Skip to content

Research at St Andrews

Cell proliferation dynamics in regeneration of the operculum head appendage in the annelid Pomatoceros lamarckii

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Abstract

Regeneration of lost or damaged appendages is a widespread and ecologically important ability in the animal kingdom, and also of great significance to developing regenerative medicine. The operculum of serpulid polychaetes is one among the many diverse appendages found in the lophotrochozoan superphylum, a clade hitherto understudied with respect to the mechanisms of appendage regeneration. In this study, we establish the normal time course of opercular regeneration in the serpulid Pomatoceros lamarckii and describe cell proliferation patterns in the regenerating opercular filament. The P. lamarckii operculum regenerates through a rapid and consistent series of morphogenetic events. Based on 5-bromo-2'-deoxyuridine (BrdU) labelling and anti-phosphohistone H3 immunohistochemistry, opercular regeneration appears to be a mixture of an early morphallactic stage and a later phase characterised by widespread proliferative activity within the opercular filament. Tracking residual pigmentation suggests that the distal part of the stump gives rise to the most distal structures of the operculum via morphallactic remodelling, whereas more proximal structures are derived from the proximal stump. Our work underscores the diversity of regenerative strategies employed by animals and introduces P. lamarckii as an emerging model of appendage regeneration.
Close

Details

Original languageEnglish
Pages (from-to)257-268
JournalJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
Volume322B
Issue number5
Early online date5 May 2014
DOIs
StatePublished - Jul 2014

    Research areas

  • morphallaxis, lophotrochozoan, BrdU, Phospohistone H3, polychaete

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Two more Posterior Hox genes and Hox cluster dispersal in echinoderms

    Szabó, R. & Ferrier, D. E. K. 27 Dec 2018 In : BMC Evolutionary Biology. 18, 13 p., 203

    Research output: Contribution to journalArticle

  2. Transcriptional regulation of the Ciona Gsx gene in the neural plate

    Hudson, C., Esposito, R., Palladino, A., Staiano, L., Ferrier, D., Faure, E., Lemaire, P., Yasuo, H. & Spagnuolo, A. 21 Dec 2018 In : Developmental Biology. In press

    Research output: Contribution to journalArticle

  3. Amphioxus functional genomics and the origins of vertebrate gene regulation

    Marletaz, F. , Firbas, P. , Maeso, I. , Tena, J. , Bogdanovic, O. , Perry, M. , Wyatt, C. , de la Calle-Mustienes, E. , Bertrand, S. , Burguera, D. , Acemel, R. , van Heeringen, S. , Naranjo, S. , Herrera-Ubeda, C. , Skvortsova, K. , Jimenez-Gancedo, S. , Aldea, D. , Marquez, Y. , Buono, L. , Kozmikova, I. & 41 others Permanyer, J., Louis, A., Albuixech-Crespo, B., Le Petillon, Y., Leon Florian, A., Subirana, L., Balwierz, P. J., Duckett, P., Farahani, E., Aury, J. M., Mangenot, S., Wincker, P., Albalat, R., Benito-Gutierrez, E., Canestro, C., Castro, F., D'Aniello, S., Ferrier, D. E. K., Huang, S., Laudet, V., Marais, G., Pontarotti, P., Schubert, M., Seitz, H., Somorjai, I. M. L., Takahashi, T., Mirabeau, O., Xu, A., Yu, J-K., Carninci, P., Martinez-Morales, J., Crollius, H., Kozmik, Z., Weirauch, M., Garcia-Fernandez, J., Lister, R., Lenhard, B., Holland, P., Escriva, H., Gomez-Skarmeta, J. L. & Irimia, M. 21 Nov 2018 In : Nature. 564, 7734, p. 64-70 29 p.

    Research output: Contribution to journalArticle

  4. Horizons in evolutionary genomics: an interview with David Ferrier

    Ferrier, D. E. K. 1 Nov 2018 In : BMC Biology. 16, 3 p., 124

    Research output: Contribution to journalArticle

  5. Genome biology: unconventional DNA repair in an extreme genome

    Ferrier, D. E. K. & Sogabe, S. 22 Oct 2018 In : Current Biology. 28, 20, p. R1208-R1210

    Research output: Contribution to journalReview article

Related by journal

  1. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (Journal)

    Ferrier, D. E. K. (Member of editorial board)
    20062017

    Activity: Publication peer-review and editorial workEditor of research journal

  2. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution (Journal)

    Ferrier, D. E. K. (Member of editorial board)
    2006 → …

    Activity: Publication peer-review and editorial workEditor of research journal

Related by journal

  1. EvoDevo and niche construction: building bridges

    Laland, K. N., Odling-Smee, F. J. & Gilbert, S. F. 15 Nov 2008 In : Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 310B, 7, p. 549-566 18 p.

    Research output: Contribution to journalArticle

  2. The amphioxus Hox cluster: characterization, comparative genomics, and evolution

    Amemiya, C. T., Prohaska, S. J., Hill-Force, A., Cook, A., Wasserscheid, J., Ferrier, D. E. K., Pascual-Anaya, J., Garcia-Fernandez, J., Dewar, K. & Stadler, P. F. 15 Jul 2008 In : Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 310B, 5, p. 465 - 477 13 p.

    Research output: Contribution to journalArticle

ID: 117073236