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Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions

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Yohann J. G. Renault, Rosemary Lynch, Enrico Marelli, Sunil V. Sharma, Cristina Pubill Ulldemolins, Joshua Sharp, Christopher Cartmell, Paco Cárdenas, Rebecca J. M. Goss

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Abstract

Blending synthetic chemistry and biology is synthetically powerful. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halotryptophans in aqueous systems and demonstrate this methodology applicable to the modification of unprotected halotryptophans, simple tripeptides and the natural product barettin.
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Original languageEnglish
Number of pages4
JournalChemical Communications
VolumeAdvance Article
Early online date8 Oct 2019
DOIs
Publication statusE-pub ahead of print - 8 Oct 2019

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