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Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes

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Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes. / Zaric, Bozidarka L.; Radovanovic, Jelena N.; Gluvic, Zoran; Stewart, Alan J.; Essak, Magbubah; Motwalli, Olaa; Gojobori, Takashi; Isenovic, Esma R.

In: Frontiers in Immunology, Vol. 11, 551758, 28.09.2020.

Research output: Contribution to journalReview article

Harvard

Zaric, BL, Radovanovic, JN, Gluvic, Z, Stewart, AJ, Essak, M, Motwalli, O, Gojobori, T & Isenovic, ER 2020, 'Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes', Frontiers in Immunology, vol. 11, 551758. https://doi.org/10.3389/fimmu.2020.551758

APA

Zaric, B. L., Radovanovic, J. N., Gluvic, Z., Stewart, A. J., Essak, M., Motwalli, O., Gojobori, T., & Isenovic, E. R. (2020). Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes. Frontiers in Immunology, 11, [551758]. https://doi.org/10.3389/fimmu.2020.551758

Vancouver

Zaric BL, Radovanovic JN, Gluvic Z, Stewart AJ, Essak M, Motwalli O et al. Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes. Frontiers in Immunology. 2020 Sep 28;11. 551758. https://doi.org/10.3389/fimmu.2020.551758

Author

Zaric, Bozidarka L. ; Radovanovic, Jelena N. ; Gluvic, Zoran ; Stewart, Alan J. ; Essak, Magbubah ; Motwalli, Olaa ; Gojobori, Takashi ; Isenovic, Esma R. / Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes. In: Frontiers in Immunology. 2020 ; Vol. 11.

Bibtex - Download

@article{45fe0ccba30c48df97fa6d8e5338deff,
title = "Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes",
abstract = "Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases (1 and 2) are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.",
keywords = "Amino acids, Atherosclerosis, Metabolism, Branched-chain amino acids, Arginine, Tryptophan",
author = "Zaric, {Bozidarka L.} and Radovanovic, {Jelena N.} and Zoran Gluvic and Stewart, {Alan J.} and Magbubah Essak and Olaa Motwalli and Takashi Gojobori and Isenovic, {Esma R.}",
note = "This work is part of the collaboration between the Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia, and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Saudi Arabia. The research was funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia and by the KAUST grant OSR#4129 (E.R.I I TG). T.G. was supported by the KAUST Base Research Funds BAS/1/1059-01-01, respectively, while M.E. was supported by the KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.",
year = "2020",
month = sep,
day = "28",
doi = "10.3389/fimmu.2020.551758",
language = "English",
volume = "11",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S. A.",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes

AU - Zaric, Bozidarka L.

AU - Radovanovic, Jelena N.

AU - Gluvic, Zoran

AU - Stewart, Alan J.

AU - Essak, Magbubah

AU - Motwalli, Olaa

AU - Gojobori, Takashi

AU - Isenovic, Esma R.

N1 - This work is part of the collaboration between the Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia, and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Saudi Arabia. The research was funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia and by the KAUST grant OSR#4129 (E.R.I I TG). T.G. was supported by the KAUST Base Research Funds BAS/1/1059-01-01, respectively, while M.E. was supported by the KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.

PY - 2020/9/28

Y1 - 2020/9/28

N2 - Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases (1 and 2) are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.

AB - Cardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases (1 and 2) are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.

KW - Amino acids

KW - Atherosclerosis

KW - Metabolism

KW - Branched-chain amino acids

KW - Arginine

KW - Tryptophan

U2 - 10.3389/fimmu.2020.551758

DO - 10.3389/fimmu.2020.551758

M3 - Review article

VL - 11

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 551758

ER -

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