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Breed differences in dog cognition associated with brain-expressed genes and neurological functions

Research output: Contribution to journalArticlepeer-review

DOI

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Breed differences in dog cognition associated with brain-expressed genes and neurological functions. / Gnanadesiken, Gitanjali E.; Hare, Brian; Snyder-Mackler, Noah; Call, Josep; Kaminski, Juliane; Miklósi, Ádám; MacLean, Evan L.

In: Integrative and Comparative Biology, Vol. In press, icaa112, 29.07.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Gnanadesiken, GE, Hare, B, Snyder-Mackler, N, Call, J, Kaminski, J, Miklósi, Á & MacLean, EL 2020, 'Breed differences in dog cognition associated with brain-expressed genes and neurological functions', Integrative and Comparative Biology, vol. In press, icaa112. https://doi.org/10.1093/icb/icaa112

APA

Gnanadesiken, G. E., Hare, B., Snyder-Mackler, N., Call, J., Kaminski, J., Miklósi, Á., & MacLean, E. L. (2020). Breed differences in dog cognition associated with brain-expressed genes and neurological functions. Integrative and Comparative Biology, In press, [icaa112]. https://doi.org/10.1093/icb/icaa112

Vancouver

Gnanadesiken GE, Hare B, Snyder-Mackler N, Call J, Kaminski J, Miklósi Á et al. Breed differences in dog cognition associated with brain-expressed genes and neurological functions. Integrative and Comparative Biology. 2020 Jul 29;In press. icaa112. https://doi.org/10.1093/icb/icaa112

Author

Gnanadesiken, Gitanjali E. ; Hare, Brian ; Snyder-Mackler, Noah ; Call, Josep ; Kaminski, Juliane ; Miklósi, Ádám ; MacLean, Evan L. / Breed differences in dog cognition associated with brain-expressed genes and neurological functions. In: Integrative and Comparative Biology. 2020 ; Vol. In press.

Bibtex - Download

@article{d74c56a8ea364dd8bf4239a6689053ae,
title = "Breed differences in dog cognition associated with brain-expressed genes and neurological functions",
abstract = "Given their remarkable phenotypic diversity, dogs present a unique opportunity for investigating the genetic bases of cognitive and behavioral traits. Our previous work demonstrated that genetic relatedness among breeds accounts for a substantial portion of variation in dog cognition. Here, we investigated the genetic architecture of breed differences in cognition, seeking to identify genes that contribute to variation in cognitive phenotypes. To do so, we combined cognitive data from the citizen science project Dognition.com with published breed-average genetic polymorphism data, resulting in a dataset of 1654 individuals with cognitive phenotypes representing 49 breeds. We conducted a breed-average genome-wide association study to identify specific polymorphisms associated with breed differences in inhibitory control, communication, memory, and physical reasoning. We found five single nucleotide polymorphisms (SNPs) that reached genome-wide significance after Bonferroni correction, located in EML1, OR52E2, HS3ST5, a U6 spliceosomal RNA, and a long non-coding RNA. When we combined results across multiple SNPs within the same gene, we identified 188 genes implicated in breed differences in cognition. This gene set included more genes than expected by chance that were 1) differentially expressed in brain tissue and 2) involved in nervous system functions including peripheral nervous system development, Wnt signaling, presynapse assembly, and synaptic vesicle exocytosis. These results advance our understanding of the genetic underpinnings of complex cognitive phenotypes and identify specific genetic variants for further research.",
author = "Gnanadesiken, {Gitanjali E.} and Brian Hare and Noah Snyder-Mackler and Josep Call and Juliane Kaminski and {\'A}d{\'a}m Mikl{\'o}si and MacLean, {Evan L.}",
note = "G.E.G. was funded by the NSF Graduate Research Fellowship Program (DGE-1746060). B.H. was supported in part by the National Institutes of Health (Grant 1R01HD097732-01). {\'A}.M. received funding from MTA-ELTE Comparative Ethology Research Group (MTA01 031) and the National Brain Research Program (2017-1.2.1-NKP-2017-00002).",
year = "2020",
month = jul,
day = "29",
doi = "10.1093/icb/icaa112",
language = "English",
volume = "In press",
journal = "Integrative and Comparative Biology",
issn = "1540-7063",
publisher = "Oxford University Press",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Breed differences in dog cognition associated with brain-expressed genes and neurological functions

AU - Gnanadesiken, Gitanjali E.

