Skip to content

Research at St Andrews

Chronic exposure to imidacloprid increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Abstract

The global decline in the abundance and diversity of insect pollinators could result from habitat loss, disease, and pesticide exposure. The contribution
of the neonicotinoid insecticides (e.g., clothianidin and imidacloprid) to this decline is controversial, and key to understanding their risk is whether the astonishingly low levels found in the nectar and pollen of plants is sufficient
to deliver neuroactive levels to their site of action: the bee brain. Here we show that bumblebees (Bombusterrestris audax) fed field levels [10 nM, 2.1 ppb (w/w)] of neonicotinoid accumulate between 4 and 10 nM in their brains within
3 days. Acute (minutes) exposure of cultured neurons to 10 nM clothianidin, but not imidacloprid, causes a nicotinic acetylcholine receptor-dependent rapid mitochondrial depolarization. However, a chronic (2 days) exposure to 1 nM imidacloprid leads to a receptor-dependent increased sensitivity to a normally innocuous level of acetylcholine, which now also causes rapid mitochondrial
depolarization in neurons. Finally, colonies exposed to this level of imidacloprid show deficits in colony growth and nest condition compared with untreated colonies. These findings provide a mechanistic explanation for the poor
navigation and foraging observed in neonicotinoid treated bumblebee colonies.

Close

Details

Original languageEnglish
Pages (from-to)2112-2119
Number of pages8
JournalFASEB Journal
Volume29
Issue number5
Early online date29 Jan 2015
DOIs
Publication statusPublished - May 2015

    Research areas

  • Nicotinic acetylcholine receptors, Neuronal culture

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Assessing factors associated with changes in the numbers of birds visiting gardens in winter: are predators partly to blame?

    Swallow, B. T., Buckland, S. T., King, R. & Toms, M. P., 11 Oct 2019, In : Ecology and Evolution. Early View, 11 p.

    Research output: Contribution to journalArticle

  2. Review of potential line-transect methodologies for estimating abundance of dolphin stocks in the eastern tropical Pacific

    Lennert-Cody, C. E., Buckland, S. T., Gerrodette, T., Webb, A., Barlow, J., Fretwell, P. T., Maunder, M. N., Kitakado, T., Moore, J. E., Scott, M. D. & Skaug, H. J., 25 Jan 2019, In : Journal of Cetacean Research and Management. 19, p. 9-21 13 p.

    Research output: Contribution to journalReview article

  3. Model selection with overdispersed distance sampling data

    Howe, E. J., Buckland, S. T., Després-Einspenner, M-L. & Kühl, H. S., Jan 2019, In : Methods in Ecology and Evolution. 10, 1, p. 38-47

    Research output: Contribution to journalArticle

  4. Distance sampling

    Buckland, S. T., Miller, D. L. & Rexstad, E., 2019, Quantitative Analyses in Wildlife Science. Brennan, L., Marcot, B. & Tri, A. (eds.). Johns Hopkins University Press, p. 97-112

    Research output: Chapter in Book/Report/Conference proceedingChapter

  5. Corrigendum: The number and distribution of polar bears in the western Barents Sea

    Aars, J., Marques, T. A., Lone, K., Andersen, M., Wiig, Ø., Fløystad, I. M. B., Hagen, S. B. & Buckland, S. T., 22 May 2018, In : Polar Research. 37, 1, 1457880.

    Research output: Contribution to journalComment/debate

Related by journal

  1. A novel mutation in SPART gene causes a severe neurodevelopmental delay due to mitochondrial dysfunction with Complex I impairments and altered pyruvate metabolism

    Diquigiovanni, C., Bergamini, C., Diaz, R., Liparulo, I., Bianco, F., Masin, L., Baldassarro, V. A., Rizzardi, N., Tranchina, A., Bruscherini, F., Wischmeijer, A., Pippucci, T., Scarano, E., Cordelli, D. M., Fato, R., Seri, M., Paracchini, S. & Bonora, E., 17 Jul 2019, In : FASEB Journal. Early Online, 19 p.

    Research output: Contribution to journalArticle

  2. PLA2 and ENPP6 may act in concert to generate phosphocholine from the matrix vesicle membrane during skeletal mineralization

    Stewart, A. J., Leong, D. T. K. & Farquharson, C., Jan 2018, In : FASEB Journal. 32, 1, p. 20-25 6 p.

    Research output: Contribution to journalArticle

  3. Structure and mechanism of the CRISPR associated complex for antiviral defense (CASCADE)

    Lawrence, C. M., Lintner, N. G., Kerou, M. & White, M. F., Apr 2012, In : FASEB Journal. 26, 1 p.

    Research output: Contribution to journalAbstract

  4. D-Aspartic acid is a novel endogenous neurotransmitter

    D'Aniello, S., Somorjai, I. M. L., Garcia-Fernandez, J., Topo, E. & D'Aniello, A., Mar 2011, In : FASEB Journal. 25, 3, p. 1014-1027 14 p.

    Research output: Contribution to journalArticle

ID: 202250183

Top