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Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation

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Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation. / Mamsen, Linn Salto; Charkiewicz, Karol; Anderson, Richard A.; Telfer, Evelyn E.; McLaughlin, Marie; Kelsey, Thomas W.; Kristensen, Stine G.; Gook, Debra A.; Ernst, Erik; Andersen, Claus Yding.

In: Fertility and Sterility, Vol. 111, No. 6, 06.2019, p. 1217-1225.e3.

Research output: Contribution to journalArticle

Harvard

Mamsen, LS, Charkiewicz, K, Anderson, RA, Telfer, EE, McLaughlin, M, Kelsey, TW, Kristensen, SG, Gook, DA, Ernst, E & Andersen, CY 2019, 'Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation', Fertility and Sterility, vol. 111, no. 6, pp. 1217-1225.e3. https://doi.org/10.1016/j.fertnstert.2019.02.003

APA

Mamsen, L. S., Charkiewicz, K., Anderson, R. A., Telfer, E. E., McLaughlin, M., Kelsey, T. W., ... Andersen, C. Y. (2019). Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation. Fertility and Sterility, 111(6), 1217-1225.e3. https://doi.org/10.1016/j.fertnstert.2019.02.003

Vancouver

Mamsen LS, Charkiewicz K, Anderson RA, Telfer EE, McLaughlin M, Kelsey TW et al. Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation. Fertility and Sterility. 2019 Jun;111(6):1217-1225.e3. https://doi.org/10.1016/j.fertnstert.2019.02.003

Author

Mamsen, Linn Salto ; Charkiewicz, Karol ; Anderson, Richard A. ; Telfer, Evelyn E. ; McLaughlin, Marie ; Kelsey, Thomas W. ; Kristensen, Stine G. ; Gook, Debra A. ; Ernst, Erik ; Andersen, Claus Yding. / Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation. In: Fertility and Sterility. 2019 ; Vol. 111, No. 6. pp. 1217-1225.e3.

Bibtex - Download

@article{883645904ad1462c8199e6d94489d162,
title = "Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation",
abstract = "Objective: To characterize ovarian follicles of girls and young women with Turner syndrome (TS) who underwent ovarian tissue cryopreservation (OTC).Design: Retrospective case-control study.Setting: University hospital.Patient(s): Fifteen girls and young women with TS aged 5-22 years at OTC were included, together with 42 control girls and young women aged 1-25 years who underwent OTC because of cancer.Intervention(s): None.Main Outcome Measure(s): Follicle density (follicles/mm(3)), morphology, and health were assessed in ovarian cortex biopsies from TS patients and compared with controls. Hormone concentrations were measured in serum and follicle fluids. Immature cumulus oocyte complexes were obtained and matured in vitro.Result(s): Follicles were found in 60{\%} of the biopsies (9 of 15) from TS ovaries. In 78{\%} of the ovaries (7 of 9) with follicles, the follicle density was within the 95{\%} confidence interval of the control group. There was a high rate of abnormal follicle morphology. Six follicle-specific proteins were expressed similarly in TS and control ovaries. However, apoptosis and zona pellucida protein expression were found to be abnormal in TS. Turner syndrome follicle fluid from small antral follicles had lower concentrations of estrogen and testosterone and higher concentrations of antimullerian hormone than controls. Thirty-one cumulus oocyte complexes were collected from one patient and cultured for 48 hours in vitro, resulting in five metaphase II oocytes (maturation rate 16{\%}, degeneration rate 19{\%}).Conclusion(s): The benefits of OTC may be limited to a highly selected group of TS mosaic patients in whom a sizeable pool of normal follicles is present at OTC. (C) 2019 by American Society for Reproductive Medicine.",
keywords = "Turner syndrome, Follicle density, Ovarian tissue cryopreservation",
author = "Mamsen, {Linn Salto} and Karol Charkiewicz and Anderson, {Richard A.} and Telfer, {Evelyn E.} and Marie McLaughlin and Kelsey, {Thomas W.} and Kristensen, {Stine G.} and Gook, {Debra A.} and Erik Ernst and Andersen, {Claus Yding}",
note = "Funding: Novo Nordic Foundation, the International EU project ReproUnion, Sofus Carl Emil og Hustrus Fond, and the Foundation for Polish Science (FNP).",
year = "2019",
month = "6",
doi = "10.1016/j.fertnstert.2019.02.003",
language = "English",
volume = "111",
pages = "1217--1225.e3",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "ELSEVIER SCIENCE INC",
number = "6",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Characterization of follicles in girls and young women with Turner syndrome who underwent ovarian tissue cryopreservation

AU - Mamsen, Linn Salto

AU - Charkiewicz, Karol

AU - Anderson, Richard A.