AU - Hare, Brian

AU - Snyder-Mackler, Noah

AU - Call, Josep

AU - Kaminski, Juliane

AU - Miklósi, Ádám

AU - MacLean, Evan L.

N1 - G.E.G. was funded by the NSF Graduate Research Fellowship Program (DGE-1746060). B.H. was supported in part by the National Institutes of Health (Grant 1R01HD097732-01). Á.M. received funding from MTA-ELTE Comparative Ethology Research Group (MTA01 031) and the National Brain Research Program (2017-1.2.1-NKP-2017-00002).

PY - 2020/7/29

Y1 - 2020/7/29

N2 - Given their remarkable phenotypic diversity, dogs present a unique opportunity for investigating the genetic bases of cognitive and behavioral traits. Our previous work demonstrated that genetic relatedness among breeds accounts for a substantial portion of variation in dog cognition. Here, we investigated the genetic architecture of breed differences in cognition, seeking to identify genes that contribute to variation in cognitive phenotypes. To do so, we combined cognitive data from the citizen science project Dognition.com with published breed-average genetic polymorphism data, resulting in a dataset of 1654 individuals with cognitive phenotypes representing 49 breeds. We conducted a breed-average genome-wide association study to identify specific polymorphisms associated with breed differences in inhibitory control, communication, memory, and physical reasoning. We found five single nucleotide polymorphisms (SNPs) that reached genome-wide significance after Bonferroni correction, located in EML1, OR52E2, HS3ST5, a U6 spliceosomal RNA, and a long non-coding RNA. When we combined results across multiple SNPs within the same gene, we identified 188 genes implicated in breed differences in cognition. This gene set included more genes than expected by chance that were 1) differentially expressed in brain tissue and 2) involved in nervous system functions including peripheral nervous system development, Wnt signaling, presynapse assembly, and synaptic vesicle exocytosis. These results advance our understanding of the genetic underpinnings of complex cognitive phenotypes and identify specific genetic variants for further research.

AB - Given their remarkable phenotypic diversity, dogs present a unique opportunity for investigating the genetic bases of cognitive and behavioral traits. Our previous work demonstrated that genetic relatedness among breeds accounts for a substantial portion of variation in dog cognition. Here, we investigated the genetic architecture of breed differences in cognition, seeking to identify genes that contribute to variation in cognitive phenotypes. To do so, we combined cognitive data from the citizen science project Dognition.com with published breed-average genetic polymorphism data, resulting in a dataset of 1654 individuals with cognitive phenotypes representing 49 breeds. We conducted a breed-average genome-wide association study to identify specific polymorphisms associated with breed differences in inhibitory control, communication, memory, and physical reasoning. We found five single nucleotide polymorphisms (SNPs) that reached genome-wide significance after Bonferroni correction, located in EML1, OR52E2, HS3ST5, a U6 spliceosomal RNA, and a long non-coding RNA. When we combined results across multiple SNPs within the same gene, we identified 188 genes implicated in breed differences in cognition. This gene set included more genes than expected by chance that were 1) differentially expressed in brain tissue and 2) involved in nervous system functions including peripheral nervous system development, Wnt signaling, presynapse assembly, and synaptic vesicle exocytosis. These results advance our understanding of the genetic underpinnings of complex cognitive phenotypes and identify specific genetic variants for further research.

U2 - 10.1093/icb/icaa112

DO - 10.1093/icb/icaa112

M3 - Article

VL - In press

JO - Integrative and Comparative Biology

JF - Integrative and Comparative Biology

SN - 1540-7063

M1 - icaa112

ER -

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