Skip to content

Research at St Andrews

Are in vitro and in silico approaches used appropriately for animal-based major depressive disorder research?

Research output: Contribution to journalArticlepeer-review

Author(s)

Constança Carvalho, Susana A. M. Varela, Tiago A. Marques, Andrew Knight, Luís Vicente

School/Research organisations

Abstract

The current paradigm for biomedical research and drug testing postulates that in vitro and in silico data inform animal studies that will subsequently inform human studies. Recent evidence points out that animal studies have made a poor contribution to current knowledge of Major Depressive Disorder, whereas the contribution of in vitro and in silico studies to animal studies- within this research area- is yet to be properly quantified. This quantification is important since biomedical research and drug discovery and development includes two steps of knowledge transferability and we need to evaluate the effectiveness of both in order to properly implement 3R principles (Replacement, Reduction and Refinement). Here, we used the citation tracking facility within Web of Science to locate citations of original research papers on in vitro and in silico related to MDD published identified in PubMed by relevant search terms. 67 publications describing target papers were located. Both in vitro and in silico papers are more cited by human medical papers than by animal papers. The results suggest that, at least concerning MDD research, the current two steps of knowledge transferability are not being followed, indicating a poor compliance with the 3R principles.
Close

Details

Original languageEnglish
Article numbere0233954
Number of pages6
JournalPLoS ONE
Volume15
Issue number6
DOIs
Publication statusPublished - 24 Jun 2020

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Allometric relationships to assess ontogenetic adaptative changes in three NE Atlantic commercial sea cucumbers (Echinodermata, Holothuroidea)

    Azevedo e Silva, F., Brito, A. C., Simões, T., Pombo, A., Marques, T. A., Rocha, C., Sousa, J., Venâncio, E. & Félix, P. M., 29 Mar 2021, In: Aquatic Ecology.

    Research output: Contribution to journalArticlepeer-review

  2. Trends in cetacean research in the Eastern North Atlantic

    Cartagena-Matos, B., Lugué, K., Fonseca, P., Marques, T. A., Prieto, R. & Alves, F., 17 Feb 2021, In: Mammal Review. 18 p.

    Research output: Contribution to journalReview articlepeer-review

  3. Latitudinal variation in arrival and breeding phenology of the pied flycatcher Ficedula hypoleuca using large-scale citizen science data

    Nicolau, P. G., Burgess, M. D., Marques, T. A., Baillie, S. R., Moran, N. J., Leech, D. I. & Johnston, A., 12 Feb 2021, In: Journal of Avian Biology. 52, 2

    Research output: Contribution to journalArticlepeer-review

  4. COVID-19: nothing is normal in this pandemic

    Gonçalves, L., Turkman, M. A. A., Geraldes, C., Marques, T. A. & Sousa, L., 20 Jan 2021, In: Journal of Epidemiology and Global Health. In Press

    Research output: Contribution to journalArticlepeer-review

  5. Deep-diving beaked whales dive together but forage apart

    Alcázar-Treviño, J., Johnson, M., Arranz, P., Warren, V. E., Pérez-González, C. J., Marques, T., Madsen, P. T. & Aguilar de Soto, N., 13 Jan 2021, In: Proceedings of the Royal Society B: Biological Sciences. 288, 1942, 20201905.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. PLoS ONE (Journal)

    Joanna Louise Kershaw (Reviewer)

    18 Mar 2019

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  2. PLoS One (Journal)

    Paula Jean Miles (Member of editorial board)

    2019

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  3. PLoS ONE (Journal)

    Catharine Penelope Cross (Member of editorial board)

    1 Sep 2018 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  4. PLoS ONE (Journal)

    Will Cresswell (Reviewer)

    23 May 2018

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  5. PLoS ONE (Journal)

    Barbara Dritschel (Member of editorial board)

    May 2018 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

Related by journal

  1. Ecosystem engineers drive differing microbial community composition in intertidal estuarine sediments

    Wyness, A. J., Fortune, I., Blight, A. J., Browne, P., Hartley, M., Holden, M. & Paterson, D. M., 19 Feb 2021, In: PLoS ONE. 16, 2, 20 p., e0240952.

    Research output: Contribution to journalArticlepeer-review

  2. Hierarchical modelling of factors associated with the practice and perpetuation of female genital mutilation in the next generation of women in Africa

    Fagbamigbe, A. F., Morhason-Bello, I. O., Kareem, Y. O. & Idemudia, E. S., 23 Apr 2021, In: PLoS ONE. 16, 4, e0250411.

    Research output: Contribution to journalArticlepeer-review

  3. Performance evaluation of survival regression models in analysing Swedish dental implant complication data with frailty

    Fagbamigbe, A. F., Karlsson, K., Derks, J. & Petzold, M., 7 Jan 2021, In: PLoS ONE. 16, 1, 16 p., e0245111.

    Research output: Contribution to journalArticlepeer-review

  4. Young children share more under time pressure than after a delay

    Ploetner, M., Hepach, R., Over, H., Carpenter, M. & Tomasello, M., 16 Mar 2021, In: PLoS One. 16, 3, 10 p., e0248121.

    Research output: Contribution to journalArticlepeer-review

ID: 268707070

Top