AU - Telfer, Evelyn E.

AU - McLaughlin, Marie

AU - Kelsey, Thomas W.

AU - Kristensen, Stine G.

AU - Gook, Debra A.

AU - Ernst, Erik

AU - Andersen, Claus Yding

N1 - Funding: Novo Nordic Foundation, the International EU project ReproUnion, Sofus Carl Emil og Hustrus Fond, and the Foundation for Polish Science (FNP).

PY - 2019/6

Y1 - 2019/6

N2 - Objective: To characterize ovarian follicles of girls and young women with Turner syndrome (TS) who underwent ovarian tissue cryopreservation (OTC).Design: Retrospective case-control study.Setting: University hospital.Patient(s): Fifteen girls and young women with TS aged 5-22 years at OTC were included, together with 42 control girls and young women aged 1-25 years who underwent OTC because of cancer.Intervention(s): None.Main Outcome Measure(s): Follicle density (follicles/mm(3)), morphology, and health were assessed in ovarian cortex biopsies from TS patients and compared with controls. Hormone concentrations were measured in serum and follicle fluids. Immature cumulus oocyte complexes were obtained and matured in vitro.Result(s): Follicles were found in 60% of the biopsies (9 of 15) from TS ovaries. In 78% of the ovaries (7 of 9) with follicles, the follicle density was within the 95% confidence interval of the control group. There was a high rate of abnormal follicle morphology. Six follicle-specific proteins were expressed similarly in TS and control ovaries. However, apoptosis and zona pellucida protein expression were found to be abnormal in TS. Turner syndrome follicle fluid from small antral follicles had lower concentrations of estrogen and testosterone and higher concentrations of antimullerian hormone than controls. Thirty-one cumulus oocyte complexes were collected from one patient and cultured for 48 hours in vitro, resulting in five metaphase II oocytes (maturation rate 16%, degeneration rate 19%).Conclusion(s): The benefits of OTC may be limited to a highly selected group of TS mosaic patients in whom a sizeable pool of normal follicles is present at OTC. (C) 2019 by American Society for Reproductive Medicine.

AB - Objective: To characterize ovarian follicles of girls and young women with Turner syndrome (TS) who underwent ovarian tissue cryopreservation (OTC).Design: Retrospective case-control study.Setting: University hospital.Patient(s): Fifteen girls and young women with TS aged 5-22 years at OTC were included, together with 42 control girls and young women aged 1-25 years who underwent OTC because of cancer.Intervention(s): None.Main Outcome Measure(s): Follicle density (follicles/mm(3)), morphology, and health were assessed in ovarian cortex biopsies from TS patients and compared with controls. Hormone concentrations were measured in serum and follicle fluids. Immature cumulus oocyte complexes were obtained and matured in vitro.Result(s): Follicles were found in 60% of the biopsies (9 of 15) from TS ovaries. In 78% of the ovaries (7 of 9) with follicles, the follicle density was within the 95% confidence interval of the control group. There was a high rate of abnormal follicle morphology. Six follicle-specific proteins were expressed similarly in TS and control ovaries. However, apoptosis and zona pellucida protein expression were found to be abnormal in TS. Turner syndrome follicle fluid from small antral follicles had lower concentrations of estrogen and testosterone and higher concentrations of antimullerian hormone than controls. Thirty-one cumulus oocyte complexes were collected from one patient and cultured for 48 hours in vitro, resulting in five metaphase II oocytes (maturation rate 16%, degeneration rate 19%).Conclusion(s): The benefits of OTC may be limited to a highly selected group of TS mosaic patients in whom a sizeable pool of normal follicles is present at OTC. (C) 2019 by American Society for Reproductive Medicine.

KW - Turner syndrome

KW - Follicle density

KW - Ovarian tissue cryopreservation

U2 - 10.1016/j.fertnstert.2019.02.003

DO - 10.1016/j.fertnstert.2019.02.003

M3 - Article

VL - 111

SP - 1217-1225.e3

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 6

ER -

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