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Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury

Research output: Contribution to journalArticlepeer-review

DOI

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Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury. / Zhao, Rongrong; Andrews, Melissa Renee; Wang, Difei; Warren, Philippa; Gullo, Miriam; Schnell, Lisa; Schwab, Martin E; Fawcett, James W.

In: European Journal of Neuroscience, Vol. 38, No. 6, 09.2013, p. 2946-2961.

Research output: Contribution to journalArticlepeer-review

Harvard

Zhao, R, Andrews, MR, Wang, D, Warren, P, Gullo, M, Schnell, L, Schwab, ME & Fawcett, JW 2013, 'Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury', European Journal of Neuroscience, vol. 38, no. 6, pp. 2946-2961. https://doi.org/10.1111/ejn.12276

APA

Zhao, R., Andrews, M. R., Wang, D., Warren, P., Gullo, M., Schnell, L., Schwab, M. E., & Fawcett, J. W. (2013). Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury. European Journal of Neuroscience, 38(6), 2946-2961. https://doi.org/10.1111/ejn.12276

Vancouver

Zhao R, Andrews MR, Wang D, Warren P, Gullo M, Schnell L et al. Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury. European Journal of Neuroscience. 2013 Sep;38(6):2946-2961. https://doi.org/10.1111/ejn.12276

Author

Zhao, Rongrong ; Andrews, Melissa Renee ; Wang, Difei ; Warren, Philippa ; Gullo, Miriam ; Schnell, Lisa ; Schwab, Martin E ; Fawcett, James W. / Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury. In: European Journal of Neuroscience. 2013 ; Vol. 38, No. 6. pp. 2946-2961.

Bibtex - Download

@article{1ccd12f3e1924c3a8947270811ae926d,
title = "Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury",
abstract = "Anti-Nogo-A antibody and chondroitinase ABC (ChABC) enzyme are two promising treatments that promote functional recovery after spinal cord injury (SCI). Treatment with them has encouraged axon regeneration, sprouting and functional recovery in a variety of spinal cord and central nervous system injury models. The two compounds work, in part, through different mechanisms, so it is possible that their effects will be additive. In this study, we used a rat cervical partial SCI model to explore the effectiveness of a combination of anti-Nogo-A, ChABC, and rehabilitation. We found that spontaneous recovery of forelimb functions reflects the extent of the lesion on the ipsilateral side. We applied a combination treatment with acutely applied anti-Nogo-A antibody followed by delayed ChABC treatment starting at 3 weeks after injury, and rehabilitation starting at 4 weeks, to accommodate the requirement that anti-Nogo-A be applied acutely, and that rehabilitation be given after the cessation of anti-Nogo-A treatment. We found that single treatment with either anti-Nogo-A or ChABC, combined with rehabilitation, produced functional recovery of similar magnitude. The combination treatment, however, was more effective. Both single treatments produced increases in sprouting and axon regeneration, but the combination treatment produced greater increases. Anti-Nogo-A stimulated growth of a greater number of axons with a diameter of > 3 μm, whereas ChABC treatment stimulated increased growth of finer axons with varicosities. These results point to different functions of Nogo-A and chondroitin sulfate proteoglycans in axonal regeneration. The combination of anti-Nogo-A, ChABC and rehabilitation shows promise for enhancing functional recovery after SCI.",
author = "Rongrong Zhao and Andrews, {Melissa Renee} and Difei Wang and Philippa Warren and Miriam Gullo and Lisa Schnell and Schwab, {Martin E} and Fawcett, {James W}",
year = "2013",
month = sep,
doi = "10.1111/ejn.12276",
language = "English",
volume = "38",
pages = "2946--2961",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley",
number = "6",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury

AU - Zhao, Rongrong

AU - Andrews, Melissa Renee

AU - Wang, Difei

AU - Warren, Philippa

AU - Gullo, Miriam

AU - Schnell, Lisa

AU - Schwab, Martin E

AU - Fawcett, James W

PY - 2013/9

Y1 - 2013/9

N2 - Anti-Nogo-A antibody and chondroitinase ABC (ChABC) enzyme are two promising treatments that promote functional recovery after spinal cord injury (SCI). Treatment with them has encouraged axon regeneration, sprouting and functional recovery in a variety of spinal cord and central nervous system injury models. The two compounds work, in part, through different mechanisms, so it is possible that their effects will be additive. In this study, we used a rat cervical partial SCI model to explore the effectiveness of a combination of anti-Nogo-A, ChABC, and rehabilitation. We found that spontaneous recovery of forelimb functions reflects the extent of the lesion on the ipsilateral side. We applied a combination treatment with acutely applied anti-Nogo-A antibody followed by delayed ChABC treatment starting at 3 weeks after injury, and rehabilitation starting at 4 weeks, to accommodate the requirement that anti-Nogo-A be applied acutely, and that rehabilitation be given after the cessation of anti-Nogo-A treatment. We found that single treatment with either anti-Nogo-A or ChABC, combined with rehabilitation, produced functional recovery of similar magnitude. The combination treatment, however, was more effective. Both single treatments produced increases in sprouting and axon regeneration, but the combination treatment produced greater increases. Anti-Nogo-A stimulated growth of a greater number of axons with a diameter of > 3 μm, whereas ChABC treatment stimulated increased growth of finer axons with varicosities. These results point to different functions of Nogo-A and chondroitin sulfate proteoglycans in axonal regeneration. The combination of anti-Nogo-A, ChABC and rehabilitation shows promise for enhancing functional recovery after SCI.

AB - Anti-Nogo-A antibody and chondroitinase ABC (ChABC) enzyme are two promising treatments that promote functional recovery after spinal cord injury (SCI). Treatment with them has encouraged axon regeneration, sprouting and functional recovery in a variety of spinal cord and central nervous system injury models. The two compounds work, in part, through different mechanisms, so it is possible that their effects will be additive. In this study, we used a rat cervical partial SCI model to explore the effectiveness of a combination of anti-Nogo-A, ChABC, and rehabilitation. We found that spontaneous recovery of forelimb functions reflects the extent of the lesion on the ipsilateral side. We applied a combination treatment with acutely applied anti-Nogo-A antibody followed by delayed ChABC treatment starting at 3 weeks after injury, and rehabilitation starting at 4 weeks, to accommodate the requirement that anti-Nogo-A be applied acutely, and that rehabilitation be given after the cessation of anti-Nogo-A treatment. We found that single treatment with either anti-Nogo-A or ChABC, combined with rehabilitation, produced functional recovery of similar magnitude. The combination treatment, however, was more effective. Both single treatments produced increases in sprouting and axon regeneration, but the combination treatment produced greater increases. Anti-Nogo-A stimulated growth of a greater number of axons with a diameter of > 3 μm, whereas ChABC treatment stimulated increased growth of finer axons with varicosities. These results point to different functions of Nogo-A and chondroitin sulfate proteoglycans in axonal regeneration. The combination of anti-Nogo-A, ChABC and rehabilitation shows promise for enhancing functional recovery after SCI.

U2 - 10.1111/ejn.12276

DO - 10.1111/ejn.12276

M3 - Article

VL - 38

SP - 2946

EP - 2961

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 6

ER -

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