for caution: The clinical implications of the lower AMH concentrations seen in BRCA1 mutation carriers cannot be assessed by this study design. Wider implications of the findings: Women with a germline mutation in BRCA1 may have reduced ovarian reserve. This is consistent with other smaller studies in the literature and has potential implications for fertility and reproductive lifespan. 
Close

Details

Original languageEnglish
Pages (from-to)1126-1132
Number of pages7
JournalHuman Reproduction
Volume31
Issue number5
Early online date19 Apr 2016
DOIs
Publication statusPublished - May 2016

    Research areas

  • BRCA1, BRCA2, Anit-Müllerian hormone, Ovarian reserve, Fertility , DNA repair, Reproduction

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Diagnostic and predictive accuracy of anti-Mullerian hormone for ovarian function after chemotherapy in premenopausal women with early breast cancer

    Anderson, R. A., Kelsey, T., Perdix, A., Olympios, N., Duhamel, O., Lambertini, M. & Clatot, F., 8 Jan 2022, (E-pub ahead of print) In: Breast Cancer Research and Treatment. First Online, 10 p.

    Research output: Contribution to journalArticlepeer-review

  2. Ovarian function and fertility preservation for young people treated for cancer

    Caprioli, S., Kelsey, T. & Wallace, W. H. B., 1 Jan 2022, Female and male fertility preservation. Grynberg, M. & Patrizio, P. (eds.). Cham: Springer, p. 35-45

    Research output: Chapter in Book/Report/Conference proceedingChapter

  3. Changes in circulating kisspeptin levels during each trimester in women with antenatal complications

    Abbara, A., Al-Memar, M., Phylactou, M., Daniels, E., Patel, B., Chia Eng, P., Nadir, R., Izzi-Engbeaya, C., Clarke, S., Millis, E., Hunjan, T., Pacuszka, E., Yang, L., Bech, P., Tan, T., Comninos, A., Kelsey, T., Kyriacou, C., Fourie, H., Bourne, T. & 1 others, Dhillo, W., Jan 2022, In: Journal of Clinical Endocrinology & Metabolism. 107, 1, p. e71–e83 13 p., dgab617.

    Research output: Contribution to journalArticlepeer-review

  4. Family size and duration of fertility in female cancer survivors: a population based analysis

    Anderson, R. A., Kelsey, T., Morrison, D. S. & Wallace, W. H. B., 18 Dec 2021, (E-pub ahead of print) In: Fertility and Sterility. In press, 8 p.

    Research output: Contribution to journalArticlepeer-review

  5. Repurposing “old” blood tests to replace costly interim analysis/imaging of Hodgkin lymphoma in low and middle-income settings

    Geel, J., Kelsey, T., Hramyka, A., Myezo, K., Hendricks, M., Ngcana, T., Omar, F., Goga, Y., Neethling, B., Netshituni, V., van Zyl, A., Madzhia, E., Mathew, R., Ballot, D. & Metzger, M., 18 Oct 2021, p. PV0473 / #1372.

    Research output: Contribution to conferenceAbstractpeer-review

Related by journal

  1. Long-term follow up to assess criteria for ovarian tissue cryopreservation for fertility preservation in young women and girls with cancer

    Howie, R., Duffin, K., Kelsey, T., Wallace, W. H. B. & Anderson, R. A., Jul 2021, In: Human Reproduction. 36, p. 98-98 1 p.

    Research output: Contribution to journalAbstractpeer-review

  2. The impact of cancer on subsequent chance of pregnancy: a population-based analysis

    Anderson, R. A., Brewster, D. H., Wood, R., Nowell, S., Fischbacher, C., Kelsey, T. W. & Wallace, W. H. B., Jul 2018, In: Human Reproduction. 33, 7, p. 1281-1290 10 p.

    Research output: Contribution to journalArticlepeer-review

  3. Non-growing follicle density is increased following adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy in the adult human ovary

    McLaughlin, M., Kelsey, T. W., Wallace, W. H. B., Anderson, R. A. & Telfer, E. E., Jan 2017, In: Human Reproduction. 32, 1, p. 165-174

    Research output: Contribution to journalArticlepeer-review

  4. The relation between variation in size of the primordial follicle pool and menopause: a cohort comparison for observed and predicted distribution of age at menopause

    Depmann, M., Faddy, M. J., van der Schouw, Y. T., Broer, S. L., Kelsey, T. W., Nelson, S. M. & Broekmans, F. J. M., Jun 2015, In: Human Reproduction. 30, p. 408-408 1 p.

    Research output: Contribution to journalAbstractpeer-review

ID: 239828466

Top