Skip to content

Research at St Andrews

Bright and early: inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function

Research output: Contribution to journalReview articlepeer-review

DOI

Open Access permissions

Open

Abstract

The human cytomegalovirus (HCMV), one of eight human herpesviruses, establishes lifelong latent infections in most people worldwide. Primary or reactivated HCMV infections cause severe disease in immunosuppressed patients and congenital defects in children. There is no vaccine for HCMV, and the currently approved antivirals come with major limitations. Most approved HCMV antivirals target late molecular processes in the viral replication cycle including DNA replication and packaging. “Bright and early” events in HCMV infection have not been exploited for systemic prevention or treatment of disease. Initiation of HCMV replication depends on transcription from the viral major immediate-early (IE) gene. Alternative transcripts produced from this gene give rise to the IE1 and IE2 families of viral proteins, which localize to the host cell nucleus.The IE1 and IE2 proteins are believed to control all subsequent early and late events in HCMV replication, including reactivation from latency, in part by antagonizing intrinsic and innate immune responses. Here we provide an update on the regulation of major IE gene expression and the functions of IE1 and IE2 proteins. We will relate this insight to experimental approaches that target IE gene expression or protein function via molecular gene silencing and editing or small chemical inhibitors.
Close

Details

Original languageEnglish
Article number110
Number of pages41
JournalViruses
Volume12
Issue number1
DOIs
Publication statusPublished - 16 Jan 2020

    Research areas

  • Herpesvirus, Cytomegalovirus, Immediate-early, IE1, IE2, Antiviral, Ribozyme, RNA interference, CRISPR/Cas, Small molecule

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Modular cell-based platform for high throughput identification of compounds that inhibit a viral interferon antagonist of choice

    Vasou, A., Paulus, C., Narloch, J., Gage, Z. O., Rameix-Welti, M-A., Eléouët, J-F., Nevels, M., Randall, R. E. & Adamson, C. S., Feb 2018, In: Antiviral Research. 150, p. 79-92

    Research output: Contribution to journalArticlepeer-review

  2. The quest for COVID-19 treatments

    Hilton, J. V. & Adamson, C. S., 1 Oct 2021, Microbiology Today, 48, 2, p. 82-85 4 p.

    Research output: Contribution to specialist publicationArticle

  3. Editorial: Cytomegalovirus pathogenesis and host interactions

    Poole, E. L. & Nevels, M. M., 7 Jul 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 5 p., 711551.

    Research output: Contribution to journalEditorialpeer-review

  4. Antiviral drug discovery: preparing for the next pandemic

    Adamson, C. S., Chibale, K., Goss, R., Jaspars, M., Newman, D. J. & Dorrington, R. A., 1 Feb 2021, (E-pub ahead of print) In: Chemical Society Reviews. Advance Article, 9 p.

    Research output: Contribution to journalReview articlepeer-review

  5. Evidence for tethering of human cytomegalovirus genomes to host chromosomes

    Mauch-Mücke, K., Schön, K., Paulus, C. & Nevels, M. M., 30 Sep 2020, In: Frontiers in Cellular and Infection Microbiology. 10, 11 p., 577428.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Isolation and identification of inter-species Enterovirus recombinant genomes

    Bentley, K., Tee, H. K., Pearson, A., Lowry, K., Waugh, S., Jones, S., Chan, Y. F. & Evans, D. J., 29 Nov 2021, In: Viruses. 13, 12, 17 p., 2390.

    Research output: Contribution to journalArticlepeer-review

  2. Does the zinc finger antiviral protein (ZAP) shape the evolution of herpesvirus genomes?

    Lin, Y-T., Chau, L-F., Coutts, H., Mahmoudi, M., Drampa, V., Lee, C-H., Brown, A., Hughes, D. J. & Grey, F., 17 Sep 2021, In: Viruses. 13, 9, 15 p., e1857.

    Research output: Contribution to journalReview articlepeer-review

  3. Human papillomavirus detection by whole-genome next-generation sequencing: importance of validation and quality assurance procedures

    Arroyo Mühr, L. S., Guerendiain, D., Cuschieri, K. & Sundström, K., 8 Jul 2021, In: Viruses. 13, 7, 18 p., 1323.

    Research output: Contribution to journalArticlepeer-review

  4. Potato virus Y emergence and evolution from the Andes of South America to become a major destructive pathogen of potato and other solanaceous crops worldwide

    Torrance, L. & Talianksy, M. E., 12 Dec 2020, In: Viruses. 12, 12, 14 p., 1430.

    Research output: Contribution to journalReview articlepeer-review

  5. Green bees: reverse genetic analysis of deformed wing virus transmission, replication, and tropism

    Gusachenko, O. N., Woodford, L., Balbirnie-Cumming, K., Campbell, E. M., Christie, C. R., Bowman, A. S. & Evans, D. J., 12 May 2020, In: Viruses. 12, 5, 17 p., 532.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Viruses (Journal)

    Catherine S Adamson (Editor)

    24 Apr 2020

    Activity: Publication peer-review and editorial work typesEditor of research journal

  2. Viruses (Journal)

    Catherine S Adamson (Guest editor)

    Feb 2019Jan 2020

    Activity: Publication peer-review and editorial work typesEditor of research journal

  3. Viruses (Journal)

    Joanna Louise Parish (Editor)

    2009 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

ID: 265462751

Top