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Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine

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Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine. / Wilson, David I. G.; MacLaren, Duncan A. A.; Winn, Philip.

In: European Journal of Neuroscience, Vol. 30, No. 3, 08.2009, p. 504-513.

Research output: Contribution to journalArticle

Harvard

Wilson, DIG, MacLaren, DAA & Winn, P 2009, 'Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine', European Journal of Neuroscience, vol. 30, no. 3, pp. 504-513. https://doi.org/10.1111/j.1460-9568.2009.06836.x

APA

Wilson, D. I. G., MacLaren, D. A. A., & Winn, P. (2009). Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine. European Journal of Neuroscience, 30(3), 504-513. https://doi.org/10.1111/j.1460-9568.2009.06836.x

Vancouver

Wilson DIG, MacLaren DAA, Winn P. Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine. European Journal of Neuroscience. 2009 Aug;30(3):504-513. https://doi.org/10.1111/j.1460-9568.2009.06836.x

Author

Wilson, David I. G. ; MacLaren, Duncan A. A. ; Winn, Philip. / Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine. In: European Journal of Neuroscience. 2009 ; Vol. 30, No. 3. pp. 504-513.

Bibtex - Download

@article{052b337dbc4b482d98d0c278e75bc14d,
title = "Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine",
abstract = "The pedunculopontine tegmental nucleus (PPTg) is in a key position to participate in operant reinforcement via its connections with the corticostriatal architecture and the medial reticular formation. Indeed, previous work has demonstrated that rats bearing lesions of the whole PPTg are impaired when learning to make two bar presses for amphetamine reinforcement. Anterior and posterior portions of the PPTg make different anatomical connections, including preferential projections by the anterior PPTg to substantia nigra pars compacta dopamine neurons and by the posterior PPTg to ventral tegmental area dopamine neurons. We wanted to assess the effects of anterior and posterior PPTg ibotenate lesions on rats learning simple and more complex schedules of natural reinforcement. We trained rats with lesions to the anterior PPTg (n = 11) and the posterior PPTg (n = 5) [and appropriate controls (n = 15)] to bar press for food on a variety of fixed-ratio and variable-ratio reinforcement schedules and then during extinction. We found that posterior PPTg-lesioned rats bar pressed at lower rates, were slower to learn to bar press, and often had deficits characteristic of impaired learning and/or motivation. In contrast, anterior PPTg-lesioned rats learned to bar press for reinforcement at normal rates. However, they made errors of perseveration and anticipation throughout many schedules, and pressed at a higher rate than controls during extinction, deficits best characterized as reflecting disorganized response control. Together, these data suggest that the anterior PPTg and posterior PPTg (and their related circuits) contribute differently to reinforcement learning, incentive motivation, and response control, processes that are considered to malfunction in drug addiction.",
keywords = "dopamine, learning, motivation, PPTg, reinforcement, reward, TEGMENTAL NUCLEUS, EXCITOTOXIC LESIONS, D-AMPHETAMINE, SUCROSE REWARD, REINFORCEMENT, DOPAMINE, LOCOMOTION, DISSOCIATION, NICOTINE, STRIATUM",
author = "Wilson, {David I. G.} and MacLaren, {Duncan A. A.} and Philip Winn",
year = "2009",
month = "8",
doi = "10.1111/j.1460-9568.2009.06836.x",
language = "English",
volume = "30",
pages = "504--513",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley",
number = "3",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Bar pressing for food: differential consequences of lesions to the anterior versus posterior pedunculopontine

AU - Wilson, David I. G.

AU - MacLaren, Duncan A. A.

AU - Winn, Philip

PY - 2009/8

Y1 - 2009/8

N2 - The pedunculopontine tegmental nucleus (PPTg) is in a key position to participate in operant reinforcement via its connections with the corticostriatal architecture and the medial reticular formation. Indeed, previous work has demonstrated that rats bearing lesions of the whole PPTg are impaired when learning to make two bar presses for amphetamine reinforcement. Anterior and posterior portions of the PPTg make different anatomical connections, including preferential projections by the anterior PPTg to substantia nigra pars compacta dopamine neurons and by the posterior PPTg to ventral tegmental area dopamine neurons. We wanted to assess the effects of anterior and posterior PPTg ibotenate lesions on rats learning simple and more complex schedules of natural reinforcement. We trained rats with lesions to the anterior PPTg (n = 11) and the posterior PPTg (n = 5) [and appropriate controls (n = 15)] to bar press for food on a variety of fixed-ratio and variable-ratio reinforcement schedules and then during extinction. We found that posterior PPTg-lesioned rats bar pressed at lower rates, were slower to learn to bar press, and often had deficits characteristic of impaired learning and/or motivation. In contrast, anterior PPTg-lesioned rats learned to bar press for reinforcement at normal rates. However, they made errors of perseveration and anticipation throughout many schedules, and pressed at a higher rate than controls during extinction, deficits best characterized as reflecting disorganized response control. Together, these data suggest that the anterior PPTg and posterior PPTg (and their related circuits) contribute differently to reinforcement learning, incentive motivation, and response control, processes that are considered to malfunction in drug addiction.

AB - The pedunculopontine tegmental nucleus (PPTg) is in a key position to participate in operant reinforcement via its connections with the corticostriatal architecture and the medial reticular formation. Indeed, previous work has demonstrated that rats bearing lesions of the whole PPTg are impaired when learning to make two bar presses for amphetamine reinforcement. Anterior and posterior portions of the PPTg make different anatomical connections, including preferential projections by the anterior PPTg to substantia nigra pars compacta dopamine neurons and by the posterior PPTg to ventral tegmental area dopamine neurons. We wanted to assess the effects of anterior and posterior PPTg ibotenate lesions on rats learning simple and more complex schedules of natural reinforcement. We trained rats with lesions to the anterior PPTg (n = 11) and the posterior PPTg (n = 5) [and appropriate controls (n = 15)] to bar press for food on a variety of fixed-ratio and variable-ratio reinforcement schedules and then during extinction. We found that posterior PPTg-lesioned rats bar pressed at lower rates, were slower to learn to bar press, and often had deficits characteristic of impaired learning and/or motivation. In contrast, anterior PPTg-lesioned rats learned to bar press for reinforcement at normal rates. However, they made errors of perseveration and anticipation throughout many schedules, and pressed at a higher rate than controls during extinction, deficits best characterized as reflecting disorganized response control. Together, these data suggest that the anterior PPTg and posterior PPTg (and their related circuits) contribute differently to reinforcement learning, incentive motivation, and response control, processes that are considered to malfunction in drug addiction.

KW - dopamine

KW - learning

KW - motivation

KW - PPTg

KW - reinforcement

KW - reward

KW - TEGMENTAL NUCLEUS

KW - EXCITOTOXIC LESIONS

KW - D-AMPHETAMINE

KW - SUCROSE REWARD

KW - REINFORCEMENT

KW - DOPAMINE

KW - LOCOMOTION

KW - DISSOCIATION

KW - NICOTINE

KW - STRIATUM

UR - http://www.scopus.com/inward/record.url?scp=68249132611&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2009.06836.x

DO - 10.1111/j.1460-9568.2009.06836.x

M3 - Article

VL - 30

SP - 504

EP - 513

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 3

ER -

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